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  Chromosome 5

Genes Linked with Cancer (90)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 5; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
LIFR 5p13-p12 SWS, SJS2, STWS, CD118, LIF-RSomatic
IL7R 5p13 ILRA, CD127, IL7RA, CDW127, IL-7R-alphaSomatic-Acute Lymphocytic Leukaemia (ALL)
-Acute Lymphocytic Leukemia (ALL), child
SKP2 5p13 p45, FBL1, FLB1, FBXL1-Breast Cancer
-Ewing's Sarcoma
-Lung Cancer
-Prostate Cancer
-Skin Cancer
AMACR 5p13 RM, RACE, CBAS4, AMACRD-Kidney Cancer
-Prostate Cancer
RICTOR 5p13.1 PIA, AVO3, hAVO3-Breast Cancer
PTGER4 5p13.1 EP4, EP4R-Colorectal Cancer
-Lung Cancer
DAB2 5p13.1 DOC2, DOC-2-Ovarian Cancer
-Prostate Cancer
-Uterine Sarcoma
GDNF 5p13.1-p12 ATF1, ATF2, HSCR3, HFB1-GDNF-Adrenocortical Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Multiple Endocrine Neoplasia Type 2a
-Pheochromocytoma and Paraganglioma
PRLR 5p13.2 HPRL, MFAB, hPRLrI-Breast Cancer
-Prostate Cancer
DROSHA 5p13.3 RN3, ETOHI2, RNASEN, RANSE3L, RNASE3L, HSA242976-Breast Cancer
-Ewing's Sarcoma
-Eye Cancer
-Small Cell Lung Cancer
-Skin Cancer
-Stomach Cancer
-Testicular Cancer
-Wilms Tumour
SDHA 5p15 FP, PGL5, SDH1, SDH2, SDHF, CMD1GG-Adrenocortical Cancer
-Gastrointestinal Cancers
-Gastrointestinal Stromal Tumors
-Head and Neck Cancers
-Kidney Cancer
-Pheochromocytoma and Paraganglioma
-von Hippel-Lindau Disease
SRD5A1 5p15 S5AR 1-Breast Cancer
-Prostate Cancer
CMBL 5p15.2 JS-1-Breast Cancer
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
TRIO 5p15.2 tgat, ARHGEF23-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
MTRR 5p15.31 MSR, cblE-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
CLPTM1L 5p15.33 CRR9-Cervical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Skin Cancer
PDCD6 5p15.33 ALG2, ALG-2, PEF1B-Cervical Cancer
-Colorectal Cancer
-Eye Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
TERT 5p15.33 TP2, TRT, CMM9, EST2, TCS1, hTRT, DKCA2, DKCB4, hEST2, PFBMFT1-Acute Myeloid Leukaemia
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Melanoma
-Thyroid Cancer
MSH3 5q11-q12 DUP, MRP1-Colorectal Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Skin Cancer
-Thyroid Cancer
IL6ST 5q11.2 CD130, GP130, CDW130, IL-6RBSomatic-Breast Cancer
-Liver Cancer
-Multiple Myeloma
MAP3K1 5q11.2 MEKK, MEKK1, SRXY6, MEKK 1, MAPKKK1-Breast Cancer
DHFR 5q11.2-q13.2 DYR, DHFRP1-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
-Uterine Sarcoma
ITGA1 5q11.2 VLA1, CD49a
CCNB1 5q12 CCNB-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Small Cell Lung Cancer
CDK7 5q12.1 CAK1, HCAK, MO15, STK1, CDKN7, p39MO15-Breast Cancer
POLK 5q13 DINP, POLQ, DINB1-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Pituitary Tumors
OCLN 5q13.1 BLCPMG, PPP1R115-Breast Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
PIK3R1 5q13.1 p85, AGM7, GRB1, IMD36, p85-ALPHASomatic-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Endometrial Cancer
-Stomach Cancer
XRCC4 5q14.2 -Breast Cancer
-Cervical Cancer
-Lung Cancer
MEF2C 5q14.3 DEL5q14.3, C5DELq14.3-Acute Lymphocytic Leukaemia (ALL)
VCAN 5q14.3 WGN, ERVR, GHAP, PG-M, WGN1, CSPG2-Colorectal Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
-Skin Cancer
-Uterine Sarcoma
CAST 5q15 BS-17-Breast Cancer
-Kidney Cancer
-Lung Cancer
-Melanoma
-Pancreatic Cancer
-Prostate Cancer
-Wilms Tumour
APC 5q21-q22 GS, DP2, DP3, BTPS2, DP2.5, PPP1R46Germline & Somatic-Adenomatous Polyposis Coli
