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APC; Adenomatosis polyposis coli (5q21-q22)
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    Summary Information - APC
    Gene Database Entries for APC
    Other APC Related Resources
    APC and Familial Adenomatous Polyposis
       - APC and Attenuated Adenomatous Polyposis Coli
    APC and Colon Cancer
       - APC I1307K Polymorphism in Colorectal Cancer
    APC and Desmoid Tumor (aggressive fibromatoses)
    APC and Adrenocortical Carcinoma (FAP Associated)
    APC and Bladder Cancer
    APC and Hepatoblastoma (FAP Associated)
    APC and Thyroid Cancer (FAP Associated)
    APC and Gastric Cancer
       - APC and FAP Associated Gastric Cancer
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  Summary Information

APC; Adenomatosis polyposis coli

Location: 5q21-q22

Aliases: FPC, DP2

Overview: The APC gene is mutated in people with Familial Adenomatous Polyposis (FAP). FAP is an autosomal dominant disorder causing extensive adenomatous polyps of the colon and early onset colorectal cancer.

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  Gene Database Entries for APC

OMIM
GeneCard (Weizmann Institute)
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Human Gene Mutation Database (Cardiff, UK)
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for APC)

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  Other Related Resources


Universal APC Database (Universal Mutation Database) Large referenced database by Christophe Béroud and Thierry Soussi, Institute Curie, France
Colon Cancer Resources
MCC (5q21)

  • Medline Search: APC (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
    Search Medline for related articles (PubMed)
  • Medline Search: cancer AND gene AND (APC[TI] OR FPC[TI] OR DP2[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
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  •   APC and Familial Adenomatous Polyposis

    Familial Adenomatous Polyposis (FAP) is an autosomal dominant disorder causing extensive adenomatous polyps in the colon and early onset colorectal cancer.The disorder is characterised by mutation of the APC gene . FAP is also assciated with elevated risk of extracolonic tumours (previously refered to as Gardner syndrome) including hepatoblastoma and thyroid carcinoma.

  • Lamlum H, et al. The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis. Nat Med. 1999; 5(9):1071-5    Related articles (PubMed)

  • Medline Search: apc AND gene AND familial adenomatous polyposis (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   APC and Attenuated Adenomatous Polyposis Coli

  • Soravia C, et al. Genotype-phenotype correlations in attenuated adenomatous polyposis coli. Am J Hum Genet 1998; 62(6):1290-301    Related articles (PubMed)

  • van der Luijt RB, et al. Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli. Hum Genet. 1996; 98(6):727-34    Related articles (PubMed)

  • Medline Search: apc AND attenuated adenomatous polyposis coli (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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  •   APC and Colon Cancer

  • Gryfe R, et al. Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism. Am J Hum Genet. 1999;64(2):378-84.    Related articles (PubMed)

  • Miyaki M, et al. Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer. Cancer Res 1999; 59(18):4506-9    Related articles (PubMed)

  • Medline Search: APC AND colon cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    CTNNB1 gene
    ColoRectal Cancers Genetics
    ColoRectal Cancers : Clinical and Epidemiological Information

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  •   APC I1307K Polymorphism in Colorectal Cancer

  • Gryfe R, et al. Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism. Am J Hum Genet. 1999;64(2):378-84.    Related articles (PubMed)

  • Laken SJ, et al. Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet 1997 Sep;17(1):79-83    Related articles (PubMed)

  • Medline Search: colorectal cancer AND (I1307K OR Ashkenazi) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    ColoRectal Cancers Genetics
    ColoRectal Cancers : Clinical and Epidemiological Information

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  •   APC and Desmoid Tumor (aggressive fibromatoses)

  • Tejpar S, et al. Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor). Oncogene. 1999; 18(47):6615-20    Related articles (PubMed)

  • Halling KC, et al. Hereditary desmoid disease in a family with a germline Alu I repeat mutation of the APC gene. Hum Hered 1999; 49(2):97-102    Related articles (PubMed)

  • Alman BA, et al. Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). Am J Pathol. 1997; 151(2):329-34    Related articles (PubMed)

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  •   APC and Adrenocortical Carcinoma (FAP Associated)

  • Wakatsuki S, et al. Adrenocortical tumor in a patient with familial adenomatous polyposis: a case associated with a complete inactivating mutation of the APC gene and unusual histological features. [Review] Hum Pathol. 1998; 29(3):302-6    Related articles (PubMed)

  • Seki M, et al. Loss of normal allele of the APC gene in an adrenocortical carcinoma from a patient with familial adenomatous polyposis. Hum Genet. 1992; 89(3):298-300    Related articles (PubMed)

  • Medline Search: adrenocortical tumor AND APC (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Adrenocortical Carcinoma Genetics
    Adrenocortical Carcinoma : Clinical and Epidemiological Information

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  •   APC and Bladder Cancer

  • Bohm M. et al. Deletion analysis at the DEL-27, APC and MTS1 loci in bladder cancer: LOH at the DEL-27 locus on 5p13-12 is a prognostic marker of tumor progression. Int J Cancer 1997 Jun 20;74(3):291-5    Related articles (PubMed)

  • Medline Search: APC AND bladder cancer (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources

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  •   APC and Hepatoblastoma (FAP Associated)

  • Hughes LJ, Michels VV Risk of hepatoblastoma in familial adenomatous polyposis Am J Med Genet 1992; 43(6):1023-5    Related articles (PubMed)

  • Giardiello FM, et al. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. Gut 1996; 39(96):867-9    Related articles (PubMed)

  • Medline Search: hepatoblastoma AND familial adenomatous polyposis (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Hepatoblastoma Genetics
    Hepatoblastoma : Clinical and Epidemiological Information

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  •   APC and Thyroid Cancer (FAP Associated)

  • Cetta F, et al. Genetic alterations in thyroid carcinoma associated with familial adenomatous polyposis: clinical implications and suggestions for early detection. World J Surg 1998; 22(12):1231-6    Related articles (PubMed)

  • Harach HR, et al. Familial adenomatous polyposis associated thyroid carcinoma: a distinct type of follicular cell neoplasm. Histopathology. 1994;25(6):549-61. [Review]    Related articles (PubMed)

  • Medline Search: thyroid cancer AND apc AND gene (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Thyroid Cancer Genetics
    Thyroid Cancer : Clinical and Epidemiological Information

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  •   APC and Gastric Cancer

  • Park WS, et al. Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer. Cancer Res 1999; 59(17):4257-60    Related articles (PubMed)

  • Medline Search: gastric cancer AND apc (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Stomach (Gastric) Cancer Genetics
    Stomach (Gastric) Cancer : Clinical and Epidemiological Information

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  •   APC and FAP Associated Gastric Cancer

  • Enomoto M, et al. The relationship between frequencies of extracolonic manifestations and the position of APC germline mutation in patients with familial adenomatous polyposis. Jpn J Clin Oncol 2000 Feb;30(2):82-8    Related articles (PubMed)

  • Park WS, et al. Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer. Cancer Res 1999; 59(17):4257-60    Related articles (PubMed)

  • Medline Search: gastric cancer AND (apc OR familial adenomatous polyposis) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Stomach (Gastric) Cancer Genetics
    Stomach (Gastric) Cancer : Clinical and Epidemiological Information

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