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  Childhood Brain Tumours

Mutated Genes and Abnormal Protein Expression (11)
Recurrent Chromosome Abnormalities (3)
Overview of Childhood CNS Tumour Genetics
Loss of 17p Material in Childhood CNS tumours
Isochromosome 17q in Medulloblastoma
Loss of 22q Material in Childhood CNS tumours
  Mutated Genes and Abnormal Protein Expression
GeneLocationTopics
SLC2A1 ( GLUT1 ) 1p35-p31.3 -GLUT1 Expression in Embryonal CNS Tumours
ERBB42q34 -ERBB4 and Childhood Medulloblastoma
VIPR1 ( RCD1 , HVR1 ) 3p22 -VIPR1 Expression in Childhood PNET
VIPR27q36.3 -VIPR2 Expression in Childhood PNET
MYC ( CMYC , C-MYC ) 8q24.12-q24.13 -MYC and Medulloblastoma
PTCH ( PTC ) 9q22.3 -PTCH and Medulloblastoma
PTEN ( MMAC1 , MHAM , BZS ) 10q23.3 -PTEN and astrocytoma
NEURL ( H-NEU ) 10q25.1  
NTRK3 ( TRKC ) 15q25 -NTRK3 and Medulloblastoma
NF117q11.2 -Childhood Glioma and NF1
ERBB2 ( HER2 , NEU ) 17q11.2-q12 -ERBB2 and Childhood Medulloblastoma

 

  Recurrent Chromosome Abnormalities

Loss of 17p Material in Childhood CNS tumours
Isochromosome 17q in Medulloblastoma
Loss of 22q Material in Childhood CNS tumours
  Overview of Childhood CNS Tumour Genetics

  • Biegel JA.et al. Genetics of pediatric central nervous system tumours J Pediatr Hematol Oncol. 1997;19(6):492-501. [Review]    Related articles (PubMed)

  • Cheng Y, et al. Genetic alterations in pediatric high-grade astrocytomas. Hum Pathol 1999;30(11):1284-90    Related articles (PubMed)

  • Pomeroy SL. The p53 tumor suppressor gene and pediatric brain tumors. [Review] Curr Opin Pediatr. 1994;6(6):632-5    Related articles (PubMed)

  • Medline Search: childhood AND brain tumor AND genetics AND review[PT] (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Childhood Brain Tumours Genetics

     

  •   Loss of 17p Material in Childhood CNS tumours

  • von Haken MS,et al. Molecular genetic analysis of chromosome arm 17p and chromosome arm 22q DNA sequences in sporadic pediatric ependymomas Genes Chromosomes Cancer 1996; 17(1):37-44    Related articles (PubMed)

  • Willert JR, et al. Deletion of chromosome arm 17p DNA sequences in pediatric high-grade and juvenile pilocytic astrocytomas. Genes Chromosomes Cancer. 1995; 12(3):165-72    Related articles (PubMed)

  • Burnett ME, et al. Chromosome arm 17p deletion analysis reveals molecular genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumors of the central nervous system Cancer Genet Cytogenet. 1997;97(1):25-31    Related articles (PubMed)

  • Medline Search: 17p AND childhood AND brain tumor (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Childhood Brain Tumours Genetics
    Chromosme 17

     

  •   Isochromosome 17q in Medulloblastoma

  • Giordana MT, et al. Isochromosome 17q is a constant finding in medulloblastoma. An interphase cytogenetic study on tissue sections Neuropathol Appl Neurobiol. 1998; 24(3):233-8    Related articles (PubMed)

  • Biegel JA, et al. Isochromosome 17q in primitive neuroectodermal tumors of the central nervous system Genes Chromosomes Cancer. 1989; 1(2):139-47    Related articles (PubMed)

  • Medline Search: medulloblastoma AND (isochromosome 17q OR chromosome 17) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Childhood Brain Tumours Genetics
    Chromosme 17

     

  •   Loss of 22q Material in Childhood CNS tumours

  • von Haken MS,et al. Molecular genetic analysis of chromosome arm 17p and chromosome arm 22q DNA sequences in sporadic pediatric ependymomas Genes Chromosomes Cancer 1996; 17(1):37-44    Related articles (PubMed)

  • Ebert C, et al. Molecular genetic analysis of ependymal tumors. NF2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas Am J Pathol. 1999; 155(2):627-32    Related articles (PubMed)

  • Akagi K, et al. Deletion mapping of the long arm of chromosome 22 in human meningiomas. Int J Cancer. 1995; 60(2):178-82    Related articles (PubMed)

  • Medline Search: childhood AND brain tumor AND (22q OR chromosome 22) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Childhood Brain Tumours Genetics
    Chromosme 22

     

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