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  Chromosome 2

Genes Linked with Cancer (126)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 2; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
TCF7L1 2p11.2 TCF3, TCF-3-Acute Lymphocytic Leukaemia (ALL)
IGK 2p12 IGK@Somatic-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Childhood Cancers
-Multiple Myeloma
REG1A 2p12 P19, PSP, PTP, REG, ICRF, PSPS, PSPS1-Colorectal Cancer
-Esophageal Cancer
-Pancreatic Cancer
-Stomach Cancer
TGFA 2p13 TFGA-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
-Neuroblastoma
-Vulvar Cancer
TIA1 2p13 WDM, TIA-1-Cutaneous T-cell lymphoma
-Hodgkin Lymphoma
-Paranasal Sinus and Nasal Cavity Cancer
MXD1 2p13-p12 MAD, MAD1, BHLHC58
REL 2p13-p12 C-RelSomatic-Breast Cancer
-Hodgkin Lymphoma
NOTO 2p13.2 -Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
MEIS1 2p14 -Acute Myeloid Leukaemia
-Leukaemia
XPO1 2p15 emb, CRM1, exp1Somatic-Chronic Lymphocytic Leukemia
-Chronic Myelogenous Leukemia
MSH6 2p16 GTBP, HSAP, p160, GTMBP, HNPCC5Germline & Somatic-Colorectal Cancer
-Endometrial Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Ovarian Cancer
-Urethral Cancer
EFEMP1 2p16 DHRD, DRAD, FBNL, MLVT, MTLV, S1-5, FBLN3, FIBL-3-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
FANCL 2p16.1 POG, PHF9, FAAP43Germline-Fanconi Anaemia
BCL11A 2p16.1 EVI9, CTIP1, ZNF856, HBFQTL5, BCL11A-L, BCL11A-S, BCL11a-M, BCL11A-XLSomatic-Childhood Cancers
-Chronic Lymphocytic Leukemia
-Hodgkin Lymphoma
FBXO11 2p16.3 UBR6, VIT1, FBX11, PRMT9, UG063H01Somatic-Pancreatic Cancer
EPCAM 2p21 ESA, KSA, M4S1, MK-1, DIAR5, EGP-2, EGP40, KS1/4, MIC18, TROP1, EGP314, HNPCC8, TACSTD1-Breast Cancer
-Colorectal Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Liver Cancer
-Lung Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Stomach Cancer
MSH2 2p21 FCC1, COCA1, HNPCC, LCFS2, HNPCC1Germline & Somatic-Colorectal Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Ovarian Cancer
-Rectal Cancer
-Stomach Cancer
EPAS1 2p21-p16 HLF, MOP2, ECYT4, HIF2A, PASD2, bHLHe73-Adrenocortical Cancer
-Kidney Cancer
-Neuroblastoma
-Pheochromocytoma and Paraganglioma
EML4 2p21 C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120Somatic-Bladder Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
FSHR 2p21-p16 LGR1, ODG1, FSHRO-Ovarian Cancer
-Testicular Cancer
SOS1 2p21 GF1, HGF, NS4, GGF1, GINGF-Haematological Malignancies
-Lung Cancer
GALM 2p22.1 GLAT, IBD1, BLOCK25, HEL-S-63p-Acute Myeloid Leukaemia
-Breast Cancer
-Haematological Malignancies
-Multiple Myeloma
-Myelodysplastic Syndromes
CYP1B1 2p22.2 CP1B, GLC3A, CYPIB1, P4501B1-Breast Cancer
-Endometrial Cancer
-Lung Cancer
-Stomach Cancer
-Testicular Cancer
DNMT3A 2p23 TBRS, DNMT3A2, M.HsaIIIASomatic-Acute Myeloid Leukaemia
-Breast Cancer
-Childhood Cancers
-Myelodysplastic Syndromes
-Ovarian Cancer
NCOA1 2p23 SRC1, KAT13A, RIP160, F-SRC-1, bHLHe42, bHLHe74Somatic-Breast Cancer
