 Mutated Genes and Abnormal Protein Expression
|
| Gene | Location | Topics
|
| MTHFR (
NADPH
)
| 1p36.3
|
-MTHFR and Acute Lymphoblastic Leukaemia
|
| MME (
CALLA
, CD10
, NEP
)
| 3q21-q27
|
|
| TCRG (
TRG
)
| 7p15-p14
|
-TCRG and T cell Acute Lymphoblastic Leukaemia
|
| TCRB (
TRB
)
| 7q35
|
-TCRB and T cell Acute Lymphoblastic Leukaemia
|
| ABL1 (
ABL
, JTK7
)
| 9q34.1
|
-Philadelphia Chromosome in Acute Lymphoblastic Leukaemia
|
| NOTCH1 (
TAN1
)
| 9q34.3
|
-t(7;9)(q34;q34.3) in T-Cell Acute Lymphoblastic Leukaemia
|
| AF10 (
ALL1
)
| 10p12
|
|
| TNFRSF6 (
CD95
, FAS
, APO1
)
| 10q24.1
|
-FAS and T-cell Acute Lymphoblastic Leukaemia
|
| LMO2 (
RBTNL1
, TTG2
)
| 11p13
|
-LMO2 and Acute Lymphocytic Leukaemia
|
| LMO1 (
TTG1
, RBTN1
, LIM
)
| 11p15
|
-t(11;14)(p15;q11) and LMO1 in T-ALL ?
|
| CALM (
CLTH
)
| 11q14-21
|
|
| RARA | 17q12
|
|
| BCL2 | 18q21.3
|
-t(14;18)(q32;q21) in Acute Lymphoblastic Leukaemia
|
| LYL1 | 19p13.2-p13.1
|
-t(7;9)(q35;p13) in T-cell Acute Lymphoblastic Leukemia
|
| BAX | 19q13.3-q13.4
|
-BAX and Childhood Acute Lymphocytic Leukemia
|
| CBFA2 (
AML1
, PEBP2A2
, RUNX1
)
| 21q22.3
|
|
| BCR (
BCR1
, D22S11
)
| 22q11
|
-Philadelphia Chromosome in Acute Lymphoblastic Leukaemia
|
| MLLT7 (
AFX1
)
| Xq13.1
|
|
|
Acute Lymphocytic Leukaemia: Clinical and Epidemiological Resources