C2orf44

Gene Summary

Gene:C2orf44; chromosome 2 open reading frame 44
Aliases: WDCP, PP384
Location:2p23.3
Summary:-
Databases:OMIM, VEGA, HGNC, Ensembl, GeneCard, Gene
Protein:WD repeat and coiled-coil-containing protein C2orf44
HPRD
Source:NCBIAccessed: 17 August, 2015

Cancer Overview

Research Indicators

Publications Per Year (1990-2015)
Graph generated 17 August 2015 using data from PubMed using criteria.

Literature Analysis

Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.

Tag cloud generated 17 August, 2015 using data from PubMed, MeSH and CancerIndex

Specific Cancers (3)

Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.

Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).

Latest Publications: C2orf44 (cancer-related)

Lipson D, Capelletti M, Yelensky R, et al.
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.
Nat Med. 2012; 18(3):382-4 [PubMed] Free Access to Full Article Related Publications
Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma. Further screening of 561 lung adenocarcinomas identified 11 additional tumors with KIF5B-RET gene fusions (2.0%; 95% CI 0.8-3.1%). Cells expressing oncogenic KIF5B-RET are sensitive to multi-kinase inhibitors that inhibit RET.

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Cite this page: Cotterill SJ. C2orf44, Cancer Genetics Web: http://www.cancer-genetics.org/C2orf44.htm Accessed:

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This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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