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PDGFB; Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) (22q12.3-q13.1)
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    Summary Information - PDGFB
    Gene Database Entries for PDGFB
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    t(17;22)(q22;q13) and Dermatofibrosarcoma Protuberans
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  Summary Information

PDGFB; Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

Location: 22q12.3-q13.1
Alias: SIS

Implicated in meningioma and Dermatofibrosarcoma protuberans

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  Gene Database Entries for PDGFB

OMIM
GeneCard (Weizmann Institute)
Genbank
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Locus Link
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Nomenclature (search for PDGFB)

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  Other Related Resources

Search Medline for related articles (PubMed)
  • Medline Search: cancer AND gene AND (PDGFB[TI] OR SIS[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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      t(17;22)(q22;q13) and Dermatofibrosarcoma Protuberans

  • Wang J, et al. Detection of COL1A1-PDGFB fusion transcripts in dermatofibrosarcoma protuberans by reverse transcription-polymerase chain reaction using archival formalin-fixed, paraffin-embedded tissues. Diagn Mol Pathol 1999 Sep;8(3):113-9    Related articles (PubMed)

  • O'Brien KP, et al. Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas. Genes Chromosomes Cancer. 1998;23(2):187-93.    Related articles (PubMed)

  • Greco A, et al. Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans. Oncogene. 1998 Sep 10;17(10):1313-9.    Related articles (PubMed)

  • Simon MP, et al. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat Genet 1997;15(1):95-8    Related articles (PubMed)

  • Heller S, et al. PDGF B mRNA variants in human tumors with similarity to the v-sis oncogene: expression of cellular PDGF B protein is associated with exon 1 divergence, but not with a 3'UTR splice variant. Int J Cancer 2000 Jan 15;85(2):211-22    Related articles (PubMed)

  • Medline Search: dermatofibrosarcoma protuberans AND ( t(17;22) OR PDGFB OR COL1A1) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources

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