Chromosome 15

Genes Linked with Cancer (58)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 15; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
PWAR1 15q11.2 PAR1, PAR-1, D15S227E-Breast Cancer
-Lung Cancer
-Prostate Cancer
SNRPN 15q11.2 SMN, PWCR, SM-D, sm-N, RT-LI, HCERN3, SNRNP-N, SNURF-SNRPN-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
-Testicular Cancer
OCA2 15q12-q13.1 P, BEY, PED, BEY1, BEY2, BOCA, EYCL, HCL3, EYCL2, EYCL3, SHEP1, D15S12-Melanoma
-Skin Cancer
-Basal Cell Carcinoma (BCC) - Skin
TJP1 15q13.1 ZO-1-Breast Cancer
-Colorectal Cancer
-Leukaemia
-Lung Cancer
GREM1 15q13.3 DRM, HMPS, MPSH, PIG2, CRAC1, CRCS4, DAND2, HMPS1, IHG-2, DUP15q, C15DUPq, GREMLIN, CKTSF1B1-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Skin Cancer
THBS1 15q14 TSP, THBS, TSP1, TSP-1, THBS-1-Breast Cancer
-Colorectal Cancer
-Eye Cancer
-Gallbladder Cancer
-Lung Cancer
-Mesothelioma
SPRED1 15q14 NFLS, hSpred1, spred-1, PPP1R147-Acute Myeloid Leukaemia
-Prostate Cancer
NUTM1 15q14 NUT, FAM22H, C15orf55Somatic
KNL1 15q15.1 D40, CT29, Spc7, CASC5, MCPH4, hKNL-1, AF15Q14, PPP1R55, hSpc105Somatic-Leukaemia
-Melanoma
-Testicular Cancer
BUB1B 15q15.1 MVA1, SSK1, BUBR1, Bub1A, MAD3L, hBUBR1, BUB1betaGermline-Breast Cancer
-Prostate Cancer
-Wilms Tumour
DLL4 15q15.1 AOS6, hdelta2-Brain Tumours, Childhood
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Thyroid Cancer
KNSTRN 15q15.1 SKAP, HSD11, C15orf23, TRAF4AF1Somatic-Squamous Cell Carcinoma - Skin
RAD51 15q15.1 RECA, BRCC5, FANCR, MRMV2, HRAD51, RAD51A, HsRad51, HsT16930-Breast Cancer
-Eye Cancer
-Lung Cancer
-Ovarian Cancer
TYRO3 15q15.1 BYK, Dtk, RSE, Rek, Sky, Tif, Etk-2-Acute Myeloid Leukaemia
-Brain Tumours, Childhood
-Breast Cancer
-Melanoma
-Multiple Myeloma
-Ovarian Cancer
-Uterine Sarcoma
TP53BP1 15q15.3 TP53, p202, 53BP1, TDRD30, p53BP1-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
HMGN2P46 15q21.1 D-PCa-2, C15orf21Somatic-Prostate Cancer
B2M 15q21.1 IMD43-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Liver Cancer
-Multiple Myeloma
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
CYP19A1 15q21.2 ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM-Breast Cancer
-Cervical Cancer
-Ovarian Cancer
-Stomach Cancer
-Testicular Cancer
-Uterine Sarcoma
FGF7 15q21.2 KGF, HBGF-7-Bladder Cancer
-Breast Cancer
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
-Thyroid Cancer
NEDD4 15q21.3 RPF1, NEDD4-1-Breast Cancer
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
ADAM10 15q21.3 RAK, kuz, AD10, AD18, MADM, CD156c, CDw156, HsT18717-Breast Cancer
-Liver Cancer
-Uterine Sarcoma
TCF12 15q21.3 HEB, CRS3, HTF4, TCF-12, bHLHb20, HsT17266Somatic-Bone Cancer (primary)
-Brain Tumours, Childhood
-Chondrosarcoma
-Leukaemia
-Soft Tissue Sarcoma
C15orf65 15q21.3 Somatic
CCNB2 15q22.2 HsT17299-Breast Cancer
-Lung Cancer
-Osteosarcoma
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
TPM1 15q22.2 CMH3, TMSA, CMD1Y, LVNC9, C15orf13, HEL-S-265, HTM-alpha-Brain Tumours, Childhood
-Breast Cancer
-Colorectal Cancer
-Kidney Cancer
-Lung Cancer
-Stomach Cancer
CA12 15q22.2 CAXII, CA-XII, T18816, HsT18816-Breast Cancer
-Cervical Cancer
-Kidney Cancer
-Liver Cancer
-Ovarian Cancer
-Thyroid Cancer
-Vulvar Cancer
ANXA2 15q22.2 P36, ANX2, LIP2, LPC2, CAL1H, LPC2D, ANX2L4, PAP-IV, HEL-S-270-Breast Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
-Vaginal Cancer
MAP2K1 15q22.31 CFC3, MEK1, MKK1, MAPKK1, PRKMK1-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Stomach Cancer
-Thyroid Cancer
-von Hippel-Lindau Disease
DAPK2 15q22.31 DRP1, DRP-1-Bladder Cancer
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Skin Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
