Chromosome 15

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 15; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
CASC5 15q14 D40, CT29, KNL1, Spc7, hKNL-1, AF15Q14, PPP1R55, hSpc105Somatic
NUTM1 15q14 NUT, FAM22H, C15orf55Somatic
THBS1 15q15 TSP, THBS, TSP1, TSP-1, THBS-1
TP53BP1 15q15-q21 p202, 53BP1-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
BUB1B 15q15 MVA1, SSK1, BUBR1, Bub1A, MAD3L, hBUBR1, BUB1betaGermline
KNSTRN 15q15.1 SKAP, HSD11, C15orf23, TRAF4AF1Somatic-Squamous Cell Carcinoma - Skin
B2M 15q21-q22.2
TCF12 15q21 HEB, CRS3, HTF4, bHLHb20, HsT17266Somatic
CYP19A1 15q21.1 ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM
HMGN2P46 15q21.1 D-PCa-2, C15orf21Somatic
C15orf65 15q21.3 Somatic
PML 15q22 MYL, RNF71, PP8675, TRIM19Somatic
PDCD7 15q22.31 ES18, HES18
AKAP13 15q24-q25 BRX, LBC, p47, HA-3, Ht31, c-lbc, PRKA13, AKAP-13, AKAP-Lbc, ARHGEF13, PROTO-LB, PROTO-LBC
CYP1A1 15q24.1 AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
CSK 15q24.1
BCL2A1 15q24.3 GRS, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5-Leukaemia
-Oral Cavity Cancer
NTRK3 15q25 TRKC, gp145(trkC)Somatic
-Breast Cancer
-Salivary Gland Cancer
-Soft Tissue Sarcoma, Childhood
-Stomach Cancer
-Wilms Tumour
CRTC3 15q26.1 TORC3, TORC-3Somatic
IDH2 15q26.1 IDH, IDP, IDHM, IDPM, ICD-M, D2HGA2, mNADP-IDHSomatic
FES 15q26.1 FPS
BLM 15q26.1 BS, RECQ2, RECQL2, RECQL3Germline
FANCI 15q26.1 KIAA1794Germline-Fanconi Anaemia
IGF1R 15q26.3 IGFR, CD221, IGFIR, JTK13

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 15:

Abnormality Type Gene(s)
t(12;15)(p13;q25) ETV6-NTRK3 in Breast CancerTranslocationNTRK3 (15q25)ETV6 (12p13)
t(12;15)(p13;q25) ETV6-NTRK3 in Congenital FibrosarcomaTranslocationNTRK3 (15q25)ETV6 (12p13)
t(12;15)(p13;q25) ETV6-NTRK3 in congenital mesoblastic nephromaTranslocationNTRK3 (15q25)ETV6 (12p13)
t(15;17)(q21;q21) RARA-PML translocation in Acute Promyelocytic LeukaemiaTranslocationPML (15q22)RARA (17q21)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.

Further Resources (2 links)


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