-Prostate Cancer
SRD5A2 2p23 -Breast Cancer
-Prostate Cancer
ALK 2p23 CD246, NBLST3Germline & Somatic
Translocation
-Familial Neuroblastoma
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Neuroblastoma
-Non-Hodgkin Lymphoma
FOSL2 2p23.3 FRA2
POMC 2p23.3 LPH, MSH, NPP, POC, ACTH, CLIP-Lung Cancer
-Pituitary Tumors
-Skin Cancer
C2orf44 2p23.3 PP384Somatic-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
RHOB 2p24 ARH6, ARHB, RHOH6, MST081, MSTP081-Breast Cancer
-Lung Cancer
-Pancreatic Cancer
ROCK2 2p24 ROCK-II-Breast Cancer
-Lung Cancer
-Prostate Cancer
APOB 2p24-p23 FLDB, LDLCQ4-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Uterine Sarcoma
DDX1 2p24 DBP-RB, UKVH5d
Amplification
-Neuroblastoma
-Retinoblastoma
SDC1 2p24.1 SDC, CD138, SYND1, syndecan-Breast Cancer
-Multiple Myeloma
MYCN 2p24.3 NMYC, ODED, MODED, N-myc, bHLHe37Somatic
Amplification
Overexpression
Many cancer types including:
-Breast Cancer
-Lung Cancer
-Neuroblastoma
-Osteosarcoma
-Retinoblastoma
-Rhabdomyosarcoma
-Wilms Tumour
ID2 2p25 GIG8, ID2A, ID2H, bHLHb26OverexpressionMany cancer types including:
-Breast Cancer
-Ewing's Sarcoma
-Leukaemia
-Liver Cancer
-Lung Cancer
-Neuroblastoma
-Pancreatic Cancer
RRM2 2p25-p24 R2, RR2, RR2M-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
SOX11 2p25 MRD27-Cervical Cancer
-Mantle-Cell Lymphoma
-Prostate Cancer
TPO 2p25 MSA, TPX, TDH2A-Thyroid Cancer
ADAM17 2p25 CSVP, TACE, NISBD, ADAM18, CD156B, NISBD1-Brain Stem Glioma, Childhood
-Breast Cancer
-Head and Neck Cancers
-Prostate Cancer
-Uterine Sarcoma
ODC1 2p25 ODC-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Neuroblastoma
-Prostate Cancer
-Rectal Cancer
-Skin Cancer
-Stomach Cancer
TMEM127 2q11.2 -Adrenocortical Cancer
-Head and Neck Cancers
-Pheochromocytoma and Paraganglioma
-von Hippel-Lindau Disease
AFF3 2q11.2-q12 LAF4, MLLT2-likeSomatic-Acute Lymphocytic Leukaemia (ALL)
-Stomach Cancer
IL1RL1 2q12 T1, ST2, DER4, ST2L, ST2V, FIT-1, IL33R-Acute Myeloid Leukaemia
-Brain Tumours, Childhood
-Breast Cancer
-Pancreatic Cancer
ZAP70 2q12 SRK, STD, TZK, STCD, ZAP-70-Chronic Lymphocytic Leukemia
C2orf40 2q12.2 ECRG4-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
FHL2 2q12.2 DRAL, AAG11, FHL-2, SLIM3, SLIM-3-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
RANBP2 2q12.3 ANE1, TRP1, TRP2, ADANE, IIAE3, NUP358-Colorectal Cancer
-Soft Tissue Sarcoma
PAX8 2q13 Somatic
Translocation
-Kidney Cancer
-Thyroid Cancer
PROC 2q13-q14 PC, APC, PROC1, THPH3, THPH4-Breast Cancer
-Lung Cancer
BCL2L11 2q13 BAM, BIM, BOD-Acute Lymphocytic Leukaemia (ALL)
-Colorectal Cancer
-Lung Cancer
-Non-Hodgkin Lymphoma
-Stomach Cancer
MALL 2q13 BENE-Breast Cancer
-Oral Cavity Cancer
TTL 2q13 Somatic-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Lung Cancer
IL1A 2q14 IL1, IL-1A, IL1F1, IL1-ALPHA-Breast Cancer
-Cervical Cancer
-Kaposi Sarcoma
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Stomach Cancer
