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SRD5A2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (2p23)
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    Summary Information - SRD5A2
    Gene Database Entries for SRD5A2
    Other SRD5A2 Related Resources
    SRD5A2 and Prostate Cancer
    SRD5A2 and Breast Cancer
    Feedback / suggest a new topic for SRD5A2


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  Summary Information

SRD5A2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

Location: 2p23

Overview: The enzyme product of SRD5A2 is expressed in androgen-dependent tissues. It is responsible for converting testosterone to the more metabolically active dihydrotestosterone, which in turn transactivates a number of genes including prostate-specific antigen (PSA). There are a number of reports of polymorphisms and somatic mutations of SRD5A2 in prostate cancer. Polymorphisms of SRD5A2 have also been implicated in increased breast cancer risk (Bharaj, 2000).

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  Gene Database Entries for SRD5A2

OMIM
GeneCard (Weizmann Institute)
Human Gene Mutation Database (Cardiff, UK)
Genbank
Swiss-Prot
Locus Link (search for SRD5A2)
UniGene
GenAtlas
GDB
Nomenclature (search for SRD5A2)

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  Other Related Resources

Search Medline for related articles (PubMed)
  • Medline Search: cancer AND gene AND SRD5A2[TI] (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]
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      SRD5A2 and Prostate Cancer

  • Jaffe JM, et al. Association of SRD5A2 genotype and pathological characteristics of prostate tumors. Cancer Res 2000 Mar 15;60(6):1626-30    Related articles (PubMed)

  • Lunn RM et al. Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reductase (SRD5A2). Carcinogenesis 1999; 20:1727-31    Related articles (PubMed)

  • Akalu A et al. Somatic mutations at the SRD5A2 locus encoding prostatic steroid 5alpha-reductase during prostate cancer progression. J Urol 1999;161:1355-8    Related articles (PubMed)

  • Reichardt JK et al. Genetic variability of the human SRD5A2 gene: implications for prostate cancer risk. Cancer Res. 1995; ;55:3973-5    Related articles (PubMed)

  • Medline Search: prostate cancer AND SRD5A2 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Prostate Cancer Genetics
    Prostate Cancer : Clinical and Epidemiological Information

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  •   SRD5A2 and Breast Cancer

  • Bharaj B, et al. TA repeat polymorphism of the 5alpha-reductase gene and breast cancer. Cancer Epidemiol Biomarkers Prev 2000; 9(4):387-93    Related articles (PubMed)

  • Medline Search: breast cancer AND SRD5A2 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
    Breast Cancer Genetics
    Breast Cancer : Clinical and Epidemiological Information

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