|Gene:||MIR1258; microRNA 1258|
|Aliases:||MIRN1258, mir-1258, hsa-mir-1258|
|Summary:||microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]|
|Databases:||miRBase, OMIM, HGNC, Ensembl, GeneCard, Gene|
|Source:||NCBIAccessed: 06 August, 2015|
Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.
Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Lung Cancer||MicroRNA miR-1258 and Lung Cancer||View Publications||2|
|Breast Cancer||MicroRNA miR-1258 and Breast Cancer||View Publications||2|
|Lung Cancer, Non-Small Cell||MicroRNA miR-1258 and Non-Small Cell Lung Cancer||View Publications||2|
|Brain Tumours, Childhood||MicroRNA miR-1258 and Brain Tumours||View Publications||1|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs.
|Tissue||Target Gene(s)||Regulator(s)||MIR1258 Function in Cancer||Effect|
-non-small cell lung cancer (1)
|inhibit cell invasion (1)||tumor-suppressive
-breast cancer (1)
|HPSE (1)||inhibit cell invasion (1)|
reduce brain metastasis (1)
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Cite this page: Cotterill SJ. MicroRNA miR-1258, Cancer Genetics Web: http://www.cancer-genetics.org/MIR1258.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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