-Colorectal Cancer
-Skin Cancer
-Stomach Cancer
-Thyroid Cancer
FER 5q21 FerT, TYK3, Pe1Fe3, Pe1Fe6, PPP1R74, Pe1Fe10, Pe1Fe13-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
MCC 5q21 MCC1-Adenomatous Polyposis Coli
-Colorectal Cancer
-Lung Cancer
-Merkel Cell Carcinoma
-Stomach Cancer
-Testicular Cancer
NEUROG1 5q23-q31 AKA, ngn1, Math4C, bHLHa6, NEUROD3-Colorectal Cancer
-Retinoblastoma
GPX3 5q23 GPx-P, GSHPx-3, GSHPx-P-Esophageal Cancer
-Prostate Cancer
-Stomach Cancer
-Thyroid Cancer
LOX 5q23.2 -Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
CXCL14 5q31 KEC, KS1, BMAC, BRAK, NJAC, MIP2G, MIP-2g, SCYB14-Breast Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
SMAD5 5q31 DWFC, JV5-1, MADH5-Acute Myeloid Leukaemia
-Brain Tumours, Childhood
-Colorectal Cancer
-Ovarian Cancer
-Prostate Cancer
RAD50 5q31 NBSLD, RAD502, hRad50-Breast Cancer
-Colorectal Cancer
SKP1 5q31 OCP2, p19A, EMC19, SKP1A, OCP-II, TCEB1L-Breast Cancer
-Lung Cancer
-Prostate Cancer
-von Hippel-Lindau Disease
ADRB2 5q31-q32 BAR, B2AR, ADRBR, ADRB2R, BETA2AR-Breast Cancer
-Melanoma
-Pancreatic Cancer
-Prostate Cancer
-Uterine Sarcoma
TGFBI 5q31 CSD, CDB1, CDG2, CSD1, CSD2, CSD3, EBMD, LCD1, BIGH3, CDGG1-Kidney Cancer
-Lung Cancer
-Ovarian Cancer
-Pancreatic Cancer
HDAC3 5q31 HD3, RPD3, RPD3-2-Breast Cancer
-Colorectal Cancer
AFF4 5q31 MCEF, AF5Q31Somatic
Translocation
-Acute Lymphocytic Leukemia (ALL), child
-Leukaemia
FGF1 5q31 AFGF, ECGF, FGFA, ECGFA, ECGFB, FGF-1, HBGF1, HBGF-1, GLIO703, ECGF-beta, FGF-alpha-Bladder Cancer
-Breast Cancer
-Prostate Cancer
-Salivary Gland Cancer
-Uterine Sarcoma
ITK 5q31-q32 EMT, LYK, LPFS1, PSCTK2Somatic
ARHGAP26 5q31 GRAF, GRAF1, OPHN1L, OPHN1L1Somatic-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Childhood Cancers
-Chronic Myelogenous Leukemia
-Leukaemia
-Lung Cancer
-Myelodysplastic Syndromes
CDC25C 5q31 CDC25, PPP1R60-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
IL13 5q31 P600, IL-13-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Hodgkin Lymphoma
-Kaposi Sarcoma
-Stomach Cancer
IL4 5q31.1 BSF1, IL-4, BCGF1, BSF-1, BCGF-1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Kaposi Sarcoma
-Melanoma
-Non-Hodgkin Lymphoma
-Skin Cancer
-Stomach Cancer
-Waldenstrom's Macroglobulinemia
IL12B 5q31.1-q33.1 CLMF, NKSF, CLMF2, IMD28, IMD29, NKSF2, IL-12B-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
-Melanoma
-Vulvar Cancer
TCF7 5q31.1 TCF-1-Colorectal Cancer
-Liver Cancer
ACSL6 5q31.1 ACS2, FACL6, LACS2, LACS5, LACS 6Somatic-Acute Myeloid Leukaemia
-Leukaemia
IRF1 5q31.1 MAR, IRF-1-Breast Cancer
-Stomach Cancer
EGR1 5q31.1 TIS8, AT225, G0S30, NGFI-A, ZNF225, KROX-24, ZIF-268-Acute Myeloid Leukaemia
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Prostate Cancer
-Uterine Sarcoma
-Wilms Tumour
PDLIM4 5q31.1 RIL-Breast Cancer
-Prostate Cancer
CD14 5q31.1 -Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Leukaemia
-Prostate Cancer
PPP2CA 5q31.1 RP-C, PP2Ac, PP2CA, PP2Calpha-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Skin Cancer
-Wilms Tumour
MZB1 5q31.2 PACAP, pERp1, MEDA-7Somatic
CTNNA1 5q31.2 CAP102-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
HINT1 5q31.2 HINT, NMAN, PKCI-1, PRKCNH1-Colorectal Cancer
-Liver Cancer
-Skin Cancer
-Stomach Cancer
SPRY4 5q31.3 HH17-Germ Cell Tumours
-Ovarian Cancer
-Testicular Cancer
SPARC 5q31.3-q32 ON-Brain Tumours, Childhood
-Breast Cancer
-Esophageal Cancer
