IRF4 - Interferon regulatory factor 4 - aka: MUM1, LSIRF

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IRF4; Interferon regulatory factor 4 (6p25-p23)
IRF4 Menu Summary Information - IRF4 Gene Database Entries for IRF4 Other IRF4 Related Resources t(6;14)(p25;q32) in Multiple Myeloma t(6;14)(p25,q32) in Lymphomas IRF4 Expression in Chronic Myeloid Leukemia Feedback / suggest a new topic for IRF4
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Summary Information
IRF4; Interferon regulatory factor 4 Location: 6p25-p23 Aliases: MUM1, LSIRF aka Multiple myeloma oncogene 1 Return to IRF4 Contents
Gene Database Entries for IRF4
OMIM GeneCard (Weizmann Institute) Genbank Swiss-Prot Locus Link UniGene GenAtlas GDB Nomenclature (search for IRF4) Return to IRF4 Contents
Other Related Resources
Search Medline for related articles (PubMed) *Medline Search:* cancer AND gene AND (IRF4[TI] OR MUM1[TI] OR LSIRF[TI]) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to IRF4 Contents
t(6;14)(p25;q32) in Multiple Myeloma
Yoshida S, et al. Detection of MUM1/IRF4-IgH fusion in multiple myeloma Leukemia 1999;13(11):1812-6 Related articles (PubMed) Iida S, et al. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma Nat Genet 1997;17(2):226-30 Related articles (PubMed) *Medline Search:* multiple myeloma AND translocation AND (MUM1 OR IRF4) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Multiple Myeloma Genetics Multiple Myeloma : Clinical and Epidemiological Information Return to IRF4 Contents
t(6;14)(p25,q32) in Lymphomas
Tsuboi K, et al. MUM1/IRF4 expression as a frequent event in mature lymphoid malignancies Leukemia 2000;14(3):449-56 Related articles (PubMed) *Medline Search:* lymphoma AND translocation AND (MUM1 OR IRF4) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Non-Hodgkin's Lymphoma Genetics Non-Hodgkin's Lymphoma : Clinical and Epidemiological Information Return to IRF4 Contents
IRF4 Expression in Chronic Myeloid Leukemia
Schmidt and colleagues (JCO, 2000) found that IRF4 was significantly downregulated in patients with CML compared to health subjects. Increasing IRF4 expression was associated with a favourable response to interferon Alfa therapy. This suggests that IRF4 expression may be a useful marker to monitor response to interferon Alfa in patients with CML. Schmidt, et al. Expression of Interferon Regulatory Factor 4 in Chronic Myeloid Leukemia: Correlation With Response to Interferon Alfa Therapy J Clin Oncol 2000;18: 3331-3338 *Medline Search:* chronic myeloid leukemia AND (interferon regulatory factor 4 OR IRF4) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Chronic Myeloid Leukaemia Genetics Chronic Myeloid Leukaemia : Clinical and Epidemiological Information Return to IRF4 Contents
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IRF4; Interferon regulatory factor 4