Chromosome 10 | Cancer Genetics Web

Genes Linked with Cancer (95)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 10; or Sort by clicking on a column heading e.g. 'Gene'.

Gene	Location	Aliases	Abnormalities	Implicated in
NRP1	10p11.22	NP1, NRP, BDCA4, CD304, VEGF165R		-Brain Stem Glioma, Childhood -Breast Cancer -Lung Cancer -Prostate Cancer -Stomach Cancer
ITGB1	10p11.22	CD29, FNRB, MDF2, VLAB, GPIIA, MSK12, VLA-BETA		-Breast Cancer -Prostate Cancer -Thyroid Cancer
ZEB1	10p11.22	BZP, TCF8, AREB6, FECD6, NIL2A, PPCD3, ZFHEP, ZFHX1A, DELTAEF1		-Breast Cancer -Colorectal Cancer -Lung Cancer -Pancreatic Cancer
KIF5B	10p11.22	KNS, KINH, KNS1, UKHC, HEL-S-61	Somatic	-Lung Cancer -Lung Cancer, Non-Small Cell
MAP3K8	10p11.23	COT, EST, ESTF, TPL2, AURA2, MEKK8, Tpl-2, c-COT		-Breast Cancer -Colorectal Cancer -Lung Cancer -Melanoma -Multiple Myeloma -Ovarian Cancer -Thyroid Cancer
PRINS	10p12.1	NCRNA00074		-Brain Stem Glioma, Childhood -Brain Tumours, Childhood -Breast Cancer -Colorectal Cancer -Esophageal Cancer -Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
ABI1	10p12.1	E3B1, ABI-1, ABLBP4, NAP1BP, SSH3BP, SSH3BP1	Somatic Translocation	-Leukaemia
BMI1	10p12.2	PCGF4, RNF51, FLVI2/BMI1, flvi-2/bmi-1		-Bladder Cancer -Prostate Cancer -Skin Cancer -Stomach Cancer
MLLT10	10p12.31	AF10	Somatic Translocation	-Acute Lymphocytic Leukaemia (ALL)
STAM	10p12.33	STAM1, STAM-1		-Acute Lymphocytic Leukaemia (ALL) -Leukaemia
PTER	10p13	HPHRP, RPR-1		-Acute Lymphocytic Leukaemia (ALL) -Ewing's Sarcoma -Neuroblastoma -Ovarian Cancer -Prostate Cancer -Skin Cancer -Soft Tissue Sarcoma -Stomach Cancer -Testicular Cancer -Vulvar Cancer
VIM	10p13	HEL113, CTRCT30		-Breast Cancer -Colorectal Cancer -Kidney Cancer -Liver Cancer -von Hippel-Lindau Disease
OLAH	10p13	SAST, AURA1, THEDC1		-Acute Lymphocytic Leukaemia (ALL) -Breast Cancer -Ovarian Cancer -Skin Cancer -Thyroid Cancer
GATA3	10p14	HDR, HDRS	Somatic	-Breast Cancer -Lung Cancer
AKR1C3	10p15.1	DD3, DDX, PGFS, HAKRB, HAKRe, HA1753, HSD17B5, hluPGFS		-Breast Cancer -Prostate Cancer -Wilms Tumour
AKR1C1	10p15.1	C9, DD1, DDH, DDH1, H-37, HBAB, MBAB, HAKRC, DD1/DD2, 2-ALPHA-HSD, 20-ALPHA-HSD		-Breast Cancer -Lung Cancer -Non-Hodgkin Lymphoma -Prostate Cancer
AKR1C2	10p15.1	DD, DD2, TDD, BABP, DD-2, DDH2, HBAB, HAKRD, MCDR2, SRXY8, DD/BABP, AKR1C-pseudo		-Breast Cancer -Esophageal Cancer -Liver Cancer -Prostate Cancer -Stomach Cancer
IL2RA	10p15.1	p55, CD25, IL2R, IMD41, TCGFR, IDDM10		-Acute Myeloid Leukaemia -Breast Cancer
KLF6	10p15.2	GBF, ZF9, BCD1, CBA1, CPBP, PAC1, ST12, COPEB	Somatic	-Brain Tumours, Childhood -Ewing's Sarcoma -Liver Cancer -Prostate Cancer -Stomach Cancer -Uterine Sarcoma
