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  Chromosome 5

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 5; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
IL7R 5p13 ILRA, CD127, IL7RA, CDW127, IL-7R-alphaSomatic
LIFR 5p13-p12 SWS, SJS2, STWS, CD118, LIF-RSomatic
DAB2 5p13.1 DOC2, DOC-2-Ovarian Cancer
-Prostate Cancer
-Uterine Sarcoma
CLPTM1L 5p15.33 CRR9-Cervical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Skin Cancer
TERT 5p15.33 TP2, TRT, CMM9, EST2, TCS1, hTRT, DKCA2, DKCB4, hEST2, PFBMFT1-Acute Myeloid Leukaemia
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Melanoma
-Thyroid Cancer
PDCD6 5p15.33 ALG-2, PEF1B
IL6ST 5q11.2 CD130, GP130, CDW130, IL-6RBSomatic
ITGA1 5q11.2 VLA1, CD49a
PIK3R1 5q13.1 p85, AGM7, GRB1, p85-ALPHASomatic
XRCC4 5q14.2
MCC 5q21 MCC1
FER 5q21 FerT, TYK3, Pe1Fe3, Pe1Fe6, PPP1R74, Pe1Fe10, Pe1Fe13
APC 5q21-q22 GS, DP2, DP3, BTPS2, DP2.5, PPP1R46Germline & Somatic-Thyroid Cancer
FGF1 5q31 AFGF, ECGF, FGFA, ECGFA, ECGFB, FGF-1, HBGF1, HBGF-1, GLIO703, ECGF-beta, FGF-alpha
AFF4 5q31 MCEF, AF5Q31Somatic
Translocation
-Acute Lymphocytic Leukemia (ALL), child
-Leukaemia
ARHGAP26 5q31 GRAF, GRAF1, OPHN1L, OPHN1L1Somatic
ITK 5q31-q32 EMT, LYK, LPFS1, PSCTK2Somatic
ACSL6 5q31.1 ACS2, FACL6, LACS2, LACS5, LACS 6Somatic
IL12B 5q31.1-q33.1 CLMF, NKSF, CLMF2, NKSF2, IL-12B
IL4 5q31.1 BSF1, IL-4, BCGF1, BSF-1, BCGF-1
MZB1 5q31.2 PACAP, pERp1, MEDA-7Somatic
SPARC 5q31.3-q32 ON
CD74 5q32 II, DHLAG, HLADG, Ia-GAMMASomatic-Breast Cancer
-Childhood Cancers
-Lung Cancer
-Mycosis Fungoides
CSF1R 5q32 FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R
PDGFRB 5q33.1 IMF1, IBGC4, JTK12, PDGFR, CD140B, PDGFR1, PDGFR-1Somatic
Translocation
-Leukaemia
EBF1 5q34 EBF, COE1, OLF1, O/E-1Somatic
RANBP17 5q34 Somatic
NSD1 5q35 STO, KMT3B, SOTOS, ARA267, SOTOS1Somatic
SQSTM1 5q35 p60, p62, A170, OSIL, PDB3, ZIP3, p62B-Breast Cancer
-Lung Cancer
PTTG1 5q35.1 EAP1, PTTG, HPTTG, TUTR1
NPM1 5q35.1 B23, NPMSomatic
Translocation
-Leukaemia
-Non-Hodgkin Lymphoma
TLX3 5q35.1 RNX, HOX11L2Somatic

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 5:

Abnormality Type Gene(s)
CD74-ROS1 fusion in NSCLCFusionCD74 (5q32)ROS1 (6q22)
FIG-ROS1 Fusion in NSCLCFusionROS1 (6q22)
CD74-NTRK1 fusion in Lung CancerTranslocationCD74 (5q32)NTRK1 (1q21-q22)
t(2;5)(p23;q35) NPM1-ALK translocation in Anaplastic large cell lymphomaTranslocationNPM1 (5q35.1)ALK (2p23)
t(5;17)(q32;q11) RARA-NPM translocations in Acute Promyelocytic LeukemiaTranslocationNPM1 (5q35.1)RARA (17q21)
t(5;12)(q33;p13) in Chronic Myelomonocytic LeukemiaTranslocationPDGFRB (5q33.1)ETV6 (12p13)
ins(5;11)(q31;q31q23) MLL-AFF4 in Infant Acute lymphoblastic LeukemiaTranslocationAFF4 (5q31)KMT2A (11q23)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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