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  Chromosome 10

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 10; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
ITGB1 10p11.2 CD29, FNRB, MDF2, VLAB, GPIIA, MSK12, VLA-BETA-Breast Cancer
-Prostate Cancer
-Thyroid Cancer
ABI1 10p11.2 E3B1, ABI-1, ABLBP4, NAP1BP, SSH3BP, SSH3BP1Somatic
Translocation
-Leukaemia
KIF5B 10p11.22 KNS, KINH, KNS1, UKHC, HEL-S-61Somatic-Lung Cancer
-Lung Cancer, Non-Small Cell
MAP3K8 10p11.23 COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT
BMI1 10p11.23 PCGF4, RNF51, FLVI2/BMI1
MLLT10 10p12 AF10Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL) - adult
VIM 10p13 HEL113, CTRCT30
KLF6 10p15 GBF, ZF9, BCD1, CBA1, CPBP, PAC1, ST12, COPEBSomatic
GATA3 10p15 HDR, HDRSSomatic
NCOA4 10q11.2 RFG, ELE1, PTC3, ARA70Somatic
Fusion
-Prostate Cancer
-Thyroid Cancer
MSMB 10q11.2 MSP, PSP, IGBF, MSPB, PN44, PRPS, HPC13, PSP57, PSP94, PSP-94-Prostate Cancer
RET 10q11.2 PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, CDHF12, CDHR16, RET-ELE1Germline & Somatic
Fusion
-Lung Cancer
-Thyroid Cancer
MAPK8 10q11.22 JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2
CCDC6 10q21 H4, PTC, TPC, TST1, D10S170Somatic
Fusion
-Thyroid Cancer
TET1 10q21 LCX, CXXC6, bA119F7.1Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL) - adult
-Leukaemia
CISD1 10q21.1 ZCD1, MDS029, C10orf70, mitoNEET
ARID5B 10q21.2 MRF2, DESRT, MRF-2Germline-Acute Lymphocytic Leukemia (ALL), child
-Endometrial Cancer
PRF1 10q22 P1, PFP, FLH2, PFN1, HPLH2Germline
KAT6B 10q22.2 qkf, MORF, MOZ2, GTPTS, MYST4, ZC2HC6B, querkopfSomatic
PLAU 10q22.2 ATF, QPD, UPA, URK, u-PA, BDPLT5
BMPR1A 10q22.3 ALK3, SKR5, CD292, ACVRLK3, 10q23delGermline
NUTM2B 10q22.3 FAM22B, bA119F19.1Somatic
SNCG 10q23.2-q23.3 SR, BCSG1
NUTM2A 10q23.2 FAM22ASomatic
PTEN 10q23.3 BZS, DEC, CWS1, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10q23delGermline & Somatic
Amplification
-Brain and CNS Tumours
-Brain, Astrocytoma, Childhood
-Endometrial Cancer
-Ewing's Sarcoma
-Lung Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
-Testicular Cancer
-Thyroid Cancer
MXI1 10q24-q25 MXI, MAD2, MXD2, bHLHc11
LGI1 10q24 EPT, ETL1, ADLTE, ADPAEF, ADPEAF, IB1099, EPITEMPIN
FGF8 10q24 HH6, AIGF, KAL6, FGF-8, HBGF-8
NFKB2 10q24 p52, p105, H2TF1, LYT10, CVID10, LYT-10, NF-kB2Somatic
TLX1 10q24 TCL3, HOX11Somatic
PDCD4 10q24 H731
MGEA5 10q24.1-q24.3 OGA, MEA5, NCOAT
FRAT2 10q24.1
FRAT1 10q24.1
FAS 10q24.1 APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6Somatic
CYP17A1 10q24.3 CPT7, CYP17, S17AH, P450C17
SUFU 10q24.32 SUFUH, SUFUXL, PRO1280Germline & Somatic
VTI1A 10q25.2 MMDS3, MVti1, VTI1RP2, Vti1-rp2Somatic
TCF7L2 10q25.3 TCF4, TCF-4Somatic
MGMT 10q26
FGFR2 10q26 BEK, JWS, BBDS, CEK3, CFD1, ECT1, KGFR, TK14, TK25, BFR-1, CD332, K-SAMSomatic
DMBT1 10q26.13 GP340, muclin
MKI67 10q26.2 KIA, MIB-1-Breast Cancer
-Lung Cancer
-Prostate Cancer
CYP2E1 10q26.3 CPE1, CYP2E, P450-J, P450C2E

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 10:

Abnormality Type Gene(s)
KIF5B-ALK Rearrangements in Lung CancerKIF5B (10p11.22)
KIF5B-RET fusion in Adenosarcoma Lung CancerKIF5B (10p11.22)RET (10q11.2)
RET-NTRK1 Rearangements in Papillary Thyroid CancerFusionRET (10q11.2)NTRK1 (1q21-q22)
RET-PTC1 Rearangements in Papillary Thyroid CancerFusionRET (10q11.2)CCDC6 (10q21)
RET-PTC3 (RET-ELE1) Rearangements in Papillary Thyroid CancerFusionRET (10q11.2)NCOA4 (10q11.2)
t(10;11)(p12;q23) AF10-MLL translocation in Acute LeukaemiaTranslocationMLLT10 (10p12)KMT2A (11q23)
t(10;11)(p13;q14) AF10-PICALM translocation in Acute LeukaemiaTranslocationMLLT10 (10p12)PICALM (11q14)
t(10;11)(p11.2;q23) ABI1-MLL translocation in LeukemiaTranslocationABI1 (10p11.2)KMT2A (11q23)
t(10;11) MLL-TET1 rearrangement in acute leukemiasTranslocationTET1 (10q21)KMT2A (11q23)
t(8,10) HOOK-RET Reaarangements in Papillary Thyroid CancerTranslocationRET (10q11.2)HOOK3 (8p11.21)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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