ALOX5	10q11.21	5-LO, 5LPG, LOG5, 5-LOX		-Bladder Cancer -Breast Cancer -Colorectal Cancer -Lung Cancer -Prostate Cancer
CXCL12	10q11.21	IRH, PBSF, SDF1, TLSF, TPAR1, SCYB12		-Breast Cancer -Cervical Cancer -Eye Cancer -Lung Cancer -Small Cell Lung Cancer -Ovarian Cancer
RET	10q11.21	PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, CDHF12, CDHR16, RET-ELE1	Germline & Somatic Fusion	-Adrenocortical Cancer -Lung Cancer -Lung Cancer, Non-Small Cell -Multiple Endocrine Neoplasia Type 2a -Multiple Endocrine Neoplasia Type 2b -Pheochromocytoma and Paraganglioma -Thyroid Cancer
MSMB	10q11.22	MSP, PSP, IGBF, MSPB, PN44, PRPS, HPC13, PSP57, PSP94, PSP-94		-Prostate Cancer
ANXA8	10q11.22	ANX8, CH17-360D5.2		-Breast Cancer -Cervical Cancer -Liver Cancer -Lung Cancer -Oral Cavity Cancer -Pancreatic Cancer
MAPK8	10q11.22	JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2		-Breast Cancer -Lung Cancer
NCOA4	10q11.22	RFG, ELE1, PTC3, ARA70	Somatic Fusion	-Prostate Cancer -Thyroid Cancer
RBP3	10q11.22	IRBP, RBPI, RP66, D10S64, D10S65, D10S66		-Adrenocortical Cancer -Multiple Endocrine Neoplasia -Parathyroid Cancer -Pheochromocytoma and Paraganglioma -Thyroid Cancer
CHAT	10q11.23	CMS6, CMS1A, CMS1A2, CHOACTASE		-Acute Myeloid Leukaemia -Breast Cancer -Cervical Cancer -Down Syndrome -Leukaemia -Lung Cancer -Small Cell Lung Cancer -Neuroblastoma -Retinoblastoma
ERCC6	10q11.23	CSB, CKN2, COFS, ARMD5, COFS1, POF11, RAD26, UVSS1		-Bladder Cancer -Breast Cancer -Colorectal Cancer -Lung Cancer -Skin Cancer -von Hippel-Lindau Disease
MBL2	10q21.1	MBL, MBP, MBP1, MBPD, MBL2D, MBP-C, COLEC1, HSMBPC		-Acute Myeloid Leukaemia -Cervical Cancer -Haematological Malignancies -Liver Cancer -Multiple Myeloma -Stomach Cancer
CISD1	10q21.1	ZCD1, MDS029, C10orf70, mitoNEET
DKK1	10q21.1	SK, DKK-1		-Bone Cancer (primary) -Colorectal Cancer -Liver Cancer -Lung Cancer -Multiple Myeloma -Stomach Cancer
CCDC6	10q21.2	H4, PTC, TPC, TST1, D10S170	Somatic Fusion	-Lung Cancer -Lung Cancer, Non-Small Cell -Thyroid Cancer
ARID5B	10q21.2	MRF2, DESRT, MRF-2	Germline	-Acute Lymphocytic Leukemia (ALL), child -Endometrial Cancer
CDK1	10q21.2	CDC2, CDC28A, P34CDC2		-Bladder Cancer -Breast Cancer -Lung Cancer
EGR2	10q21.3	AT591, CMT1D, CMT4E, KROX20		-Ewing's Sarcoma -Kidney Cancer -Prostate Cancer -Stomach Cancer -Uterine Sarcoma -Wilms Tumour
SIRT1	10q21.3	SIR2, SIR2L1, SIR2alpha		-Breast Cancer -Liver Cancer -Lung Cancer -Pancreatic Cancer -Prostate Cancer -Stomach Cancer
TET1	10q21.3	LCX, CXXC6, bA119F7.1	Somatic Translocation	-Acute Lymphocytic Leukaemia (ALL) -Leukaemia
PRF1	10q22.1	P1, PFP, FLH2, PFN1, HPLH2	Germline	-Acute Lymphocytic Leukaemia (ALL) -Haematological Malignancies -Hodgkin Lymphoma -Waldenstrom's Macroglobulinemia
