SRD5A2 - steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

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SRD5A2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (2p23)
SRD5A2 Menu Summary Information - SRD5A2 Gene Database Entries for SRD5A2 Other SRD5A2 Related Resources SRD5A2 and Prostate Cancer SRD5A2 and Breast Cancer Feedback / suggest a new topic for SRD5A2
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Summary Information
SRD5A2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) Location: 2p23 Overview: The enzyme product of SRD5A2 is expressed in androgen-dependent tissues. It is responsible for converting testosterone to the more metabolically active dihydrotestosterone, which in turn transactivates a number of genes including prostate-specific antigen (PSA). There are a number of reports of polymorphisms and somatic mutations of SRD5A2 in prostate cancer. Polymorphisms of SRD5A2 have also been implicated in increased breast cancer risk (Bharaj, 2000). Return to SRD5A2 Contents
Gene Database Entries for SRD5A2
OMIM GeneCard (Weizmann Institute) Human Gene Mutation Database (Cardiff, UK) Genbank Swiss-Prot Locus Link (search for SRD5A2) UniGene GenAtlas GDB Nomenclature (search for SRD5A2) Return to SRD5A2 Contents
Other Related Resources
Search Medline for related articles (PubMed) *Medline Search:* cancer AND gene AND SRD5A2[TI] (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to SRD5A2 Contents
SRD5A2 and Prostate Cancer
Jaffe JM, et al. Association of SRD5A2 genotype and pathological characteristics of prostate tumors. Cancer Res 2000 Mar 15;60(6):1626-30 Related articles (PubMed) Lunn RM et al. Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reductase (SRD5A2). Carcinogenesis 1999; 20:1727-31 Related articles (PubMed) Akalu A et al. Somatic mutations at the SRD5A2 locus encoding prostatic steroid 5alpha-reductase during prostate cancer progression. J Urol 1999;161:1355-8 Related articles (PubMed) Reichardt JK et al. Genetic variability of the human SRD5A2 gene: implications for prostate cancer risk. Cancer Res. 1995; ;55:3973-5 Related articles (PubMed) *Medline Search:* prostate cancer AND SRD5A2 (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Prostate Cancer Genetics Prostate Cancer : Clinical and Epidemiological Information Return to SRD5A2 Contents
SRD5A2 and Breast Cancer
Bharaj B, et al. TA repeat polymorphism of the 5alpha-reductase gene and breast cancer. Cancer Epidemiol Biomarkers Prev 2000; 9(4):387-93 Related articles (PubMed) *Medline Search:* breast cancer AND SRD5A2 (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Breast Cancer Genetics Breast Cancer : Clinical and Epidemiological Information Return to SRD5A2 Contents
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SRD5A2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)