Chromosome 5

Genes Linked with Cancer (99)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 5; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
SELENOP 5p12 SeP, SELP, SEPP, SEPP1-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Liver Cancer
-Prostate Cancer
FGF10 5p12 -Breast Cancer
-Lung Cancer
-Prostate Cancer
LIFR 5p13.1 SWS, SJS2, STWS, CD118, LIF-RSomatic
DAB2 5p13.1 DOC2, DOC-2-Ovarian Cancer
-Prostate Cancer
-Uterine Sarcoma
RICTOR 5p13.1 PIA, AVO3, hAVO3-Breast Cancer
-Prostate Cancer
PTGER4 5p13.1 EP4, EP4R-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
SKP2 5p13.2 p45, FBL1, FLB1, FBXL1-Breast Cancer
-Ewing's Sarcoma
-Lung Cancer
-Prostate Cancer
-Skin Cancer
AMACR 5p13.2 RM, RACE, CBAS4, P504S, AMACRD-Kidney Cancer
-Prostate Cancer
IL7R 5p13.2 ILRA, CD127, IL7RA, CDW127, IL-7R-alphaSomatic-Acute Lymphocytic Leukaemia (ALL)
-Acute Lymphocytic Leukemia (ALL), child
GDNF 5p13.2 ATF, ATF1, ATF2, HSCR3, HFB1-GDNF-Adrenocortical Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Multiple Endocrine Neoplasia Type 2a
-Pheochromocytoma and Paraganglioma
-Stomach Cancer
PRLR 5p13.2 HPRL, MFAB, hPRLrI-Breast Cancer
-Prostate Cancer
DROSHA 5p13.3 RN3, ETOHI2, RNASEN, RANSE3L, RNASE3L, HSA242976-Breast Cancer
-Ewing's Sarcoma
-Eye Cancer
-Lung Cancer
-Small Cell Lung Cancer
-Ovarian Cancer
-Skin Cancer
-Stomach Cancer
-Testicular Cancer
-Thyroid Cancer
-Wilms Tumour
CMBL 5p15.2 JS-1-Breast Cancer
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
TRIO 5p15.2 tgat, MEBAS, MRD44, ARHGEF23-Breast Cancer
-Liver Cancer
-Ovarian Cancer
-Prostate Cancer
SRD5A1 5p15.31 S5AR 1-Breast Cancer
-Prostate Cancer
MTRR 5p15.31 MSR, cblE-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Stomach Cancer
TERT 5p15.33 TP2, TRT, CMM9, EST2, TCS1, hTRT, DKCA2, DKCB4, hEST2, PFBMFT1-Acute Myeloid Leukaemia
-Adrenocortical Cancer
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Melanoma
-Thyroid Cancer
SDHA 5p15.33 FP, PGL5, SDH1, SDH2, SDHF, CMD1GG-Adrenocortical Cancer
-Gastrointestinal Cancers
-Gastrointestinal Stromal Tumors
-Head and Neck Cancers
-Kidney Cancer
-Pheochromocytoma and Paraganglioma
-von Hippel-Lindau Disease
CLPTM1L 5p15.33 CRR9-Cervical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Skin Cancer
PDCD6 5p15.33 ALG2, ALG-2, PEF1B-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Eye Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Ovarian Cancer
IL6ST 5q11.2 CD130, GP130, CDW130, IL-6RBSomatic-Breast Cancer
-Liver Cancer
-Small Cell Lung Cancer
-Multiple Myeloma
-Stomach Cancer
MAP3K1 5q11.2 MEKK, MEKK1, SRXY6, MEKK 1, MAPKKK1-Breast Cancer
PLK2 5q11.2 SNK, hSNK, hPlk2-Acute Myeloid Leukaemia
-Bladder Cancer
-Ovarian Cancer
-Stomach Cancer
ITGA1 5q11.2 VLA1, CD49a
PIK3R1 5q13.1 p85, AGM7, GRB1, IMD36, p85-ALPHASomatic-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Endometrial Cancer
-Stomach Cancer