NODAL	10q22.1	HTX5		-Breast Cancer -Colorectal Cancer -Lung Cancer -Lung Cancer, Non-Small Cell -Small Cell Lung Cancer -Oral Cavity Cancer -Skin Cancer -Thyroid Cancer -Uterine Sarcoma -Vulvar Cancer
DDIT4	10q22.1	Dig2, REDD1, REDD-1		-Breast Cancer -Leukaemia -Liver Cancer -Prostate Cancer
ANXA7	10q22.2	SNX, ANX7, SYNEXIN		-Brain Tumours, Childhood -Liver Cancer -Prostate Cancer -Stomach Cancer
PLAU	10q22.2	ATF, QPD, UPA, URK, u-PA, BDPLT5		-Breast Cancer -Head and Neck Cancers -Lung Cancer -Pancreatic Cancer -Prostate Cancer -Stomach Cancer
KAT6B	10q22.2	qkf, MORF, MOZ2, GTPTS, MYST4, ZC2HC6B, querkopf	Somatic	-Breast Cancer -Prostate Cancer -Uterine Sarcoma
MAT1A	10q22.3	MAT, SAMS, MATA1, SAMS1		-Liver Cancer
NUTM2B	10q22.3	FAM22B, bA119F19.1	Somatic	-Kidney Cancer
BMPR1A	10q23.2	ALK3, SKR5, CD292, ACVRLK3, 10q23del	Germline	-Adenomatous Polyposis Coli -Colorectal Cancer -Cowden Syndrome -Hereditary Nonpolyposis Colorectal Cancer (HNPCC) -Peutz-Jeghers Syndrome -Prostate Cancer
NUTM2A	10q23.2	FAM22A	Somatic	-Endometrial Cancer
SNCG	10q23.2	SR, BCSG1		-Breast Cancer -Colorectal Cancer -Ovarian Cancer
ACTA2	10q23.31	AAT6, ACTSA, MYMY5		-Breast Cancer -Colorectal Cancer -Lung Cancer -Prostate Cancer -Salivary Gland Cancer
LIPA	10q23.31	LAL, CESD		-Breast Cancer -Cervical Cancer -Liver Cancer -Penile Cancer
KLLN	10q23.31	CWS4, KILLIN		-Breast Cancer -Cowden Syndrome -Endometrial Cancer -Kidney Cancer -Ovarian Cancer -Prostate Cancer -Thyroid Cancer
FAS	10q23.31	APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6	Somatic	-Acute Lymphocytic Leukaemia (ALL) -Bladder Cancer -Breast Cancer -Cervical Cancer -Lung Cancer -Melanoma -Multiple Myeloma -Rectal Cancer -Skin Cancer -Stomach Cancer -Testicular Cancer -Thyroid Cancer -Urinary System Cancers -Apoptosis
MIR107	10q23.31	MIRN107, miR-107		-Brain Stem Glioma, Childhood -Brain Tumours, Childhood -Breast Cancer -Liver Cancer -Lung Cancer -Lung Cancer, Non-Small Cell -Neuroblastoma -Pancreatic Cancer -Prostate Cancer -Stomach Cancer
PTEN	10q23.31	BZS, DEC, CWS1, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10q23del	Germline & Somatic Amplification	-Astrocytoma, Childhood -Brain and CNS Tumours -Breast Cancer -Cowden Syndrome -Endometrial Cancer -Ewing's Sarcoma -Lung Cancer -Mesothelioma -Prostate Cancer -Salivary Gland Cancer -Skin Cancer -Soft Tissue Sarcoma -Stomach Cancer -Testicular Cancer -Thyroid Cancer
PLCE1	10q23.33	PLCE, PPLC, NPHS3		-Colorectal Cancer -Esophageal Cancer
HHEX	10q23.33	HEX, PRH, HMPH, PRHX, HOX11L-PEN		-Acute Myeloid Leukaemia -Thyroid Cancer
CYP2C9	10q23.33	CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9		-Breast Cancer -Colorectal Cancer -Lung Cancer
