 Summary Information
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Location: 10q26
A p53 related gene involved in DNA repair and drug resistance.
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| Gene Database Entries for MGMT
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OMIM
GeneCard (Weizmann Institute)
Genbank
Swiss-Prot
Locus Link (search for MGMT)
UniGene
GenAtlas
GDB
Nomenclature (search for MGMT)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND MGMT[TI] (PubMed)
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| MGMT Function and Drug Resistance
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Grombacher T, et al. p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents. Oncogene 1998; 17(7):845-51 Related articles (PubMed)
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| MGMT and CNS Tumours
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Nagane M, et al. Expression Pattern of Chemoresistance-related Genes in Human Malignant Brain Tumors: a Working Knowledge for Proper Selection of Anticancer Drugs Japan J Clin Oncol 1999; 29(11): 527-34 Related articles
Kokkinakis DM, et al. Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea. Clin Cancer Res 1999; 5(11):3676-81 Related articles (PubMed)
Rolhion C, et al. O(6)-methylguanine-DNA methyltransferase gene (MGMT) expression in human glioblastomas in relation to patient characteristics and p53 accumulation. Int J Cancer. 1999; 84(4):416-20 Related articles (PubMed)
Silber JR, et al. O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics. Cancer Res. 1998; 58(5):1068-73 Related articles (PubMed)
Medline Search: MGMT and CNS tumors (PubMed)
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 Brain and CNS Tumours : Clinical and Epidemiological Information
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| MGMT and Oral Cancers
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Guo W, et al. High O6-methylguanine methyl transferase activity is frequently found in human oral cancer cells with p53 inactivation. Int J Oncol 1999; 15(4):817-21 Related articles (PubMed)
Medline Search: MGMT and oral cancer (PubMed)
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Oral cavity, Lip, Salivary gland Ca. Genetics
Oral cavity, Lip, Salivary gland Ca.: Clinical and Epidemiological Information
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| MGMT and Ovarian Cancer
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Hengstler JG, et al. Activity of O(6)-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer. Int J Cancer. 1999; 84(4):388-95 Related articles (PubMed)
Chen SS, et al. O6-methylguanine-DNA methyltransferase in ovarian malignancy and its correlation with postoperative response to chemotherapy. Gynecol Oncol. 1994; 52(2):172-4 Related articles (PubMed)
Medline Search: MGMT and ovarian cancer (PubMed)
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Ovarian Ca. Genetics
Ovarian Ca. : Clinical and Epidemiological Information
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| MGMT and Lung Cancer
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Rusin M, et al. Novel genetic polymorphisms in DNA repair genes: O(6)-methylguanine-DNA methyltransferase (MGMT) and N-methylpurine-DNA glycosylase (MPG) in lung cancer patients from Poland. Hum Mutat (Online). 1999 Sep 19;14(3):269-70. Related articles (PubMed)
Mattern J, et al. Smoking-related increase of O6-methylguanine-DNA methyltransferase expression in human lung carcinomas. Carcinogenesis. 1998;19(7):1247-50 Related articles (PubMed)
- Related Resources
Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
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| MGMT and Drug Resistance Gene Therapy
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Davis BM, et al. Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy. Hum Gene Ther 1999; 10(17):2769-78 Related articles (PubMed)
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| MGMT and Hepatocellular Carcinma
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Major GN, Collier JD Repair of DNA lesion O6-methylguanine in hepatocellular carcinogenesis. [Review] J Hepatobiliary Pancreat Surg 1998;5(4):355-66 Related articles (PubMed)
- Related Resources
Hepatocelular Carcinoma Genetics
Hepatocelular Carcinoma : Clinical and Epidemiological Information
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