OCLN 5q13.2 BLCPMG, PPP1R115-Breast Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
RAD17 5q13.2 CCYC, R24L, RAD24, HRAD17, RAD17SP-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Prostate Cancer
CDK7 5q13.2 CAK, CAK1, HCAK, MO15, STK1, CDKN7, p39MO15-Breast Cancer
-Lung Cancer
-Neuroblastoma
CCNB1 5q13.2 CCNB-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Small Cell Lung Cancer
POLK 5q13.3 DINP, POLQ, DINB1-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pituitary Tumors
DHFR 5q14.1 DYR, DHFRP1-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
-Uterine Sarcoma
MSH3 5q14.1 DUP, FAP4, MRP1-Colorectal Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Skin Cancer
-Thyroid Cancer
VCAN 5q14.2-q14.3 WGN, ERVR, GHAP, PG-M, WGN1, CSPG2-Colorectal Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
-Skin Cancer
-Uterine Sarcoma
XRCC4 5q14.2 SSMED-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Lung Cancer
MEF2C 5q14.3 DEL5q14.3, C5DELq14.3-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Leukaemia
-Liver Cancer
CAST 5q15 BS-17, PLACK-Breast Cancer
-Kidney Cancer
-Lung Cancer
-Melanoma
-Pancreatic Cancer
-Prostate Cancer
-Wilms Tumour
FER 5q21.3 TYK3, PPP1R74, p94-Fer-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
MCC 5q22.2 MCC1-Adenomatous Polyposis Coli
-Colorectal Cancer
-Lung Cancer
-Merkel Cell Carcinoma
-Stomach Cancer
-Testicular Cancer
APC 5q22.2 GS, DP2, DP3, BTPS2, DP2.5, PPP1R46Germline & Somatic-Adenomatous Polyposis Coli
-Colorectal Cancer
-Skin Cancer
-Stomach Cancer
-Thyroid Cancer
-Turcot Syndrome
LOX 5q23.1 AAT10-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
HINT1 5q23.3 HINT, NMAN, PKCI-1, PRKCNH1-Chronic Myelogenous Leukemia
-Colorectal Cancer
-Liver Cancer
-Skin Cancer
-Stomach Cancer
NEUROG1 5q31.1 AKA, ngn1, Math4C, bHLHa6, NEUROD3-Colorectal Cancer
-Eye Cancer
-Retinoblastoma
SMAD5 5q31.1 DWFC, JV5-1, MADH5-Acute Myeloid Leukaemia
-Brain Tumours, Childhood
-Colorectal Cancer
-Ovarian Cancer
-Prostate Cancer
SKP1 5q31.1 OCP2, p19A, EMC19, SKP1A, OCP-II, TCEB1L-Breast Cancer
-Lung Cancer
-Prostate Cancer
-von Hippel-Lindau Disease
PDLIM4 5q31.1 RIL-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
TGFBI 5q31.1 CSD, CDB1, CDG2, CSD1, CSD2, CSD3, EBMD, LCD1, BIGH3, CDGG1-Kidney Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
-Pancreatic Cancer
PPP2CA 5q31.1 RP-C, PP2Ac, PP2CA, PP2Calpha-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Melanoma
-Prostate Cancer
-Skin Cancer
-Wilms Tumour
TCF7 5q31.1 TCF-1-Bone Cancer (primary)
-Colorectal Cancer
-Liver Cancer
-Pancreatic Cancer
RAD50 5q31.1 NBSLD, RAD502, hRad50-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
AFF4 5q31.1 MCEF, CHOPS, AF5Q31Somatic
Translocation
-Acute Lymphocytic Leukemia (ALL), child
-Leukaemia
ACSL6 5q31.1 ACS2, FACL6, LACS2, LACS5, LACS 6Somatic-Acute Myeloid Leukaemia
-Leukaemia
IL4 5q31.1 BSF1, IL-4, BCGF1, BSF-1, BCGF-1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Kaposi Sarcoma
