 Summary Information
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Location: 2q14
Aliases: AMPHL, SH3P9
The Bin1 gene encodes a c-Myc-interacting adapter protein which has tumor suppressor and cell death properties.
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| Gene Database Entries for BIN1
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OMIM
GeneCard (Weizmann Institute)
Genbank
Swiss-Prot
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for BIN1)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (BIN1[TI] OR AMPHL[TI] OR SH3P9[TI]) (PubMed)
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| BIN1 and Cancer
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DuHadaway JB, et al. Bin1 mediates apoptosis by c-Myc in transformed primary cells. Cancer Res 2001;61(7):3151-6 Related articles (PubMed)
Elliott K, et al. The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program. Oncogene 2000;19(41):4669-84 Related articles (PubMed)
Elliott K, et al. Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms. Oncogene. 1999 Jun 17;18(24):3564-73. Related articles (PubMed)
Wechsler-Reya R, et al. The putative tumor suppressor BIN1 is a short-lived nuclear phosphoprotein, the localization of which is altered in malignant cells. Cancer Res. 1997 Aug 1;57(15):3258-63. Related articles (PubMed)
Sakamuro D, et al. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet. 1996 Sep;14(1):69-77 Related articles (PubMed)
Medline Search: cancer AND (bin1 OR amphl) (PubMed)
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| BIN1 and Breast Cancer
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Ge K, Duhadaway J, et al. Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity. Int J Cancer 2000 Feb 1;85(3):376-83 Related articles (PubMed)
Sakamuro D, et al. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet. 1996 Sep;14(1):69-77 Related articles (PubMed)
Medline Search: breast cancer AND (bin1 OR amphl) (PubMed)
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- Related Resources
 Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| BIN1 and Melanoma
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Ge K, DuHadaway J, et al. Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma. Proc Natl Acad Sci USA 1999 Aug 17;96(17):9689-94 Related articles (PubMed)
Medline Search: melanoma AND (bin1 OR amphl) (PubMed)
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Melanoma Genetics
Melanoma : Clinical and Epidemiological Information
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| BIN1 and Prostate Cancer
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Ge K, et al. Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma. Int J Cancer 2000; 86(2):155-61 Related articles (PubMed)
Medline Search: prostate cancer AND (bin1 OR amphl) (PubMed)
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- Related Resources
Prostate Cancer Genetics
Prostate Cancer : Clinical and Epidemiological Information
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| Reduced BIN1 expression in MYCN amplified Neuroblastoma
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Hogarty MD, et al. BIN1 inhibits colony formation and induces apoptosis in neuroblastoma cell lines with MYCN amplification. Med Pediatr Oncol 2000;35(6):559-62 Related articles (PubMed)
Medline Search: neuroblastoma AND (bin1 OR amphl) (PubMed)
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- Related Resources
- MYCN gene
Neuroblastoma Genetics
Neuroblastoma : Clinical and Epidemiological Information
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[Home] This page created: 10/03/2000 Last revised: 29/04/2003 © Copyright 1999-
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