 Summary Information
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Location: 12p13
Alias: TEL
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| Gene Database Entries for ETV6
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OMIM
GeneCard (Weizmann Institute)
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for ETV6)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (ETV6[TI] OR TEL[TI]) (PubMed)
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| ETV6 Rearangements in Haematological Malignancies
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Wlodarska I, et al. ETV6 gene rearrangements in hematopoietic malignant disorders [Review] Leuk Lymphoma 1996; 23(3-4):287-95 Related articles (PubMed)
Medline Search: cancer AND (tel OR etv6) (PubMed)
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| t(12;21) TEL-AML1 Translocation in Leukaemia
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Medline Search: leukemia AND (TEL-AML1 OR 12;21) (PubMed)
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| t(12;21) in Childhood Acute Lymphoblastic Leukaemia
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The t(12;21)(p13;q22), TEL-AML1 translocation, is observed in approximately 20-25% of childhood B-lineage acute lymphoblastic leukemia (ALL) cases in both Asian and Caucasian populations (Kobayashi H et al., 1997). It is the most frequent known genetic
abnormality in childhood B-cell ALL.
Wiemels JL, Greaves M Structure and possible mechanisms of TEL-AML1 gene fusions in childhood acute lymphoblastic leukemia. Cancer Res 1999; 59:4075-82 Related articles (PubMed)
Kobayashi H. et al. Detection of the Der (21)t(12;21) chromosome forming the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia. (Review) Leuk Lymphoma 1997; 28:43-50 Related articles (PubMed)
Medline Search: child AND leukemia AND (TEL-AML1 OR 12;21) (PubMed)
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 CBFA2 (AML1) gene- ETV6 (TEL) gene
Childhood Leukaemia Genetics
Childhood Leukaemia : Clinical and Epidemiological Information
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| t(12;21) in Adult Lyphocytic Leukaemias
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The t(12;21)(p13;q22), TEL-AML1 translocation, is observed in approximately 3% of adult acute lymphoblastic leukaemias (ALL) while it occurs in about a quarter of childhood B-cell ALL cases.
Aguiar RC. et al. TEL-AML1 fusion in acute lymphoblastic leukaemia of adults. M.R.C. Adult Leukaemia Working Party. Br J Haematol. 1996; 95:673-7 Related articles (PubMed)
Kwong YL, Wong KF Low frequency of TEL/AML1 in adult acute lymphoblastic leukemia. Cancer Genet Cytogenet 1997; 98:137-8 Related articles (PubMed)
Hoshino K. et al. TEL/AML1 fusion gene resulting from a cryptic t(12;21) is uncommon in adult patients with B-cell lineage ALL and CML lymphoblastic transformation. Int J Hematol 1997; 66:213-8 Related articles (PubMed)
Medline Search: adult AND leukemia AND (TEL-AML1 OR 12;21) (PubMed)
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- CBFA2 (AML1) gene
- ETV6 (TEL) gene
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| t(5;12)(q33;p13) in Chronic Myelomonocytic Leukemia
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Chronic myelomonocytic leukaemia (CMML) is a myelodysplastic syndrome and is characterized dysplastic monocytosis, hypercellular bone marrow, splenomegaly, and progression to acute myelogenous leukemia (AML). A sub-set of CMMLs have a t(5;12)(q33;p13)
balanced translocation involving the PDGFRB and ETV6 (TEL) genes.
Golub TR, et al. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994; 77(2):307-16 Related articles (PubMed)
Carroll M, et al. The TEL/platelet-derived growth factor beta receptor (PDGF beta Proc Natl Acad Sci USA. 1996; 93(25):14845-50 Related articles
Medline Search: chronic myelomonocytic leukemia AND (pdgfr OR pdgfrb) (PubMed)
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Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| ETV6 - ABL Rearangements in Leukaemia
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Hannemann JR, et al. Haemopoietic transformation by the TEL/ABL oncogene. Br J Haematol. 1998; 102(2):475-85 Related articles (PubMed)
Hannemann JR, et al. The second ETV6 allele is not necessarily deleted in acute leukemias with a ETV6/ABL fusion. Genes Chromosomes Cancer 1998; 21(3):256-9 Related articles (PubMed)
Medline Search: leukemia AND (tel[TI] OR etv6[TI]) AND abl (PubMed)
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Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| t(1;12)(q25;p13) in Acute Myeloid Leukaemia
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Cazzaniga G, et al. The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts. Blood 1999 Dec 15;94(12):4370-3 Related articles (PubMed)
Iijima Y, et al. A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation. Blood 2000 Mar 15;95(6):2126-31 Related articles (PubMed)
Medline Search: acute myeloid leukemia AND translocation AND (arg OR abl2) AND (etv6 OR tel) (PubMed)
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Acute Myeloid Leukaemia Genetics
Acute Myeloid Leukaemia : Clinical and Epidemiological Information
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| t(12;15)(p13;q25) in Congenital Fibrosarcoma
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The t(12;15)(p13;q25) fusing the ETV6 and NTRK3 genes has been reported in congenital (infantile) fibrosarcoma. In an RT-PCR study of paediatric tumours (Bourgeois, 2000), the ETV6-NTRK3 fusion transcripts were detected in 10/11 congenital fibrosarcomas
compared to 0/13 other malignant spindle cell tumours and 0/38 benign spindle cell tumours. The authors suggest RT-PCR assays to detect the ETV6-NTRK3 gene fusion will be useful in the diagnosis of congenital fibrosarcoma and in particular to
differentiation from more aggressive spindle cell sarcomas including adult-type fibrosarcoma.
Bourgeois JM, et al. Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. Am J Surg Pathol 2000 Jul;24(7):937-46 Related articles (PubMed)
Liu Q, et al. Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia. EMBO J 2000 Apr 17;19(8):1827-38 Related articles (PubMed)
Wai DH, et al. The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells. Oncogene 2000 Feb 17;19(7):906-15 Related articles (PubMed)
Knezevich SR, et al. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet 1998 Feb;18(2):184-7 Related articles (PubMed)
Medline Search: congenital fibrosarcoma AND translocation (PubMed)
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Childhood Soft Tissue Sarcoma Genetics
Childhood Soft Tissue Sarcoma : Clinical and Epidemiological Information
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