 Summary Information
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Location: 5q31.3-q32
Aliases: ON, OSN
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| Gene Database Entries for SPARC
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OMIM
GeneCard (Weizmann Institute)
Genbank
Swiss-Prot
Locus Link (search for SPARC)
UniGene
GenAtlas
GDB
Nomenclature (search for SPARC)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (SPARC[TI] OR ON[TI] OR OSN[TI]) (PubMed)
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| SPARC and Cancer
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Motamed K SPARC (osteonectin/BM-40) [Review] Int J Biochem Cell Biol 1999 Dec;31(12):1363-6 Related articles (PubMed)
Porter PL, et al. Distribution of SPARC in normal and neoplastic human tissue. J Histochem Cytochem 1995 Aug;43(8):791-800 Related articles (PubMed)
Medline Search: cancer AND (sparc OR osteonectin) (PubMed)
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| SPARC Expression in Ovarian Carcinoma
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Brown TJ, et al. Activation of SPARC expression in reactive stroma associated with human epithelial ovarian cancer. Gynecol Oncol 1999 Oct;75(1):25-33 Related articles (PubMed)
Mok SC, et al. SPARC, an extracellular matrix protein with tumor-suppressing activity in human ovarian epithelial cells. Oncogene 1996 May 2;12(9):1895-901 Related articles (PubMed)
Medline Search: ovarian cancer AND (sparc OR osteonectin) (PubMed)
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 Ovarian Ca. Genetics
Ovarian Ca. : Clinical and Epidemiological Information
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| SPARC Expression and Prostate Cancer
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Thomas R, et al. Differential expression of osteonectin/SPARC during human prostate cancer progression. Clin Cancer Res 2000 Mar;6(3):1140-9 Related articles (PubMed)
Jacob K, et al. Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone. Cancer Res 1999 Sep 1;59(17):4453-7 Related articles (PubMed)
Medline Search: prostate cancer AND (sparc OR osteonectin) (PubMed)
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Prostate Cancer Genetics
Prostate Cancer : Clinical and Epidemiological Information
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| SPARC Over-expression in Hepatocellular Carcinoma
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Le Bail B, et al. Osteonectin/SPARC is overexpressed in human hepatocellular carcinoma J Pathol 1999 Sep;189(1):46-52 Related articles (PubMed)
Medline Search: hepatocellular carcinoma AND (sparc OR osteonectin) (PubMed)
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Hepatocelular Carcinoma Genetics
Hepatocelular Carcinoma : Clinical and Epidemiological Information
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| SPARC Expression in CNS Tumours
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Golembieski WA, et al. Increased SPARC expression promotes U87 glioblastoma invasion in vitro. Int J Dev Neurosci 1999 Aug-Oct;17(5-6):463-72 Related articles (PubMed)
Vajkoczy P, et al. Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC. Int J Cancer 2000 Jul 15;87(2):261-8 Related articles (PubMed)
Rempel SA, et al. SPARC: a potential diagnostic marker of invasive meningiomas. Clin Cancer Res 1999 Feb;5(2):237-41 Related articles (PubMed)
Rempel SA, et al. SPARC: a signal of astrocytic neoplastic transformation and reactive response in human primary and xenograft gliomas. J Neuropathol Exp Neurol 1998 Dec;57(12):1112-21 Related articles (PubMed)
Medline Search: brain tumor AND (sparc OR osteonectin) (PubMed)
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| SPARC Expression in Melanoma
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Massi D, et al. Osteonectin expression correlates with clinical outcome in thin cutaneous malignant melanomas. Hum Pathol 1999 Mar;30(3):339-44 Related articles (PubMed)
Medline Search: melanoma AND (sparc OR osteonectin) (PubMed)
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| SPARC Expression in Esophageal Cancer
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Porte H, et al. Overexpression of stromelysin-3, BM-40/SPARC, and MET genes in human esophageal carcinoma: implications for prognosis. Clin Cancer Res 1998 Jun;4(6):1375-82 Related articles (PubMed)
Medline Search: esophageal cancer AND (sparc OR osteonectin) (PubMed)
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Esophageal Cancer Genetics
Esophageal Cancer : Clinical and Epidemiological Information
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[Home] This page created: 01/05/2000 Last revised: 29/04/2003 © Copyright 1999-
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