-Melanoma
-Non-Hodgkin Lymphoma
-Skin Cancer
-Stomach Cancer
-Waldenstrom's Macroglobulinemia
CXCL14 5q31.1 KEC, KS1, BMAC, BRAK, NJAC, MIP2G, MIP-2g, SCYB14-Breast Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
IRF1 5q31.1 MAR, IRF-1-Breast Cancer
-Stomach Cancer
IL13 5q31.1 P600, IL-13-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Hodgkin Lymphoma
-Kaposi Sarcoma
-Stomach Cancer
PITX1 5q31.1 BFT, CCF, POTX, PTX1, LBNBG-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pituitary Tumors
-Stomach Cancer
-Testicular Cancer
EGR1 5q31.2 TIS8, AT225, G0S30, NGFI-A, ZNF225, KROX-24, ZIF-268-Acute Myeloid Leukaemia
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Prostate Cancer
-Uterine Sarcoma
-Wilms Tumour
MZB1 5q31.2 PACAP, pERp1, MEDA-7Somatic
CDC25C 5q31.2 CDC25, PPP1R60-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
CTNNA1 5q31.2 MDPT2, CAP102-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
ARHGAP26 5q31.3 GRAF, GRAF1, OPHN1L, OPHN1L1Somatic-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Brain Tumours, Childhood
-Chronic Myelogenous Leukemia
-Leukaemia
-Lung Cancer
-Myelodysplastic Syndromes
-Prostate Cancer
HBEGF 5q31.3 DTR, DTS, DTSF, HEGFL-Breast Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
SPRY4 5q31.3 HH17-Germ Cell Tumours
-Melanoma
-Ovarian Cancer
-Skin Cancer
-Stomach Cancer
-Testicular Cancer
FGF1 5q31.3 AFGF, ECGF, FGFA, ECGFA, ECGFB, FGF-1, HBGF1, HBGF-1, GLIO703, ECGF-beta, FGF-alpha-Bladder Cancer
-Breast Cancer
-Prostate Cancer
-Salivary Gland Cancer
-Uterine Sarcoma
HDAC3 5q31.3 HD3, RPD3, RPD3-2-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Thyroid Cancer
CD14 5q31.3 -Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Leukaemia
-Prostate Cancer
NR3C1 5q31.3 GR, GCR, GRL, GCCR, GCRST-Acute Lymphocytic Leukaemia (ALL)
-Multiple Myeloma
-Prostate Cancer
-Stomach Cancer
LARS 5q32 LRS, LEUS, LFIS, ILFS1, LARS1, LEURS, PIG44, RNTLS, HSPC192, hr025Cl-Acute Myeloid Leukaemia
-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Melanoma
-Prostate Cancer
-Skin Cancer
ADRB2 5q32 BAR, B2AR, ADRBR, ADRB2R, BETA2AR-Breast Cancer
-Melanoma
-Pancreatic Cancer
-Prostate Cancer
-Uterine Sarcoma
SPINK1 5q32 TCP, PCTT, PSTI, TATI, Spink3-Bladder Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
CSF1R 5q32 FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R-Acute Myeloid Leukaemia
-Kidney Cancer
-Leukaemia
-Myelodysplastic Syndromes
CDX1 5q32 -Colorectal Cancer
-Stomach Cancer
PDGFRB 5q32 IMF1, KOGS, IBGC4, JTK12, PDGFR, PENTT, CD140B, PDGFR1, PDGFR-1Somatic
Translocation
-Bladder Cancer
-Brain Tumours, Childhood
-Kaposi Sarcoma
-Leukaemia
-Salivary Gland Cancer
-Skin Cancer
-Soft Tissue Sarcoma
CD74 5q33.1 II, DHLAG, HLADG, Ia-GAMMASomatic-Breast Cancer
-Chronic Lymphocytic Leukemia
-Kidney Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Mycosis Fungoides
SPARC 5q33.1 ON, OI17, BM-40-Brain Tumours, Childhood
