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  Chromosome 15

Genes Linked with Cancer (56)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 15; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
NEDD4 15q RPF1, NEDD4-1-Breast Cancer
-Pancreatic Cancer
-Prostate Cancer
OCA2 15q P, BEY, PED, BEY1, BEY2, BOCA, EYCL, HCL3, EYCL2, EYCL3, SHEP1, D15S12-Melanoma
-Skin Cancer
-Basal Cell Carcinoma (BCC) - Skin
SNRPN 15q11.2 SMN, PWCR, SM-D, sm-N, RT-LI, HCERN3, SNRNP-N, SNURF-SNRPN-Breast Cancer
-Ovarian Cancer
PWAR1 15q11.2 PAR1, PAR-1, D15S227E-Breast Cancer
-Lung Cancer
-Prostate Cancer
TJP1 15q13 ZO-1-Breast Cancer
-Colorectal Cancer
-Leukaemia
-Lung Cancer
GREM1 15q13.3 DRM, HMPS, MPSH, PIG2, CRAC1, CRCS4, DAND2, HMPS1, IHG-2, DUP15q, C15DUPq, GREMLIN, CKTSF1B1-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Skin Cancer
DLL4 15q14 hdelta2-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Thyroid Cancer
CASC5 15q14 D40, CT29, KNL1, Spc7, hKNL-1, AF15Q14, PPP1R55, hSpc105Somatic-Leukaemia
-Melanoma
-Testicular Cancer
NUTM1 15q14 NUT, FAM22H, C15orf55Somatic
THBS1 15q15 TSP, THBS, TSP1, TSP-1, THBS-1-Breast Cancer
-Colorectal Cancer
-Eye Cancer
-Gallbladder Cancer
-Lung Cancer
-Mesothelioma
BUB1B 15q15 MVA1, SSK1, BUBR1, Bub1A, MAD3L, hBUBR1, BUB1betaGermline-Breast Cancer
-Prostate Cancer
-Wilms Tumour
TP53BP1 15q15-q21 p202, 53BP1-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
TYRO3 15q15 BYK, Dtk, RSE, Rek, Sky, Tif, Etk-2-Acute Myeloid Leukaemia
-Brain Tumours, Childhood
-Breast Cancer
-Melanoma
-Uterine Sarcoma
RAD51 15q15.1 RECA, BRCC5, MRMV2, HRAD51, RAD51A, HsRad51, HsT16930-Breast Cancer
-Eye Cancer
-Ovarian Cancer
KNSTRN 15q15.1 SKAP, HSD11, C15orf23, TRAF4AF1Somatic-Squamous Cell Carcinoma - Skin
TCF12 15q21 HEB, CRS3, HTF4, bHLHb20, HsT17266Somatic-Bone Cancer (primary)
-Chondrosarcoma
-Leukaemia
-Soft Tissue Sarcoma
B2M 15q21-q22.2 -Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Multiple Myeloma
-Prostate Cancer
CYP19A1 15q21.1 ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM-Breast Cancer
-Cervical Cancer
-Ovarian Cancer
-Testicular Cancer
-Uterine Sarcoma
HMGN2P46 15q21.1 D-PCa-2, C15orf21Somatic-Prostate Cancer
FGF7 15q21.2 KGF, HBGF-7-Bladder Cancer
-Breast Cancer
-Pancreatic Cancer
-Prostate Cancer
-Thyroid Cancer
C15orf65 15q21.3 Somatic
ADAM10 15q22 RAK, kuz, AD10, AD18, MADM, CD156c, HsT18717-Breast Cancer
-Liver Cancer
-Uterine Sarcoma
CA12 15q22 CAXII, HsT18816-Breast Cancer
-Cervical Cancer
-Kidney Cancer
-Liver Cancer
-Ovarian Cancer
-Thyroid Cancer
-Vulvar Cancer
PML 15q22 MYL, RNF71, PP8675, TRIM19Somatic
Translocation
-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
MAP2K1 15q22.1-q22.33 CFC3, MEK1, MKK1, MAPKK1, PRKMK1-Thyroid Cancer
-von Hippel-Lindau Disease
CCNB2 15q22.2 HsT17299-Breast Cancer
-Lung Cancer
-Osteosarcoma
-Ovarian Cancer
-Prostate Cancer
ANXA2 15q22.2 P36, ANX2, LIP2, LPC2, CAL1H, LPC2D, ANX2L4, PAP-IV, HEL-S-270-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
-Vaginal Cancer
DAPK2 15q22.31 DRP1, DRP-1-Bladder Cancer
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Skin Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
-Thyroid Cancer
PDCD7 15q22.31 ES18, HES18-Acute Myeloid Leukaemia
SMAD6 15q22.31 AOVD2, MADH6, MADH7, HsT17432-Brain Tumours, Childhood
-Colorectal Cancer
-Lung Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Uterine Sarcoma
