Mutated Genes and Abnormal Protein Expression (6)
Recurrent Chromosome Abnormalities (2)
Overview of Chronic Myelogenous Leukemia
Chronic Myeloid Leukaemia: Clinical and Epidemiological Resources

Philadelphia Chromosome in Chronic Myelogenous Leukaemia
t(7;11)(p15;p15) in Chronic Myelogenous Leukaemia

Chronic myelogenous leukemia (CML) is characterised by the Philadelphia (Ph) chromosome which is seen in over 95% of patients. The Ph chromosome results from a reciprocal translocation between the long arms of chromosomes 9 and 22, this fuses the ABL1 from chromosome 9 to the BCR gene on chromosome 22. The median age of patients with Ph+ CML is 67 years of age, it can occasionally occur in children (2-3% of all childhood leukaemias).

Faderl S, et al. The biology of chronic myeloid leukemia. N Engl J Med 1999 Jul 15;341(3):164-72    Related articles (PubMed)

Kurzrock R, et al. The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med 1988 Oct 13;319(15):990-8    Related articles (PubMed)

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Chronic Myeloid Leukaemia Genetics
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