NTRK1 - Neurotrophic tyrosine kinase, receptor, type 1 - aka: TRKA

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NTRK1; Neurotrophic tyrosine kinase, receptor, type 1 (1q21-q22)
NTRK1 Menu Summary Information - NTRK1 Gene Database Entries for NTRK1 Other NTRK1 Related Resources NRTK1 and Papillary Thyroid Carcinoma NTRK1 and Neuroblastoma Feedback / suggest a new topic for NTRK1
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Summary Information
NTRK1; Neurotrophic tyrosine kinase, receptor, type 1 Location: 1q21-q22 Alias: TRKA Overview: NTRK1 (TRKA) is one of three known neurotrophic tyrosine kinase resceptors. The neurotrophins (and their receptors) help regulate the development of both the central nervous system (CNS) and the peripheral nervous systems (PNS). Return to NTRK1 Contents
Gene Database Entries for NTRK1
OMIM GeneCard (Weizmann Institute) Human Gene Mutation Database (Cardiff, UK) Swiss-Prot Locus Link UniGene GenAtlas GDB Nomenclature (search for NTRK1) Return to NTRK1 Contents
Other Related Resources
Neuroblastoma Resources *Medline Search:* NTRK1 OR TRKA (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Search Medline for related articles (PubMed) *Medline Search:* cancer AND gene AND (NTRK1[TI] OR TRKA[TI]) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to NTRK1 Contents
NRTK1 and Papillary Thyroid Carcinoma
Butti MG et al. A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas. Genomics 1995;28:15-24 Related articles (PubMed) Bongarzone I et al. RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: correlation with clinicopathological features. Clin Cancer Res 1998 4:223-8 Related articles (PubMed) *Medline Search:* NRTK1 AND thyroid carcinoma (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources RET gene Thyroid Cancer Genetics Thyroid Cancer : Clinical and Epidemiological Information Return to NTRK1 Contents
NTRK1 and Neuroblastoma
Expression of TRKA in neuroblastoma is associated with low stage and age < 1yr at diagnosis. It is negatively correlated with unfavourable genetic features such as MYCN amplification and 1p deletion. Eggert A, et al. Prognostic and biological role of neurotrophin-receptor TrkA and TrkB in neuroblastoma. Klin Padiatr 2000 Jul-Aug;212(4):200-5 Related articles (PubMed) Shikata A, et al. Neuronal differentiation in human neuroblastoma cells by nerve growth factor following TrkA up-regulation by interferon-gamma. Med Pediatr Oncol. 2000;34(6):394-401. Related articles (PubMed) Kramer K et al. Correlation of MYCN amplification, Trk-A and CD44 expression with clinical stage in 250 patients with neuroblastoma. Eur J Cancer 1997;33:2098-100 Related articles (PubMed) Brodeur GM Molecular basis for heterogeneity in human neuroblastomas. (Review) Eur J Cancer 1995;31A:505-10 Related articles (PubMed) Nakagawara A, et al. Inverse relationship between trk expression and N-myc amplification in human neuroblastomas. Cancer Res. 1992; 52(5):1364-8 Related articles (PubMed) *Medline Search:* NTRK1 AND neuroblastoma (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources NTRK2 (trkB) NTRK3 (trkC) Neuroblastoma Genetics Neuroblastoma : Clinical and Epidemiological Information Return to NTRK1 Contents
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NTRK1; Neurotrophic tyrosine kinase, receptor, type 1