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  Non-Melanoma Skin Cancer

Mutated Genes and Abnormal Protein Expression (10)
Recurrent Chromosome Abnormalities (1)
Genetics of Basal Cell Carcinoma
  Mutated Genes and Abnormal Protein Expression
GeneLocationTopics
CD44 ( MDU3 , HA , MDU2 ) 11pter-p13 -CD44 and Skin Cancer
CDKN2A ( P16 , INK4A , MTS1 ) 9p21 -CDKN2A Mutations in Non-Melanoma Skin Cancer
MMP11 ( STMY3 , STR3 ) 22q11.2 -MMP11 Expression in Cutaneous Squamous Cell Carcinoma
MMP12 ( HME ) 11q22.2-q22.3 -MMP12 Expression in Non-Melanoma Skin Cancers
MSH2 ( HNPCC1 , COCA1 , FCC1 ) 2p22-p21 -MSH2 Upregulation in Basal Cell Carcinoma
PCNA20p12 -PCNA and Skin Cancer
PDGFB ( SIS ) 22q12.3-q13.1 -t(17;22)(q22;q13) and Dermatofibrosarcoma Protuberans
PTCH ( PTC ) 9q22.3 -PTCH and Nevoid Basal Cell Carcinoma Syndrome
PTGS2 ( COX2 ) 1q25.2-q25.3 -PTGS2 Overexpression in Skin Cancer
SMOH ( SMO ) 7q31-q32 -SMOH and Basal Cell Carcinoma

 

  Recurrent Chromosome Abnormalities

t(17;22)(q22;q13) and Dermatofibrosarcoma Protuberans
  Genetics of Basal Cell Carcinoma

  • Booth DR The hedgehog signalling pathway and its role in basal cell carcinoma. Cancer Metastasis Rev 1999;18(2):261-84    Related articles (PubMed)

  • Requena L, et al. Multiple hereditary infundibulocystic basal cell carcinomas: a genodermatosis different from nevoid basal cell carcinoma syndrome. Arch Dermatol 1999 Oct;135(10):1227-35    Related articles (PubMed)

  • Cohen MM Jr Nevoid basal cell carcinoma syndrome: molecular biology and new hypotheses. Int J Oral Maxillofac Surg 1999 Jun;28(3):216-23    Related articles (PubMed)

     

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