CYP2C8	10q23.33	CPC8, CYPIIC8, MP-12/MP-20		-Breast Cancer -Multiple Myeloma -Ovarian Cancer -Stomach Cancer
LGI1	10q23.33	EPT, ETL1, ADLTE, ADPAEF, ADPEAF, IB1099, EPITEMPIN		-Brain Stem Glioma, Childhood -Brain Tumours, Childhood -Neuroblastoma
CYP2C19	10q23.33	CPCJ, CYP2C, P450C2C, CYPIIC17, CYPIIC19, P450IIC19		-Breast Cancer -Liver Cancer -Lung Cancer -Prostate Cancer -Stomach Cancer
BLNK	10q24.1	bca, AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65		-Acute Lymphocytic Leukaemia (ALL) -Acute Myeloid Leukaemia
FRAT1	10q24.1			-Lung Cancer -Ovarian Cancer
FRAT2	10q24.1			-Stomach Cancer
ABCC2	10q24.2	DJS, MRP2, cMRP, ABC30, CMOAT		-Acute Lymphocytic Leukaemia (ALL) -Breast Cancer -Colorectal Cancer -Lung Cancer -Ovarian Cancer -Skin Cancer
SFRP5	10q24.2	SARP3		-Acute Myeloid Leukaemia -Breast Cancer -Colorectal Cancer -Liver Cancer -Ovarian Cancer -Stomach Cancer
TLX1	10q24.31	TCL3, HOX11	Somatic	-Acute Lymphocytic Leukaemia (ALL) -Leukaemia
PAX2	10q24.31	FSGS7, PAPRS		-Fallopian tube cancer -Kidney Cancer
CHUK	10q24.31	IKK1, IKKA, IKBKA, TCF16, NFKBIKA, IKK-alpha		-Breast Cancer -Liver Cancer -Lung Cancer -Melanoma -Prostate Cancer -Skin Cancer
MGEA5	10q24.32	OGA, MEA5, NCOAT		-Bladder Cancer -Breast Cancer -Soft Tissue Sarcoma
CYP17A1	10q24.32	CPT7, CYP17, S17AH, P450C17		-Breast Cancer -Prostate Cancer -Uterine Sarcoma
BTRC	10q24.32	FWD1, FBW1A, FBXW1, bTrCP, FBXW1A, bTrCP1, betaTrCP, BETA-TRCP		-Breast Cancer -Liver Cancer -Prostate Cancer
NFKB2	10q24.32	p52, p100, H2TF1, LYT10, CVID10, LYT-10, NF-kB2, p49/p100	Somatic	-Breast Cancer -Lymphoma -Multiple Myeloma -Prostate Cancer -Skin Cancer
POLL	10q24.32	BETAN, POLKAPPA		-Breast Cancer -Cervical Cancer -Colorectal Cancer -Ovarian Cancer -Prostate Cancer -Rectal Cancer
FGF8	10q24.32	HH6, AIGF, KAL6, FGF-8, HBGF-8		-Breast Cancer -Prostate Cancer
SUFU	10q24.32	SUFUH, SUFUXL, PRO1280	Germline & Somatic	-Basal Cell Nevus Syndrome -Brain Tumours, Childhood -Medulloblastoma -Basal Cell Carcinoma (BCC) - Skin -Stomach Cancer
NEURL1	10q24.33	neu, NEUR1, NEURL, RNF67, neu-1, bA416N2.1		-Brain Tumours, Childhood -Esophageal Cancer -Medulloblastoma
GSTO2	10q25.1	GSTO 2-2, bA127L20.1		-Bladder Cancer -Breast Cancer -Liver Cancer -Ovarian Cancer -Skin Cancer -Urinary System Cancers
GSTO1	10q25.1	P28, SPG-R, GSTO 1-1, GSTTLp28, HEL-S-21		-Acute Lymphocytic Leukaemia (ALL) -Bladder Cancer -Breast Cancer -Liver Cancer -Prostate Cancer -Transitional Cell Cancer of the Renal Pelvis and Ureter -Urinary System Cancers
TCF7L2	10q25.2-q25.3	TCF4, TCF-4	Somatic	-Breast Cancer -Colorectal Cancer -Liver Cancer
MXI1	10q25.2	MXI, MAD2, MXD2, bHLHc11		-Melanoma -Prostate Cancer -Skin Cancer -Vulvar Cancer
VTI1A	10q25.2	MMDS3, MVti1, VTI1RP2, Vti1-rp2	Somatic	-Colorectal Cancer -Lung Cancer
