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  Chromosome 10

Genes Linked with Cancer (88)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 10; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
ITGB1 10p11.2 CD29, FNRB, MDF2, VLAB, GPIIA, MSK12, VLA-BETA-Breast Cancer
-Prostate Cancer
-Thyroid Cancer
ZEB1 10p11.2 BZP, TCF8, AREB6, FECD6, NIL2A, PPCD3, ZFHEP, ZFHX1A, DELTAEF1-Breast Cancer
-Colorectal Cancer
-Lung Cancer
ABI1 10p11.2 E3B1, ABI-1, ABLBP4, NAP1BP, SSH3BP, SSH3BP1Somatic
Translocation
-Leukaemia
KIF5B 10p11.22 KNS, KINH, KNS1, UKHC, HEL-S-61Somatic-Lung Cancer
-Lung Cancer, Non-Small Cell
MAP3K8 10p11.23 COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Melanoma
BMI1 10p11.23 PCGF4, RNF51, FLVI2/BMI1-Bladder Cancer
-Skin Cancer
-Stomach Cancer
NRP1 10p12 NP1, NRP, BDCA4, CD304, VEGF165R-Brain Stem Glioma, Childhood
-Lung Cancer
-Prostate Cancer
MLLT10 10p12 AF10Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
PTER 10p12 HPHRP, RPR-1-Acute Lymphocytic Leukaemia (ALL)
-Neuroblastoma
-Ovarian Cancer
-Prostate Cancer
-Skin Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
-Testicular Cancer
-Vulvar Cancer
PRINS 10p12.1 NCRNA00074-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
VIM 10p13 HEL113, CTRCT30-Breast Cancer
-Colorectal Cancer
-Kidney Cancer
-Liver Cancer
OLAH 10p13 SAST, AURA1, THEDC1-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Ovarian Cancer
-Skin Cancer
-Thyroid Cancer
STAM 10p14-p13 STAM1, STAM-1-Acute Lymphocytic Leukaemia (ALL)
-Leukaemia
KLF6 10p15 GBF, ZF9, BCD1, CBA1, CPBP, PAC1, ST12, COPEBSomatic-Liver Cancer
-Prostate Cancer
-Stomach Cancer
-Uterine Sarcoma
AKR1C1 10p15-p14 C9, DD1, DDH, DDH1, H-37, HBAB, MBAB, HAKRC, DD1/DD2, 2-ALPHA-HSD, 20-ALPHA-HSD-Breast Cancer
-Lung Cancer
-Non-Hodgkin Lymphoma
-Prostate Cancer
IL2RA 10p15-p14 p55, CD25, IL2R, TCGFR, IDDM10
GATA3 10p15 HDR, HDRSSomatic-Breast Cancer
-Childhood Cancers
AKR1C2 10p15-p14 DD, DD2, TDD, BABP, DD-2, DDH2, HBAB, HAKRD, MCDR2, SRXY8, DD/BABP, AKR1C-pseudo-Breast Cancer
-Esophageal Cancer
-Prostate Cancer
-Stomach Cancer
AKR1C3 10p15-p14 DD3, DDX, PGFS, HAKRB, HAKRe, HA1753, HSD17B5, hluPGFS-Breast Cancer
-Prostate Cancer
-Wilms Tumour
CXCL12 10q11.1 IRH, PBSF, SDF1, TLSF, TPAR1, SCYB12-Breast Cancer
-Cervical Cancer
-Eye Cancer
-Lung Cancer
ALOX5 10q11.2 5-LO, 5LPG, LOG5, 5-LOX-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
MBL2 10q11.2 MBL, MBP, MBP1, MBPD, MBL2D, MBP-C, COLEC1, HSMBPC-Acute Myeloid Leukaemia
-Cervical Cancer
-Haematological Malignancies
-Multiple Myeloma
-Stomach Cancer
NCOA4 10q11.2 RFG, ELE1, PTC3, ARA70Somatic
Fusion
-Prostate Cancer
-Thyroid Cancer
CHAT 10q11.2 CMS1A, CMS1A2, CHOACTASE-Breast Cancer
