 Summary Information
|
Location: 15q25
Alias: TRKC
 Return to NTRK3 Contents
|
| Gene Database Entries for NTRK3
|
OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Genbank
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for NTRK3)
Return to NTRK3 Contents
|
| Other Related Resources
|
- Search Medline for related articles (PubMed)
-
- Medline Search: cancer AND gene AND (NTRK3[TI] OR TRKC[TI]) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
Return to NTRK3 Contents
|
| NTRK3 and Neuroblastoma
|
Yamashiro DJ, et al. Expression and function of Trk-C in favourable human neuroblastomas. Eur J Cancer. 1997; 33(12):2054-7 Related articles (PubMed)
Medline Search: neuroblastoma AND (trk-c OR trkc OR ntrk3) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
 NTRK1 (trkA)- NTRK2 (trkB)
Neuroblastoma Genetics
Neuroblastoma : Clinical and Epidemiological Information
Return to NTRK3 Contents
|
| NTRK3 and Medulloblastoma
|
Grotzer MA, et al. TrkC Expression Predicts Good Clinical Outcome in Primitive Neuroectodermal Brain Tumors. J Clin Oncol 2000;18(5):1027 Related articles (PubMed)
Segal RA, et al. Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma Proc Natl Acad Sci USA. 1994; 91(26):12867-71 Related articles (PubMed)
Kim JY, et al. Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. Cancer Res. 1999; 59(3):711-9 Related articles (PubMed)
Medline Search: medulloblastoma AND (trkc OR ntrk3) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Childhood Brain Tumours Genetics
Return to NTRK3 Contents
|
| t(12;15)(p13;q25) in Congenital Fibrosarcoma
|
The t(12;15)(p13;q25) fusing the ETV6 and NTRK3 genes has been reported in congenital (infantile) fibrosarcoma. In an RT-PCR study of paediatric tumours (Bourgeois, 2000), the ETV6-NTRK3 fusion transcripts were detected in 10/11 congenital fibrosarcomas
compared to 0/13 other malignant spindle cell tumours and 0/38 benign spindle cell tumours. The authors suggest RT-PCR assays to detect the ETV6-NTRK3 gene fusion will be useful in the diagnosis of congenital fibrosarcoma and in particular to
differentiation from more aggressive spindle cell sarcomas including adult-type fibrosarcoma.
Bourgeois JM, et al. Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. Am J Surg Pathol 2000 Jul;24(7):937-46 Related articles (PubMed)
Liu Q, et al. Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia. EMBO J 2000 Apr 17;19(8):1827-38 Related articles (PubMed)
Wai DH, et al. The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells. Oncogene 2000 Feb 17;19(7):906-15 Related articles (PubMed)
Knezevich SR, et al. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet 1998 Feb;18(2):184-7 Related articles (PubMed)
Medline Search: congenital fibrosarcoma AND translocation (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Childhood Soft Tissue Sarcoma Genetics
Childhood Soft Tissue Sarcoma : Clinical and Epidemiological Information
Return to NTRK3 Contents
|
|
[Home] This page created: 23/11/1999 Last revised: 29/04/2003 © Copyright 1999-
|