PDCD4	10q25.2	H731		-Breast Cancer -Liver Cancer -Ovarian Cancer -Uterine Sarcoma
GFRA1	10q25.3	GDNFR, RET1L, RETL1, TRNR1, GDNFRA, GFR-ALPHA-1		-Astrocytoma, Childhood -Brain Tumours, Childhood -Lung Cancer -Skin Cancer -Thyroid Cancer
CASP7	10q25.3	MCH3, CMH-1, LICE2, CASP-7, ICE-LAP3		-Breast Cancer -Cervical Cancer -Skin Cancer -Thyroid Cancer -Uterine Sarcoma
BAG3	10q26.11	BIS, MFM6, BAG-3, CAIR-1		-Lung Cancer -Ovarian Cancer -Prostate Cancer -Thyroid Cancer
DMBT1	10q26.13	SAG, GP340, SALSA, muclin		-Brain and CNS Tumours -Breast Cancer -Esophageal Cancer -Lung Cancer -Skin Cancer -Stomach Cancer
BUB3	10q26.13	BUB3L, hBUB3		-Bladder Cancer -Brain Tumours, Childhood -Breast Cancer -Stomach Cancer
HTRA1	10q26.13	L56, HtrA, ARMD7, ORF480, PRSS11, CARASIL, CADASIL2		-Bladder Cancer -Breast Cancer -Cervical Cancer -Endometrial Cancer -Lung Cancer -Ovarian Cancer
FGFR2	10q26.13	BEK, JWS, BBDS, CEK3, CFD1, ECT1, KGFR, TK14, TK25, BFR-1, CD332, K-SAM	Somatic	-Bladder Cancer -Breast Cancer -Lung Cancer -Stomach Cancer -Synovial Sarcoma
MKI67	10q26.2	KIA, MIB-, MIB-1, PPP1R105		-Brain Tumours, Childhood -Breast Cancer -Fallopian tube cancer -Lung Cancer -Prostate Cancer -Uterine Sarcoma
ADAM12	10q26.2	MCMP, MLTN, CAR10, MLTNA, MCMPMltna, ADAM12-OT1		-Breast Cancer
MGMT	10q26.3			-Brain and CNS Tumours -Brain Stem Glioma, Childhood -Brain Tumours, Childhood -Cervical Cancer -Colorectal Cancer -Stomach Cancer -Vulvar Cancer
BNIP3	10q26.3	NIP3		-Breast Cancer -Colorectal Cancer -Pancreatic Cancer -Prostate Cancer
CYP2E1	10q26.3	CPE1, CYP2E, P450-J, P450C2E		-Lung Cancer -Stomach Cancer -Urinary System Cancers

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 10:

Abnormality	Type	Gene(s)
KIF5B-ALK Rearrangements in Lung Cancer		KIF5B (10p11.22)
RET-KIF5B fusion in Adenocarcinoma Lung Cancer		KIF5B (10p11.22)	RET (10q11.21)
RET-NTRK1 Rearangements in Papillary Thyroid Cancer	Fusion	RET (10q11.21)	NTRK1 (1q23.1)
RET-PTC1 Rearangements in Papillary Thyroid Cancer	Fusion	RET (10q11.21)	CCDC6 (10q21.2)
RET-PTC3 (RET-ELE1) Rearangements in Papillary Thyroid Cancer	Fusion	RET (10q11.21)	NCOA4 (10q11.22)
t(8,10) RET-HOOK Reaarangements in Papillary Thyroid Cancer	Translocation	RET (10q11.21)	HOOK3 (8p11.21)
t(10;11)(p12;q23) AF10-MLL translocation in Acute Leukaemia	Translocation	MLLT10 (10p12.31)	KMT2A (11q23.3)
t(10;11)(p13;q14) AF10-PICALM translocation in Acute Leukaemia	Translocation	MLLT10 (10p12.31)	PICALM (11q14.2)
t(10;11)(p11.2;q23) ABI1-MLL translocation in Leukemia	Translocation	ABI1 (10p12.1)	KMT2A (11q23.3)
t(10;11) MLL-TET1 rearrangement in acute leukemias	Translocation	TET1 (10q21.3)	KMT2A (11q23.3)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.