-Cervical Cancer
-Neuroblastoma
MSMB 10q11.2 MSP, PSP, IGBF, MSPB, PN44, PRPS, HPC13, PSP57, PSP94, PSP-94-Prostate Cancer
RBP3 10q11.2 IRBP, RBPI, RP66, D10S64, D10S65, D10S66-Adrenocortical Cancer
-Multiple Endocrine Neoplasia
-Parathyroid Cancer
-Pheochromocytoma and Paraganglioma
-Thyroid Cancer
DKK1 10q11.2 SK, DKK-1-Bone Cancer (primary)
-Colorectal Cancer
-Lung Cancer
-Multiple Myeloma
RET 10q11.2 PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, CDHF12, CDHR16, RET-ELE1Germline & Somatic
Fusion
-Adrenocortical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Multiple Endocrine Neoplasia Type 2a
-Multiple Endocrine Neoplasia Type 2b
-Pheochromocytoma and Paraganglioma
-Thyroid Cancer
MAPK8 10q11.22 JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2-Breast Cancer
-Lung Cancer
ANXA8 10q11.22 ANX8-Breast Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
ERCC6 10q11.23 CSB, CKN2, COFS, ARMD5, COFS1, RAD26, UVSS1-Bladder Cancer
-Colorectal Cancer
-Lung Cancer
-Skin Cancer
-von Hippel-Lindau Disease
TET1 10q21 LCX, CXXC6, bA119F7.1Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Leukaemia
CCDC6 10q21 H4, PTC, TPC, TST1, D10S170Somatic
Fusion
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Thyroid Cancer
CDK1 10q21.1 CDC2, CDC28A, P34CDC2-Bladder Cancer
-Breast Cancer
-Lung Cancer
EGR2 10q21.1 AT591, CMT1D, CMT4E, KROX20-Ewing's Sarcoma
-Kidney Cancer
-Prostate Cancer
-Stomach Cancer
-Uterine Sarcoma
-Wilms Tumour
CISD1 10q21.1 ZCD1, MDS029, C10orf70, mitoNEET
ARID5B 10q21.2 MRF2, DESRT, MRF-2Germline-Acute Lymphocytic Leukemia (ALL), child
-Endometrial Cancer
SIRT1 10q21.3 SIR2L1-Breast Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
PRF1 10q22 P1, PFP, FLH2, PFN1, HPLH2Germline-Childhood Cancers
DDIT4 10q22.1 Dig2, REDD1, REDD-1-Breast Cancer
-Leukaemia
-Liver Cancer
-Prostate Cancer
NODAL 10q22.1 HTX5-Breast Cancer
-Lung Cancer
-Skin Cancer
-Thyroid Cancer
ANXA7 10q22.2 SNX, ANX7, SYNEXIN-Brain Tumours, Childhood
-Liver Cancer
-Prostate Cancer
-Stomach Cancer
KAT6B 10q22.2 qkf, MORF, MOZ2, GTPTS, MYST4, ZC2HC6B, querkopfSomatic-Breast Cancer
-Prostate Cancer
-Uterine Sarcoma
PLAU 10q22.2 ATF, QPD, UPA, URK, u-PA, BDPLT5-Breast Cancer
-Lung Cancer
-Prostate Cancer
NUTM2B 10q22.3 FAM22B, bA119F19.1Somatic
BMPR1A 10q22.3 ALK3, SKR5, CD292, ACVRLK3, 10q23delGermline-Adenomatous Polyposis Coli
-Childhood Cancers
-Colorectal Cancer
-Prostate Cancer
PLCE1 10q23 PLCE, PPLC, NPHS3-Colorectal Cancer
-Esophageal Cancer
POLL 10q23 BETAN, POLKAPPA-Breast Cancer
-Cervical Cancer
-Ovarian Cancer
-Rectal Cancer
NUTM2A 10q23.2 FAM22ASomatic
BLNK 10q23.2-q23.33 bca, AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
LIPA 10q23.2-q23.3 LAL, CESD-Breast Cancer
