|Gene:||CBLC; Cbl proto-oncogene C|
|Aliases:||CBL-3, RNF57, CBL-SL|
|Summary:||This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]|
|Databases:||VEGA, OMIM, HGNC, Ensembl, GeneCard, Gene|
|Protein:||E3 ubiquitin-protein ligase CBL-C|
|Source:||NCBIAccessed: 11 March, 2017|
What does this gene/protein do?
|Pathways:||What pathways are this gene/protein implicaed in?|
Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.
Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Breast Cancer||CBLC and Breast Cancer||View Publications||1|
|Lung Cancer||CBLC and Lung Cancer||View Publications||1|
|Chronic Myelogenous Leukemia||CBLC and Chronic Myelogenous Leukemia||View Publications||1|
|Lung Cancer, Non-Small Cell||CBLC and Non-Small Cell Lung Cancer||View Publications||1|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.
Cite this page: Cotterill SJ. CBLC, Cancer Genetics Web: http://www.cancer-genetics.org/CBLC.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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[Home] Page last revised: 11 March, 2017 Cancer Genetics Web, Established 1999