TERC - Telomerase RNA component - aka: hTR, TRC3

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TERC; Telomerase RNA component (3q21-q28)
TERC Menu Summary Information - TERC Gene Database Entries for TERC Other TERC Related Resources Telomerase and Cancer TERC and Lung Cancer TERC Expression in Neuroblastoma Feedback / suggest a new topic for TERC
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Summary Information
TERC; Telomerase RNA component Location: 3q21-q28 Aliases: hTR, TRC3 Return to TERC Contents
Gene Database Entries for TERC
OMIM GeneCard (Weizmann Institute) Genbank Locus Link GenAtlas GDB Nomenclature (search for TERC) Return to TERC Contents
Other Related Resources
Search Medline for related articles (PubMed) *Medline Search:* cancer AND gene AND (TERC[TI] OR hTR[TI] OR TRC3[TI]) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to TERC Contents
Telomerase and Cancer
Telomerase is an enzyme that adds TTAGGG nucleotide repeats onto the ends of vertebrate chromosomal DNA (telomeres) to compensate for losses that occur with each round of DNA replication. Normal somatic cells do not have telomerase activity and stop dividing when the telomeric ends of the chromosomes have been shortened to a critical length. It is thought that some cancer cells become "immortalized" because they express telomerase and can therefore continue to proliferate indefinitely. Feng J, et al. The RNA component of human telomerase. Science 1995; 269(5228):1236-41 Related articles (PubMed) Avilion AA, et al. Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res. 1996; 56(3):645-50 Related articles (PubMed) Soder AI, et al. Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer. Oncogene 1997; 14(9):1013-21 Related articles (PubMed) *Medline Search:* telomerase AND cancer (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Resources by Disease Type Return to TERC Contents
TERC and Lung Cancer
Unlike normal lung tissues, some lung cancers express telomerase. A number of studies suggest that telomerase expression is an adverse prognostic factor for lung cancers. In a study of 91 lung tumours (Sarvesvaran, 1999) found that upregulation of the RNA component of telomerase occured in 98% of SCLCs. They suggest that SCLC would be a prime target for therapies directed at the RNA component of human telomerase. Sarvesvaran J, et al. Is small cell lung cancer the perfect target for anti-telomerase treatment? Carcinogenesis 1999; 20(8):1649-51 Related articles (PubMed) Hiyama K, et al. Telomerase activity in small-cell and non-small-cell lung cancers. J Natl Cancer Inst 1995; 87(12):895-902 Related articles (PubMed) *Medline Search:* lung cancer AND telomerase (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Lung Cancer Genetics Lung Cancer : Clinical and Epidemiological Information Return to TERC Contents
TERC Expression in Neuroblastoma
*Medline Search:* telomerase AND neuroblastoma (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Neuroblastoma Genetics Neuroblastoma : Clinical and Epidemiological Information Return to TERC Contents
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TERC; Telomerase RNA component