-Cervical Cancer
-Liver Cancer
SNCG 10q23.2-q23.3 SR, BCSG1-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
ACTA2 10q23.3 AAT6, ACTSA, MYMY5-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
-Salivary Gland Cancer
PTEN 10q23.3 BZS, DEC, CWS1, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10q23delGermline & Somatic
Amplification
-Astrocytoma, Childhood
-Brain and CNS Tumours
-Breast Cancer
-Endometrial Cancer
-Ewing's Sarcoma
-Lung Cancer
-Mesothelioma
-Prostate Cancer
-Salivary Gland Cancer
-Skin Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
-Testicular Cancer
-Thyroid Cancer
CYP2C8 10q23.33 CPC8, CYPIIC8, MP-12/MP-20-Breast Cancer
-Multiple Myeloma
-Ovarian Cancer
-Stomach Cancer
HHEX 10q23.33 HEX, PRH, HMPH, PRHX, HOX11L-PEN-Acute Myeloid Leukaemia
-Thyroid Cancer
CHUK 10q24-q25 IKK1, IKKA, IKBKA, TCF16, NFKBIKA, IKK-alpha-Breast Cancer
-Melanoma
-Prostate Cancer
-Skin Cancer
ABCC2 10q24 DJS, MRP2, cMRP, ABC30, CMOAT-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Ovarian Cancer
PAX2 10q24 FSGS7, PAPRS-Fallopian tube cancer
-Kidney Cancer
NFKB2 10q24 p52, p100, H2TF1, LYT10, CVID10, LYT-10, NF-kB2Somatic-Breast Cancer
-Multiple Myeloma
-Prostate Cancer
-Skin Cancer
CYP2C9 10q24 CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9-Breast Cancer
-Colorectal Cancer
-Lung Cancer
CYP2C19 10q24 CPCJ, CYP2C, P450C2C, CYPIIC17, CYPIIC19, P450IIC19-Breast Cancer
-Lung Cancer
-Prostate Cancer
FGF8 10q24 HH6, AIGF, KAL6, FGF-8, HBGF-8-Breast Cancer
-Prostate Cancer
LGI1 10q24 EPT, ETL1, ADLTE, ADPAEF, ADPEAF, IB1099, EPITEMPIN-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Neuroblastoma
MXI1 10q24-q25 MXI, MAD2, MXD2, bHLHc11-Melanoma
-Prostate Cancer
-Skin Cancer
-Vulvar Cancer
TLX1 10q24 TCL3, HOX11Somatic-Acute Lymphocytic Leukaemia (ALL)
-Childhood Cancers
-Leukaemia
PDCD4 10q24 H731-Breast Cancer
-Liver Cancer
-Ovarian Cancer
-Uterine Sarcoma
FRAT1 10q24.1 -Lung Cancer
-Ovarian Cancer
FRAT2 10q24.1 -Stomach Cancer
SFRP5 10q24.1 SARP3-Acute Myeloid Leukaemia
-Colorectal Cancer
-Liver Cancer
-Ovarian Cancer
-Stomach Cancer
MGEA5 10q24.1-q24.3 OGA, MEA5, NCOAT-Bladder Cancer
-Soft Tissue Sarcoma
FAS 10q24.1 APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6Somatic-Acute Lymphocytic Leukaemia (ALL)
-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Melanoma
-Multiple Myeloma
-Rectal Cancer
-Skin Cancer
-Stomach Cancer
-Testicular Cancer
-Thyroid Cancer
-Urinary System Cancers
-Apoptosis
CYP17A1 10q24.3 CPT7, CYP17, S17AH, P450C17-Breast Cancer
-Prostate Cancer
-Uterine Sarcoma
SUFU 10q24.32 SUFUH, SUFUXL, PRO1280Germline & Somatic-Brain Tumours, Childhood
-Medulloblastoma
-Childhood Cancers
-Basal Cell Carcinoma (BCC) - Skin
