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  Chromosome 16

Genes Linked with Cancer (70)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 16; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
IL27 16p11 p28, IL30, IL-27, IL27A, IL-27A, IL27p28-Bone Cancer (primary)
-Ovarian Cancer
-Prostate Cancer
IL21R 16p11 NILR, CD360Somatic-Acute Myeloid Leukaemia
-Leukaemia
CD19 16p11.2 B4, CVID3-Acute Myeloid Leukaemia
-Childhood Cancers
-Chronic Lymphocytic Leukemia
-Multiple Myeloma
MVP 16p11.2 LRP, VAULT1-Brain Tumours, Childhood
-Breast Cancer
-Childhood Cancers
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
PYCARD 16p11.2 ASC, TMS, TMS1, CARD5, TMS-1-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
MAPK3 16p11.2 ERK1, ERT2, ERK-1, PRKM3, P44ERK1, P44MAPK, HS44KDAP, HUMKER1A, p44-ERK1, p44-MAPK-Bladder Cancer
-Cervical Cancer
-Salivary Gland Cancer
-Uterine Sarcoma
FUS 16p11.2 TLS, ALS6, ETM4, FUS1, POMP75, HNRNPP2Somatic
Translocation
-Acute Myeloid Leukaemia
-Childhood Cancers
-Skin Cancer
-Soft Tissue Sarcoma
ITGAM 16p11.2 CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6-Acute Myeloid Leukaemia
-Leukaemia
-Skin Cancer
ITGAX 16p11.2 CD11C, SLEB6-Chronic Lymphocytic Leukemia
-Hairy Cell Leukemia
ITGAL 16p11.2 CD11A, LFA-1, LFA1A-Leukaemia
-Multiple Myeloma
SULT1A1 16p12.1 PST, STP, STP1, P-PST, ST1A1, ST1A3, TSPST1, HAST1/HAST2-Breast Cancer
-Male Breast Cancer
IL4R 16p12.1-p11.2 CD124, IL4RA, IL-4RA-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Hodgkin Lymphoma
PLK1 16p12.2 PLK, STPK13-Breast Cancer
-Liver Cancer
-Lung Cancer
PALB2 16p12.2 FANCN, PNCA3Germline-Fanconi Anaemia
CIITA 16p13 C2TA, NLRA, MHC2TA, CIITAIVSomatic-Melanoma
ABCC1 16p13.1 MRP, ABCC, GS-X, MRP1, ABC29Many cancer types including:
-Acute Lymphocytic Leukemia (ALL), child
-Acute Myeloid Leukaemia
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Neuroblastoma
-Ovarian Cancer
-Salivary Gland Cancer
TNFRSF17 16p13.1 BCM, BCMA, CD269, TNFRSF13ASomatic-Childhood Cancers
-Chronic Lymphocytic Leukemia
-Multiple Myeloma
-Stomach Cancer
MYH11 16p13.11 AAT4, FAA4, SMHC, SMMHCSomatic
Translocation
-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
-Wilms Tumour
ERCC4 16p13.12 XPF, RAD1, FANCQ, ERCC11Germline-Bladder Cancer
-Breast Cancer
-Lung Cancer
RMI2 16p13.13 BLAP18, C16orf75Somatic-Bone Cancer (primary)
SOCS1 16p13.13 JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1Somatic-Colorectal Cancer
-Liver Cancer
-Stomach Cancer
SNX29 16p13.13-p13.12 RUNDC2A, A-388D4.1Somatic
AXIN1 16p13.3 AXIN, PPP1R49-Colorectal Cancer
-Liver Cancer
CREBBP 16p13.3 CBP, RSTS, KAT3ASomatic-Breast Cancer
-Esophageal Cancer
PKD1 16p13.3 PBP, Pc-1, TRPP1-Prostate Cancer
-Stomach Cancer
PDPK1 16p13.3 PDK1, PDPK2, PDPK2P, PRO0461-Breast Cancer
-Prostate Cancer
-Stomach Cancer
IL32 16p13.3 NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, IL-32beta, IL-32alpha, IL-32delta, IL-32gamma-Breast Cancer
-Cutaneous T-cell lymphoma
-Mycosis Fungoides
-Skin Cancer
SSTR5 16p13.3 SS-5-R-Breast Cancer
-Pancreatic Cancer
-Pituitary Tumors
-Prostate Cancer
-Stomach Cancer
-Thyroid Cancer
USP7 16p13.3 TEF1, HAUSP-Breast Cancer
TSC2 16p13.3 LAM, TSC4, PPP1R160Germline-Childhood Cancers
-Kidney Cancer
-Lung Cancer
-Uterine Sarcoma
MSLN 16p13.3 MPF, SMRP-Cervical Cancer
-Mesothelioma
-Ovarian Cancer
-Pancreatic Cancer
CYLD 16q12.1 EAC, MFT, SBS, TEM, BRSS, CDMT, MFT1, CYLD1, CYLDI, USPL2Germline & Somatic-Adenoid Cystic Carcinoma
-Childhood Cancers
-Salivary Gland Cancer
-Skin Cancer
-Basal Cell Carcinoma (BCC) - Skin
TOX3 16q12.1 CAGF9, TNRC9-Breast Cancer
RBL2 16q12.2 Rb2, P130-Endometrial Cancer
