Summary Information - PBX1 Gene Database Entries for PBX1 Other PBX1 Related Resources t(1;19)(q23;p13.3) in pre-B-cell ALL Feedback / suggest a new topic for PBX1
PBX1; Pre-B-cell leukemia transcription factor 1 Location: 1q23 Return to PBX1 Contents
Location: 1q23
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OMIM GeneCard (Weizmann Institute) Atlas of Genetics and Cytogenetics in Oncology and Haematology Tumor Gene Database Genbank Swiss-Prot Locus Link (search for PBX1) UniGene GenAtlas GDB Nomenclature (search for PBX1) Return to PBX1 Contents
Search Medline for related articles (PubMed) Medline Search: cancer AND gene AND PBX1[TI] (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to PBX1 Contents
t(1;19)(q23;p13.3) translocations fusing the PBX1 and E2A genes occur in approximately a quater of paediatric pre-B cell acute lymphoblastic laeukemias. LeBrun DP, et al. Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias. Oncogene. 1994; 9(6):1641-7. Related articles (PubMed) Lu Q, et al. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. Mol Cell Biol. 1994;14(6):3938-48 Related articles (PubMed) Kamps MP, et al. The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. Genes Dev 1991; 5(3):358-68 Related articles (PubMed) Izraeli S, et al. Expression of identical E2A/PBX1 fusion transcripts occurs in both pre-B and early pre-B immunological subtypes of childhood acute lymphoblastic leukemia Leukemia. 1993;7(12):2054-6. Related articles (PubMed) Medline Search: pre-B-cell acute lymphoblastic leukemia AND translocation (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Childhood Leukaemia Genetics Childhood Leukaemia : Clinical and Epidemiological Information Return to PBX1 Contents
PBX1; Pre-B-cell leukemia transcription factor 1 (1q23)
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Childhood Leukaemia Genetics