-Thyroid Cancer
GLI2 2q14 HPE9, PHS2, THP1, THP2-Bladder Cancer
-Childhood Cancers
-Basal Cell Carcinoma (BCC) - Skin
BIN1 2q14 AMPH2, AMPHL, SH3P9-Breast Cancer
-Melanoma
-Neuroblastoma
-Prostate Cancer
BUB1 2q14 BUB1A, BUB1L, hBUB1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Salivary Gland Cancer
-Stomach Cancer
-Thyroid Cancer
-Wilms Tumour
IL1B 2q14 IL-1, IL1F2, IL1-BETA-Breast Cancer
-Cervical Cancer
-Kaposi Sarcoma
-Lung Cancer
-Prostate Cancer
MERTK 2q14.1 MER, RP38, c-Eyk, c-mer, Tyro12-Acute Myeloid Leukaemia
-Brain Tumours, Childhood
-Liver Cancer
IL1RN 2q14.2 DIRA, IRAP, IL1F3, IL1RA, MVCD4, IL-1RN, IL-1ra, IL-1ra3, ICIL-1RA-Cervical Cancer
-Stomach Cancer
-Vulvar Cancer
MARCO 2q14.2 SCARA2-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Oral Cavity Cancer
-Pancreatic Cancer
RALB 2q14.2 -Bladder Cancer
-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
CXCR4 2q21 FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LAP-3, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E-Breast Cancer
-Eye Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
ERCC3 2q21 XPB, BTF2, GTF2H, RAD25, TFIIHGermline-Childhood Cancers
-Skin Cancer
LRP1B 2q21.2 LRPDIT, LRP-DIT-Breast Cancer
-Lung Cancer
NR4A2 2q22-q23 NOT, RNR1, HZF-3, NURR1, TINUR-Adrenocortical Cancer
-Cervical Cancer
-Colorectal Cancer
ZEB2 2q22.3 SIP1, SIP-1, ZFHX1B, HSPC082, SMADIP1-Breast Cancer
-Kidney Cancer
-Liver Cancer
-Lung Cancer
-Stomach Cancer
ACVR1 2q23-q24 FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2-Astrocytoma, Childhood
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Colorectal Cancer
-Ovarian Cancer
TANK 2q24-q31 ITRAF, TRAF2, I-TRAF-Bladder Cancer
-Breast Cancer
-Lung Cancer
NFE2L2 2q31 NRF2Somatic-Breast Cancer
-Esophageal Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
HOXD10 2q31.1 HOX4, HOX4D, HOX4E, Hox-4.4-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
-Wilms Tumour
CHN1 2q31.1 NC, CHN, DURS2, ARHGAP2, RHOGAP2Somatic
HOXD13 2q31.1 BDE, SPD, BDSD, HOX4ISomatic-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
HOXD11 2q31.1 HOX4, HOX4FSomatic-Melanoma
-Neuroblastoma
-Stomach Cancer
PDK1 2q31.1 -Breast Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
-Thyroid Cancer
PMS1 2q31.1 PMSL1, hPMS1, HNPCC3Germline-Colorectal Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Skin Cancer
-Urinary System Cancers
PDE11A 2q31.2 PPNAD2-Adrenocortical Cancer
-Germ Cell Tumours
-Pituitary Tumors
-Prostate Cancer
-Testicular Cancer
ITGA4 2q31.3 IA4, CD49D-Bladder Cancer
-Breast Cancer
-Chronic Lymphocytic Leukemia
-Melanoma
-Multiple Myeloma
-Stomach Cancer
ATF2 2q32 HB16, CREB2, TREB7, CREB-2, CRE-BP1-Breast Cancer
-Liver Cancer
-Melanoma
-Prostate Cancer
TFPI 2q32 EPI, TFI, LACI, TFPI1-Brain Tumours, Childhood
-Breast Cancer
-Cervical Cancer
-Eye Cancer
-Lung Cancer
-Pancreatic Cancer
NEUROD1 2q32 BETA2, BHF-1, MODY6, NEUROD, bHLHa3-Lung Cancer