-Thyroid Cancer
PDCD7 15q22.31 ES18, HES18-Acute Myeloid Leukaemia
SMAD6 15q22.31 AOVD2, MADH6, MADH7, HsT17432-Brain Tumours, Childhood
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Pancreatic Cancer
-Uterine Sarcoma
SMAD3 15q22.33 LDS3, LDS1C, MADH3, JV15-2, HSPC193, HsT17436-Breast Cancer
-Liver Cancer
ANP32A 15q23 LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1-Brain Tumours, Childhood
-Pancreatic Cancer
-Prostate Cancer
CYP1A2 15q24.1 CP12, P3-450, P450(PA)-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
-Testicular Cancer
CD276 15q24.1 B7H3, B7-H3, B7RP-2, 4Ig-B7-H3-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Neuroblastoma
-Ovarian Cancer
-Pancreatic Cancer
-Skin Cancer
-Stomach Cancer
PML 15q24.1 MYL, RNF71, PP8675, TRIM19Somatic
Translocation
-Acute Myeloid Leukaemia
-Leukaemia
CSK 15q24.1 -Breast Cancer
-Colorectal Cancer
-Prostate Cancer
CYP1A1 15q24.1 AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Small Cell Lung Cancer
-Prostate Cancer
-Uterine Sarcoma
CYP11A1 15q24.1 CYP11A, CYPXIA1, P450SCC-Adrenocortical Cancer
-Breast Cancer
-Prostate Cancer
SIN3A 15q24.2 WITKOS-Breast Cancer
IMP3 15q24.2 BRMS2, MRPS4, C15orf12-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Oral Cavity Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
-Testicular Cancer
-Thyroid Cancer
IL16 15q25.1 LCF, NIL16, PRIL16, prIL-16-Brain Tumours, Childhood
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Kidney Cancer
-Prostate Cancer
-Skin Cancer
-Stomach Cancer
CHRNA5 15q25.1 LNCR2-Lung Cancer
-Lung Cancer, Non-Small Cell
-Stomach Cancer
CHRNA3 15q25.1 LNCR2, PAOD2, NACHRA3-Lung Cancer
-Lung Cancer, Non-Small Cell
CRABP1 15q25.1 RBP5, CRABP, CRABPI, CRABP-I-Colorectal Cancer
-Ovarian Cancer
CHRNB4 15q25.1 -Bladder Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
BCL2A1 15q25.1 GRS, ACC1, ACC2, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5-Leukaemia
-Melanoma
-Oral Cavity Cancer
AKAP13 15q25.3 BRX, LBC, p47, HA-3, Ht31, c-lbc, PRKA13, AKAP-13, AKAP-Lbc, ARHGEF13, PROTO-LB, PROTO-LBC-Breast Cancer
NTRK3 15q25.3 TRKC, GP145-TrkC, gp145(trkC)Somatic
Translocation
-Breast Cancer
-Medulloblastoma
-Neuroblastoma
-Salivary Gland Cancer
-Soft Tissue Sarcoma, Childhood
-Stomach Cancer
-Wilms Tumour
CRTC3 15q26.1 TORC3, TORC-3Somatic-Breast Cancer
-Salivary Gland Cancer
-Skin Cancer
BLM 15q26.1 BS, RECQ2, RECQL2, RECQL3Germline-Bloom Syndrome
-Breast Cancer
-Colorectal Cancer
-Melanoma
-Skin Cancer
FANCI 15q26.1 KIAA1794Germline-Fanconi Anaemia
PRC1 15q26.1 ASE1-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Skin Cancer
-Stomach Cancer
-Thyroid Cancer
IDH2 15q26.1 IDH, IDP, IDHM, IDPM, ICD-M, D2HGA2, mNADP-IDHSomatic-Acute Myeloid Leukaemia
-Astrocytoma, Childhood
-Bone Cancer (primary)
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
FES 15q26.1 FPS-Acute Myeloid Leukaemia
-Breast Cancer
-Leukaemia
FURIN 15q26.1 FUR, PACE, SPC1, PCSK3-Breast Cancer
-Lung Cancer
-Skin Cancer
IQGAP1 15q26.1 SAR1, p195, HUMORFA01-Brain and CNS Tumours
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Stomach Cancer
IGF1R 15q26.3 IGFR, CD221, IGFIR, JTK13-Breast Cancer
-Lung Cancer
-Small Cell Lung Cancer
-Neuroblastoma
-Prostate Cancer
-Thyroid Cancer
-Wilms Tumour

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 15:

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.

Further Resources (3 links)

Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.

Cite this page: Cotterill SJ. Chromosome 15, Cancer Genetics Web: http://www.cancer-genetics.org/clinkc15.htm Accessed:

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