-Stomach Cancer
CASP7 10q25 MCH3, CMH-1, LICE2, CASP-7, ICE-LAP3-Breast Cancer
-Cervical Cancer
-Thyroid Cancer
-Uterine Sarcoma
BAG3 10q25.2-q26.2 BIS, MFM6, BAG-3, CAIR-1-Ovarian Cancer
-Prostate Cancer
-Thyroid Cancer
VTI1A 10q25.2 MMDS3, MVti1, VTI1RP2, Vti1-rp2Somatic-Colorectal Cancer
TCF7L2 10q25.3 TCF4, TCF-4Somatic-Breast Cancer
-Colorectal Cancer
-Liver Cancer
MGMT 10q26 -Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Cervical Cancer
-Childhood Cancers
-Vulvar Cancer
ADAM12 10q26 MCMP, MLTN, CAR10, MLTNA, MCMPMltna, ADAM12-OT1-Breast Cancer
FGFR2 10q26 BEK, JWS, BBDS, CEK3, CFD1, ECT1, KGFR, TK14, TK25, BFR-1, CD332, K-SAMSomatic-Bladder Cancer
-Breast Cancer
-Stomach Cancer
BUB3 10q26 BUB3L, hBUB3-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Stomach Cancer
GFRA1 10q26.11 GDNFR, RET1L, RETL1, TRNR1, GDNFRA, GFR-ALPHA-1-Astrocytoma, Childhood
-Brain Tumours, Childhood
-Lung Cancer
-Skin Cancer
-Thyroid Cancer
DMBT1 10q26.13 GP340, muclin-Brain and CNS Tumours
-Breast Cancer
-Esophageal Cancer
-Lung Cancer
-Skin Cancer
-Stomach Cancer
MKI67 10q26.2 KIA, MIB-1-Breast Cancer
-Lung Cancer
-Prostate Cancer
CYP2E1 10q26.3 CPE1, CYP2E, P450-J, P450C2E-Lung Cancer
-Stomach Cancer
-Urinary System Cancers
HTRA1 10q26.3 L56, HtrA, ARMD7, ORF480, PRSS11, CARASIL-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Endometrial Cancer
-Ovarian Cancer
BNIP3 10q26.3 NIP3-Breast Cancer
-Colorectal Cancer
-Pancreatic Cancer
-Prostate Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 10:

Abnormality Type Gene(s)
KIF5B-ALK Rearrangements in Lung CancerKIF5B (10p11.22)
RET-KIF5B fusion in Adenocarcinoma Lung CancerKIF5B (10p11.22)RET (10q11.2)
RET-NTRK1 Rearangements in Papillary Thyroid CancerFusionRET (10q11.2)NTRK1 (1q21-q22)
RET-PTC1 Rearangements in Papillary Thyroid CancerFusionRET (10q11.2)CCDC6 (10q21)
RET-PTC3 (RET-ELE1) Rearangements in Papillary Thyroid CancerFusionRET (10q11.2)NCOA4 (10q11.2)
t(8,10) RET-HOOK Reaarangements in Papillary Thyroid CancerTranslocationRET (10q11.2)HOOK3 (8p11.21)
t(10;11)(p12;q23) AF10-MLL translocation in Acute LeukaemiaTranslocationMLLT10 (10p12)KMT2A (11q23)
t(10;11)(p13;q14) AF10-PICALM translocation in Acute LeukaemiaTranslocationMLLT10 (10p12)PICALM (11q14)
t(10;11)(p11.2;q23) ABI1-MLL translocation in LeukemiaTranslocationABI1 (10p11.2)KMT2A (11q23)
t(10;11) MLL-TET1 rearrangement in acute leukemiasTranslocationTET1 (10q21)KMT2A (11q23)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

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Cite this page: Cotterill SJ. Chromosome 10, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc10.htm Accessed: date

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