-Pancreatic Cancer
-Pituitary Tumors
FRZB 2q32.1 FRE, OS1, FZRB, hFIZ, FRITZ, FRP-3, FRZB1, SFRP3, SRFP3, FRZB-1, FRZB-PEN-Breast Cancer
-Colorectal Cancer
-Multiple Myeloma
STAT1 2q32.2 CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91-Breast Cancer
-Melanoma
STAT4 2q32.2-q32.3 SLEB11-Liver Cancer
-Skin Cancer
TMEFF2 2q32.3 TR, HPP1, TPEF, TENB2, CT120.2-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Prostate Cancer
CD28 2q33 Tp44-Skin Cancer
ABI2 2q33 ABI-2, ABI2B, AIP-1, AblBP3, argBP1, SSH3BP2, argBPIA, argBPIB-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Leukaemia
CASP8 2q33-q34 CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8
Methylation
-Breast Cancer
-Cervical Cancer
-Neuroblastoma
BOLL 2q33 BOULE-Acute Myeloid Leukaemia
-Breast Cancer
-Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Leukaemia
-Lung Cancer
-Uterine Sarcoma
CTLA4 2q33 CD, GSE, GRD4, ALPS5, CD152, CTLA-4, IDDM12, CELIAC3-Breast Cancer
-Melanoma
CFLAR 2q33-q34 CASH, FLIP, MRIT, CLARP, FLAME, Casper, FLAME1, c-FLIP, FLAME-1, I-FLICE, c-FLIPL, c-FLIPR, c-FLIPS, CASP8AP1-Oral Cavity Cancer
-Stomach Cancer
BMPR2 2q33-q34 BMR2, PPH1, BMPR3, BRK-3, POVD1, T-ALK, BMPR-II-Bladder Cancer
-Breast Cancer
-Prostate Cancer
CASP10 2q33-q34 MCH4, ALPS2, FLICE2-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Stomach Cancer
ICOS 2q33 AILIM, CD278, CVID1-Cervical Cancer
-Melanoma
-Skin Cancer
-Vulvar Cancer
FZD7 2q33 FzE3-Colorectal Cancer
-Stomach Cancer
SF3B1 2q33.1 MDS, PRP10, Hsh155, PRPF10, SAP155, SF3b155Somatic-Acute Myeloid Leukaemia
-Chronic Lymphocytic Leukemia
-Melanoma
-Myelodysplastic Syndromes
FTCDNL1 2q33.1 FONG-Breast Cancer
-Cervical Cancer
-Chondrosarcoma
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Thyroid Cancer
NRP2 2q33.3 NP2, NPN2, PRO2714, VEGF165R2-Bladder Cancer
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Lung Cancer
-Lung Cancer, Non-Small Cell
IDH1 2q33.3 IDH, IDP, IDCD, IDPC, PICD, HEL-216, HEL-S-26Somatic-Acute Myeloid Leukaemia
-Astrocytoma, Childhood
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Childhood Cancers
ERBB4 2q33.3-q34 HER4, ALS19, p180erbB4-Medulloblastoma
-Breast Cancer
-Lung Cancer
-Melanoma
-Prostate Cancer
BARD1 2q34-q35 -Breast Cancer
-Cervical Cancer
-Neuroblastoma
-Ovarian Cancer
-Uterine Sarcoma
ACSL3 2q34-q35 ACS3, FACL3, PRO2194Somatic-Breast Cancer
-Prostate Cancer
CREB1 2q34 CREBSomatic-Breast Cancer
-Childhood Cancers
-Lung Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
MAP2 2q34-q35 MAP2A, MAP2B, MAP2C-Brain Tumours, Childhood
-Melanoma
PAX3 2q35 WS1, WS3, CDHS, HUP2Somatic
Translocation
-Childhood Cancers
-Melanoma
-Rhabdomyosarcoma
-Soft Tissue Sarcoma
-Urinary System Cancers
ATIC 2q35 PURH, AICAR, AICARFT, IMPCHASE, HEL-S-70pSomatic-Bladder Cancer
-Childhood Cancers
-Hodgkin Lymphoma
-Lung Cancer
-Non-Hodgkin Lymphoma
IGFBP2 2q35 IBP2, IGF-BP53-Astrocytoma, Childhood