-Lung Cancer
-Melanoma
-Osteosarcoma
-Pancreatic Cancer
-Skin Cancer
-Thyroid Cancer
NR3C1 5q31.3 GR, GCR, GRL, GCCR, GCRST-Acute Lymphocytic Leukaemia (ALL)
-Multiple Myeloma
LARS 5q32 LRS, LEUS, LFIS, ILFS1, LARS1, LEURS, PIG44, RNTLS, HSPC192, hr025Cl-Acute Myeloid Leukaemia
-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Melanoma
-Skin Cancer
CSF1R 5q32 FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R-Acute Myeloid Leukaemia
-Leukaemia
CD74 5q32 II, DHLAG, HLADG, Ia-GAMMASomatic-Breast Cancer
-Childhood Cancers
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Mycosis Fungoides
CCNG1 5q32-q34 CCNG-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Pancreatic Cancer
-Rectal Cancer
CDX1 5q32 -Colorectal Cancer
-Stomach Cancer
SPINK1 5q32 TCP, PCTT, PSTI, TATI, Spink3-Bladder Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
FAT2 5q33.1 CDHF8, CDHR9, HFAT2, MEGF1-Esophageal Cancer
PDGFRB 5q33.1 IMF1, IBGC4, JTK12, PDGFR, CD140B, PDGFR1, PDGFR-1Somatic
Translocation
-Brain Tumours, Childhood
-Leukaemia
NKX2-5 5q34 CSX, CSX1, VSD3, CHNG5, HLHS2, NKX2E, NKX2.5, NKX4-1-Breast Cancer
-Prostate Cancer
EBF1 5q34 EBF, COE1, OLF1, O/E-1Somatic-Acute Lymphocytic Leukaemia (ALL)
-Childhood Cancers
DUSP1 5q34 HVH1, MKP1, CL100, MKP-1, PTPN10-Breast Cancer
-Cervical Cancer
-Lung Cancer
RANBP17 5q34 Somatic-Acute Lymphocytic Leukaemia (ALL)
-Childhood Cancers
MAML1 5q35 Mam1, Mam-1-Brain Tumours, Childhood
-Breast Cancer
-Cervical Cancer
SQSTM1 5q35 p60, p62, A170, OSIL, PDB3, ZIP3, p62B-Breast Cancer
-Lung Cancer
NSD1 5q35 STO, KMT3B, SOTOS, ARA267, SOTOS1Somatic-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
-Prostate Cancer
-Skin Cancer
NPM1 5q35.1 B23, NPMSomatic
Translocation
-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
-Myelodysplastic Syndromes
-Non-Hodgkin Lymphoma
PTTG1 5q35.1 EAP1, PTTG, HPTTG, TUTR1-Breast Cancer
-Liver Cancer
-Pituitary Tumors
-Thyroid Cancer
RARS 5q35.1 ArgRS, DALRD1-Acute Myeloid Leukaemia
-Breast Cancer
-Lung Cancer
-Myelodysplastic Syndromes
TLX3 5q35.1 RNX, HOX11L2Somatic-Acute Lymphocytic Leukaemia (ALL)
-Childhood Cancers
-Leukaemia
FGFR4 5q35.2 TKF, JTK2, CD334-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
MSX2 5q35.2 FPP, MSH, PFM, CRS2, HOX8, PFM1-Breast Cancer
FLT4 5q35.3 PCL, FLT41, LMPH1A, VEGFR3-Soft Tissue Sarcoma
GNB2L1 5q35.3 H12.3, HLC-7, PIG21, RACK1, Gnb2-rs1-Breast Cancer
SCGB3A1 5q35.3 HIN1, HIN-1, LU105, UGRP2, PnSP-2-Breast Cancer
-Lung Cancer
-Testicular Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 5:

Abnormality Type Gene(s)
CD74-ROS1 fusion in NSCLCFusionCD74 (5q32)ROS1 (6q22)
FIG-ROS1 Fusion in NSCLCFusionROS1 (6q22)
CD74-NTRK1 fusion in Lung CancerTranslocationCD74 (5q32)NTRK1 (1q21-q22)
t(2;5)(p23;q35) NPM1-ALK translocation in Anaplastic large cell lymphomaTranslocationNPM1 (5q35.1)ALK (2p23)
t(5;17)(q32;q11) RARA-NPM translocations in Acute Promyelocytic LeukemiaTranslocationNPM1 (5q35.1)RARA (17q21)
t(5;12)(q33;p13) in Chronic Myelomonocytic LeukemiaTranslocationPDGFRB (5q33.1)ETV6 (12p13)
ins(5;11)(q31;q31q23) MLL-AFF4 in Infant Acute lymphoblastic LeukemiaTranslocationAFF4 (5q31)KMT2A (11q23)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

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Cite this page: Cotterill SJ. Chromosome 5, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc05.htm Accessed: date

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