 Summary Information
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Location: 3p21.3
Aliases: HNPCC2, COCA2
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| Gene Database Entries for MLH1
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OMIM
GeneCard (Weizmann Institute)
Human Gene Mutation Database (Cardiff, UK)
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for MLH1)
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| Other Related Resources
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Colon Cancer and the MLH1 and MSH2 genes (National Center for Biotechnology Information) an overview of colon cancer and the MLH1 / MSH2 genes with links to other gene databases.
Hereditary Non-Polyposis Colorectal Cancer - Mutation Databases (International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer) includes databases of MLH1, MSH2, MSH6, PMS1 and PMS2 mutations.
 Colon Cancer Resources
Colon Cancer Genetics
MSH2 gene (2p22-p21)
Medline Search: MLH1 (PubMed)
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- Medline Search: cancer AND gene AND (MLH1[TI] OR HNPCC2[TI] OR COCA2[TI]) (PubMed)
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| MLH1 and Hereditary NonPolyposis Colorectal Cancer
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Park JG, et al. Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) criteria and results of genetic diagnosis. Dis Colon Rectum. 1999;42(6):710-5 Related articles (PubMed)
Wang Q et al. Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, nonpolyposis colorectal cancer. Hum Genet 1999; 105:79-85 Related articles (PubMed)
Lindblom A, et al. Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer. Nat Genet 1993; 5(3):279-82 Related articles (PubMed)
Liu B, et al. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med 1996; 2(2):169-74 Related articles (PubMed)
Medline Search: hereditary nonpolyposis colorectal cancer AND (mlh1 or hpcc2) (PubMed)
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- Related Resources
ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information
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| MLH1 and Familial Gastric Cancer
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Yanagisawa Y, et al. Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability. Int J Cancer 2000 Jan 1;85(1):50-3 Related articles (PubMed)
Medline Search: familial gastric cancer AND mlh1 (PubMed)
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Stomach (Gastric) Cancer Genetics
Stomach (Gastric) Cancer : Clinical and Epidemiological Information
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[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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