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  Chromosome 2

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 2; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
EPCAM None
IGK 2p12 IGK@Somatic
REG1A 2p12 P19, PSP, PTP, REG, ICRF, PSPS, PSPS1
REL 2p13-p12 C-RelSomatic
TGFA 2p13 TFGA
XPO1 2p15 emb, CRM1, exp1Somatic
MSH6 2p16 GTBP, HSAP, p160, GTMBP, HNPCC5Germline & Somatic
FANCL 2p16.1 POG, PHF9, FAAP43Germline-Fanconi Anaemia
BCL11A 2p16.1 EVI9, CTIP1, ZNF856, HBFQTL5, BCL11A-L, BCL11A-S, BCL11a-M, BCL11A-XLSomatic
FBXO11 2p16.3 UBR6, VIT1, FBX11, PRMT9, UG063H01Somatic
MSH2 2p21 FCC1, COCA1, HNPCC, LCFS2, HNPCC1Germline & Somatic
EML4 2p21 C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120Somatic
CYP1B1 2p22.2 CP1B, GLC3A, CYPIB1, P4501B1
SRD5A2 2p23
ALK 2p23 CD246, NBLST3Germline & Somatic
Translocation
-Non-Hodgkin Lymphoma
NCOA1 2p23 SRC1, KAT13A, RIP160, F-SRC-1, bHLHe42, bHLHe74Somatic
DNMT3A 2p23 DNMT3A2, M.HsaIIIASomatic
FOSL2 2p23.3 FRA2
C2orf44 2p23.3 PP384Somatic
DDX1 2p24 DBP-RB, UKVH5d
RHOB 2p24 ARH6, ARHB, RHOH6, MST081, MSTP081-Breast Cancer
-Lung Cancer
-Pancreatic Cancer
SDC1 2p24.1 SDC, CD138, SYND1, syndecan
MYCN 2p24.3 NMYC, ODED, MODED, N-myc, MYCNOT, bHLHe37Somatic
Amplification
Overexpression
Many cancer types including:
-Breast Cancer
-Lung Cancer
-Neuroblastoma
-Osteosarcoma
-Retinoblastoma
-Wilms Tumour
ODC1 2p25 ODC
TPO 2p25 MSA, TPX, TDH2A
ID2 2p25 GIG8, ID2A, ID2H, bHLHb26OverexpressionMany cancer types including:
-Breast Cancer
-Ewing's Sarcoma
-Leukaemia
-Liver Cancer
-Lung Cancer
-Neuroblastoma
-Pancreatic Cancer
AFF3 2q11.2-q12 LAF4, MLLT2-likeSomatic
PAX8 2q13 Somatic
TTL 2q13 Somatic
GLI2 2q14 HPE9, THP1, THP2
RALB 2q14.2
ERCC3 2q21 XPB, BTF2, GTF2H, RAD25, TFIIHGermline
NFE2L2 2q31 NRF2Somatic
HOXD13 2q31.1 BDE, SPD, BDSD, HOX4ISomatic
PMS1 2q31.1 PMSL1, hPMS1, HNPCC3Germline
CHN1 2q31.1 NC, CHN, DURS2, ARHGAP2, RHOGAP2Somatic
HOXD11 2q31.1 HOX4, HOX4FSomatic
CASP8 2q33-q34 CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8
Methylation
-Neuroblastoma
SF3B1 2q33.1 MDS, PRP10, Hsh155, PRPF10, SAP155, SF3b155Somatic
IDH1 2q33.3 IDH, IDP, IDCD, IDPC, PICD, HEL-S-26Somatic
ERBB4 2q33.3-q34 HER4, ALS19, p180erbB4
ACSL3 2q34-q35 ACS3, FACL3, PRO2194Somatic
BARD1 2q34-q35 -Breast Cancer
-Cervical Cancer
-Neuroblastoma
-Ovarian Cancer
-Uterine Sarcoma
CREB1 2q34 CREBSomatic
PAX3 2q35 WS1, WS3, CDHS, HUP2Somatic
Translocation
-Rhabdomyosarcoma
ATIC 2q35 PURH, AICAR, AICARFT, IMPCHASE, HEL-S-70pSomatic
FEV 2q36 PET-1, HSRNAFEVSomatic
Translocation
-Ewing's Sarcoma
ACKR3 2q37.3 RDC1, CXCR7, RDC-1, CMKOR1, CXC-R7, CXCR-7, GPR159Somatic
PDCD1 2q37.3 PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 2:

Abnormality Type Gene(s)
t(2;22) EWSR1-FEV Translocation in Ewing's SarcomaTranslocationFEV (2q36)EWSR1 (22q12.2)
t(2;5)(p23;q35) NPM1-ALK translocation in Anaplastic large cell lymphomaTranslocationALK (2p23)NPM1 (5q35.1)
t(2;13)(q35;q14) in RhabdomyosarcomaTranslocationPAX3 (2q35)FOXO1 (13q14.1)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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