SMAD3 15q22.33 LDS3, LDS1C, MADH3, JV15-2, HSPC193, HsT17436-Breast Cancer
-Liver Cancer
ANP32A 15q23 LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1-Brain Tumours, Childhood
-Pancreatic Cancer
-Prostate Cancer
CD276 15q23-q24 B7H3, B7-H3, B7RP-2, 4Ig-B7-H3-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Neuroblastoma
-Ovarian Cancer
-Pancreatic Cancer
-Skin Cancer
CYP11A1 15q23-q24 CYP11A, CYPXIA1, P450SCC-Adrenocortical Cancer
-Breast Cancer
-Prostate Cancer
IMP3 15q24 BRMS2, MRPS4, C15orf12-Bladder Cancer
-Breast Cancer
-Oral Cavity Cancer
-Prostate Cancer
CHRNB4 15q24 -Bladder Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
CRABP1 15q24 RBP5, CRABP, CRABPI, CRABP-I-Colorectal Cancer
-Ovarian Cancer
CHRNA5 15q24 LNCR2-Lung Cancer
-Lung Cancer, Non-Small Cell
-Stomach Cancer
CHRNA3 15q24 LNCR2, PAOD2, NACHRA3-Lung Cancer
-Lung Cancer, Non-Small Cell
AKAP13 15q24-q25 BRX, LBC, p47, HA-3, Ht31, c-lbc, PRKA13, AKAP-13, AKAP-Lbc, ARHGEF13, PROTO-LB, PROTO-LBC-Breast Cancer
CYP1A1 15q24.1 AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Uterine Sarcoma
CSK 15q24.1 -Breast Cancer
-Colorectal Cancer
-Prostate Cancer
CYP1A2 15q24.1 CP12, P3-450, P450(PA)-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
-Testicular Cancer
SIN3A 15q24.2 -Breast Cancer
BCL2A1 15q24.3 GRS, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5-Leukaemia
-Melanoma
-Oral Cavity Cancer
NTRK3 15q25 TRKC, gp145(trkC)Somatic
Translocation
-Medulloblastoma
-Breast Cancer
-Neuroblastoma
-Salivary Gland Cancer
-Soft Tissue Sarcoma, Childhood
-Stomach Cancer
-Wilms Tumour
CRTC3 15q26.1 TORC3, TORC-3Somatic-Breast Cancer
-Childhood Cancers
-Salivary Gland Cancer
FANCI 15q26.1 KIAA1794Germline-Fanconi Anaemia
IDH2 15q26.1 IDH, IDP, IDHM, IDPM, ICD-M, D2HGA2, mNADP-IDHSomatic-Acute Myeloid Leukaemia
-Astrocytoma, Childhood
-Bone Cancer (primary)
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Childhood Cancers
BLM 15q26.1 BS, RECQ2, RECQL2, RECQL3Germline-Breast Cancer
-Melanoma
-Skin Cancer
FES 15q26.1 FPS-Acute Myeloid Leukaemia
-Breast Cancer
-Leukaemia
PRC1 15q26.1 ASE1-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Skin Cancer
IQGAP1 15q26.1 SAR1, p195, HUMORFA01-Brain and CNS Tumours
-Breast Cancer
-Liver Cancer
-Stomach Cancer
FURIN 15q26.1 FUR, PACE, SPC1, PCSK3-Breast Cancer
-Skin Cancer
IGF1R 15q26.3 IGFR, CD221, IGFIR, JTK13-Breast Cancer
-Lung Cancer
-Small Cell Lung Cancer
-Neuroblastoma
-Prostate Cancer
-Thyroid Cancer
-Wilms Tumour
IL16 15q26.3 LCF, NIL16, PRIL16, prIL-16-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Kidney Cancer
-Prostate Cancer
-Skin Cancer
-Stomach Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 15:

Abnormality Type Gene(s)
t(12;15)(p13;q25) ETV6-NTRK3 in Breast CancerTranslocationNTRK3 (15q25)ETV6 (12p13)
t(12;15)(p13;q25) ETV6-NTRK3 in Congenital FibrosarcomaTranslocationNTRK3 (15q25)ETV6 (12p13)
t(12;15)(p13;q25) ETV6-NTRK3 in congenital mesoblastic nephromaTranslocationNTRK3 (15q25)ETV6 (12p13)
t(15;17)(q21;q21) RARA-PML translocation in Acute Promyelocytic LeukaemiaTranslocationPML (15q22)RARA (17q21)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

Further Resources


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Cite this page: Cotterill SJ. Chromosome 15, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc15.htm Accessed: date

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