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
-Skin Cancer
CXCR1 2q35 C-C, CD128, CD181, CKR-1, IL8R1, IL8RA, CMKAR1, IL8RBA, CDw128a, C-C-CKR-1-Breast Cancer
-Lung Cancer
-Prostate Cancer
-Uterine Sarcoma
INHA 2q35 -Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
-Stomach Cancer
XRCC5 2q35 KU80, KUB2, Ku86, NFIV, KARP1, KARP-1-Bladder Cancer
-Leukaemia
-Lung Cancer
-Stomach Cancer
CXCR2 2q35 CD182, IL8R2, IL8RA, IL8RB, CMKAR2, CDw128b-Breast Cancer
-Colorectal Cancer
-Pancreatic Cancer
-Prostate Cancer
IGFBP5 2q35 IBP5-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Prostate Cancer
-Salivary Gland Cancer
-Thyroid Cancer
IRS1 2q36 HIRS-1-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
FEV 2q36 PET-1, HSRNAFEVSomatic
Translocation
-Bone Cancer (primary)
-Childhood Cancers
-Ewing's Sarcoma
-Lung Cancer
SLC4A3 2q36 AE3, SLC2C-Colorectal Cancer
CUL3 2q36.2 CUL-3, PHA2E-Bladder Cancer
-Breast Cancer
CCL20 2q36.3 CKb4, LARC, ST38, MIP3A, Exodus, MIP-3a, SCYA20, MIP-3-alpha-Colorectal Cancer
-Lung Cancer
UGT1A1 2q37 GNT1, UGT1, UDPGT, UGT1A, HUG-BR1, BILIQTL1, UDPGT 1-1-Colorectal Cancer
-Small Cell Lung Cancer
-Prostate Cancer
-Stomach Cancer
-Urinary System Cancers
TRPM8 2q37.1 TRPP8, LTRPC6-Eye Cancer
-Melanoma
-Prostate Cancer
ING5 2q37.3 p28ING5-Colorectal Cancer
-Oral Cavity Cancer
TWIST2 2q37.3 FFDD3, DERMO1, SETLSS, bHLHa39-Cervical Cancer
-Ovarian Cancer
PER2 2q37.3 FASPS, FASPS1-Breast Cancer
-Colorectal Cancer
HDAC4 2q37.3 HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A-Bladder Cancer
-Breast Cancer
-Ovarian Cancer
-Stomach Cancer
-Thyroid Cancer
-Waldenstrom's Macroglobulinemia
ACKR3 2q37.3 RDC1, CXCR7, RDC-1, CMKOR1, CXC-R7, CXCR-7, GPR159Somatic-Acute Lymphocytic Leukaemia (ALL)
PDCD1 2q37.3 PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1-Cervical Cancer
-Melanoma
-Skin Cancer
-Stomach Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 2:

Abnormality Type Gene(s)
ALK-CTCL Rearrangements in diffuse large B-cell lymphomaALK (2p23)TSPYL2 (Xp11.2)
ALK-EML4 Rearrangements in NSCLCALK (2p23)EML4 (2p21)
ALK-RANBP2 Rearrangements in Inflammatory Myofibroblastic TumorALK (2p23)RANBP2 (2q12.3)
ATIC-ALK Rearrangements in anaplastic large cell lymphomaALK (2p23)ATIC (2q35)
KIF5B-ALK Rearrangements in Lung CancerKIF5B (10p11.22)
t(2;22) EWSR1-FEV Translocation in Ewing's SarcomaTranslocationFEV (2q36)EWSR1 (22q12.2)
t(2;5)(p23;q35) NPM1-ALK translocation in Anaplastic large cell lymphomaTranslocationALK (2p23)NPM1 (5q35.1)
t(2;13)(q35;q14) in RhabdomyosarcomaTranslocationPAX3 (2q35)FOXO1 (13q14.1)
PAX8-PPARG fusion in Folicular Thyroid CancerTranslocationPAX8 (2q13)PPARG (3p25)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

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Cite this page: Cotterill SJ. Chromosome 2, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc02.htm Accessed: date

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