 Summary Information
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Location: 17q12
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| Gene Database Entries for RARA
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OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for RARA)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND RARA[TI] (PubMed)
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| RARA and Acute Promyelocytic Leukaemia
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Chen Z, et al. Retinoic acid regulatory pathways, chromosomal translocations, and acute promyelocytic leukemia. Genes Chromosomes Cancer 1996;15(3):147-56 Related articles (PubMed)
Medline Search: RARA AND acute promyelocytic leukaemia (PubMed)
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Medline Search: acute promyelocytic leukaemia (PubMed)
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- Related Resources
 Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| t(15;17)(q21;q21) RARA-PML translocation in APL
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Grignani F, et al. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature 1998;391(6669):815-8 Related articles (PubMed)
Alcalay M, et al. Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia. Proc Natl Acad Sci USA 1992; 89(11):4840-4 Related articles (PubMed)
de The H, et al. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature 1990; 347(6293):558-61 Related articles (PubMed)
He LZ, et al. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nat Genet 1998;18(2):126-35 Related articles (PubMed)
Medline Search: RARA AND PML AND acute promyelocytic leukaemia (PubMed)
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Medline Search: acute promyelocytic leukaemia (PubMed)
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- RARA gene
- PML gene
Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| t(11;17)(q32;q21) RARA-PLZF translocation in APL
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He LZ, et al. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nat Genet 1998;18(2):126-35 Related articles (PubMed)
Koken MH, et al. Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. Oncogene. 1999; 18(4):1113-8 Related articles (PubMed)
Medline Search: chromosome 11 and chromosome 17 and translocation AND acute promyelocytic leukaemia (PubMed)
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- PLZF gene
Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| t(5;17)(q32;q11) RARA-NPM translocation in APL
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Redner RL, et al. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood. 1996; 87(3):882-6 Related articles (PubMed)
Medline Search: chromosome 5 and chromosome 17 and translocation AND acute promyelocytic leukaemia (PubMed)
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- RARA gene
- NPM1 gene
Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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[Home] This page created: 02/11/1999 Last revised: 29/04/2003 © Copyright 1999-
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