-Breast Cancer
-Esophageal Cancer
-Lung Cancer
-Melanoma
-Osteosarcoma
-Pancreatic Cancer
-Skin Cancer
-Thyroid Cancer
FAT2 5q33.1 CDHF8, CDHR9, HFAT2, MEGF1-Esophageal Cancer
GPX3 5q33.1 GPx-P, GSHPx-3, GSHPx-P-Esophageal Cancer
-Prostate Cancer
-Stomach Cancer
-Thyroid Cancer
HAVCR2 5q33.3 TIM3, CD366, KIM-3, TIMD3, Tim-3, TIMD-3, HAVcr-2-Acute Myeloid Leukaemia
-Liver Cancer
-Melanoma
-Pancreatic Cancer
-Stomach Cancer
EBF1 5q33.3 EBF, COE1, OLF1, O/E-1Somatic-Acute Lymphocytic Leukaemia (ALL)
ITK 5q33.3 EMT, LYK, LPFS1, PSCTK2Somatic
IL12B 5q33.3 CLMF, NKSF, CLMF2, IMD28, IMD29, NKSF2, IL-12B-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
-Melanoma
-Stomach Cancer
-Vulvar Cancer
PTTG1 5q33.3 EAP1, PTTG, HPTTG, TUTR1-Breast Cancer
-Esophageal Cancer
-Liver Cancer
-Lung Cancer
-Pituitary Tumors
-Thyroid Cancer
CCNG1 5q34 CCNG-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Osteosarcoma
-Pancreatic Cancer
-Rectal Cancer
HMMR 5q34 CD168, IHABP, RHAMM-Acute Myeloid Leukaemia
-Breast Cancer
-Lung Cancer
-Prostate Cancer
RARS 5q34 HLD9, ArgRS, DALRD1-Acute Myeloid Leukaemia
-Breast Cancer
-Lung Cancer
-Myelodysplastic Syndromes
NPM1 5q35.1 B23, NPMSomatic
Translocation
-Acute Myeloid Leukaemia
-Leukaemia
-Myelodysplastic Syndromes
-Non-Hodgkin Lymphoma
NKX2-5 5q35.1 CSX, CSX1, VSD3, CHNG5, HLHS2, NKX2E, NKX2.5, NKX4-1-Breast Cancer
-Prostate Cancer
TLX3 5q35.1 RNX, HOX11L2Somatic-Acute Lymphocytic Leukaemia (ALL)
-Leukaemia
RANBP17 5q35.1 Somatic-Acute Lymphocytic Leukaemia (ALL)
DUSP1 5q35.1 HVH1, MKP1, CL100, MKP-1, PTPN10-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
MSX2 5q35.2 FPP, MSH, PFM, CRS2, HOX8, PFM1-Breast Cancer
FGFR4 5q35.2 TKF, JTK2, CD334-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
MIR1271 5q35.2 MIRN1271, hsa-mir-1271-Head and Neck Cancers
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
SQSTM1 5q35.3 p60, p62, A170, DMRV, OSIL, PDB3, ZIP3, p62B, NADGP, FTDALS3-Breast Cancer
-Lung Cancer
NSD1 5q35.3 STO, KMT3B, SOTOS, ARA267, SOTOS1Somatic-Acute Myeloid Leukaemia
-Breast Cancer
-Leukaemia
-Myelodysplastic Syndromes
-Prostate Cancer
-Skin Cancer
RACK1 5q35.3 H12.3, HLC-7, PIG21, GNB2L1, Gnb2-rs1-Breast Cancer
-Esophageal Cancer
MAML1 5q35.3 Mam1, Mam-1-Brain Tumours, Childhood
-Breast Cancer
-Cervical Cancer
-Esophageal Cancer
FLT4 5q35.3 PCL, FLT-4, FLT41, LMPH1A, VEGFR3, VEGFR-3-Breast Cancer
-Colorectal Cancer
-Kidney Cancer
-Leukaemia
-Soft Tissue Sarcoma
SCGB3A1 5q35.3 HIN1, HIN-1, LU105, UGRP2, PnSP-2-Breast Cancer
-Lung Cancer
-Testicular Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 5:

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.

Further Resources (3 links)

Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.

Cite this page: Cotterill SJ. Chromosome 5, Cancer Genetics Web: http://www.cancer-genetics.org/clinkc05.htm Accessed:

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