-Intraocular (Eye) Melanoma
-Lung Cancer
-Nasopharyngeal Cancer
-Neuroblastoma
-Retinoblastoma
CCL17 16q13 TARC, ABCD-2, SCYA17, A-152E5.3-Chronic Lymphocytic Leukemia
-Cutaneous T-cell lymphoma
-Hodgkin Lymphoma
-Lung Cancer
-Skin Cancer
CX3CL1 16q13 NTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine, fractalkine, neurotactin-Brain Tumours, Childhood
-Breast Cancer
-Ovarian Cancer
-Pancreatic Cancer
MT1G 16q13 MT1, MT1K-Breast Cancer
-Esophageal Cancer
-Kidney Cancer
-Liver Cancer
-Lung Cancer
-Thyroid Cancer
MT2A 16q13 MT2-Breast Cancer
-Colorectal Cancer
-Nasopharyngeal Cancer
-Prostate Cancer
-Stomach Cancer
CCL22 16q13 MDC, ABCD-1, SCYA22, STCP-1, DC/B-CK, A-152E5.1-Breast Cancer
-Hodgkin Lymphoma
-Lung Cancer
-Stomach Cancer
HERPUD1 16q13 SUP, HERP, Mif1Somatic-Leukaemia
-Lung Cancer
-Prostate Cancer
-Uterine Sarcoma
MMP2 16q13-q21 CLG4, MONA, CLG4A, MMP-2, TBE-1, MMP-II-Brain and CNS Tumours
-Breast Cancer
-Cervical Cancer
-Chondrosarcoma
-Colorectal Cancer
-Liver Cancer
-Melanoma
-Oral Cavity Cancer
-Osteosarcoma
-Ovarian Cancer
-Stomach Cancer
NOD2 16q21 CD, ACUG, BLAU, IBD1, NLRC2, NOD2B, CARD15, CLR16.3, PSORAS1-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Colorectal Cancer
-Haematological Malignancies
-Skin Cancer
CDH11 16q21 OB, CAD11, CDHOB, OSF-4Somatic-Retinoblastoma
CTCF 16q21-q22.3 MRD21-Breast Cancer
-Stomach Cancer
-Testicular Cancer
-Wilms Tumour
AMFR 16q21 GP78, RNF45-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
-Prostate Cancer
MAF 16q22-q23 CCA4, c-MAFSomatic-Breast Cancer
-Multiple Myeloma
-Prostate Cancer
TRADD 16q22 Hs.89862-Breast Cancer
TERF2 16q22.1 TRF2, TRBF2-Breast Cancer
CDH1 16q22.1 UVO, CDHE, ECAD, LCAM, Arc-1, CD324Germline & Somatic-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Stomach Cancer
NQO1 16q22.1 DTD, QR1, DHQU, DIA4, NMOR1, NMORI-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Skin Cancer
-Urinary System Cancers
E2F4 16q22.1 E2F-4-Breast Cancer
-Colorectal Cancer
CDH3 16q22.1 CDHP, HJMD, PCAD-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Pancreatic Cancer
-Stomach Cancer
HAS3 16q22.1 -Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Prostate Cancer
CBFB 16q22.1 PEBP2BSomatic
Translocation
-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
WWOX 16q23 FOR, WOX1, FRA16D, SCAR12, HHCMA56, PRO0128, SDR41C1, D16S432E-Bladder Cancer
-Breast Cancer
-Lung Cancer
BCAR1 16q23.1 CAS, CAS1, CASS1, CRKAS, P130Cas-Breast Cancer
-Prostate Cancer
CDH13 16q23.3 CDHH, P105-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Prostate Cancer
-Retinoblastoma
BANP 16q24 BEND1, SMAR1, SMARBP1-Breast Cancer
-Lung Cancer
APRT 16q24 AMP, APRTD-Colorectal Cancer
-Skin Cancer
CYBA 16q24 p22-PHOX-Breast Cancer
-Non-Hodgkin Lymphoma
-Pancreatic Cancer
-Skin Cancer
-Stomach Cancer
CBFA2T3 16q24 ETO2, MTG16, MTGR2, ZMYND4Somatic-Acute Myeloid Leukaemia
-Breast Cancer
-Childhood Cancers
-Leukaemia
IL17C 16q24 CX2, IL-17C-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
HSD17B2 16q24.1-q24.2 HSD17, SDR9C2, EDH17B2-Breast Cancer
-Endometrial Cancer
-Ovarian Cancer
-Prostate Cancer
FOXC2 16q24.1 LD, MFH1, MFH-1, FKHL14-Breast Cancer
-Cervical Cancer
-Lung Cancer
IRF8 16q24.1 ICSBP, IRF-8, ICSBP1, IMD32A, IMD32B, H-ICSBP-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
TUBB3 16q24.3 CDCBM, FEOM3, TUBB4, CDCBM1, CFEOM3, beta-4, CFEOM3A-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
MC1R 16q24.3 CMM5, MSH-R, SHEP2-Eye Cancer
-Melanoma
-Basal Cell Carcinoma (BCC) - Skin
SLC7A5 16q24.3 E16, CD98, LAT1, 4F2LC, MPE16, hLAT1, D16S469E-Bladder Cancer
-Lung Cancer
-Ovarian Cancer
FANCA 16q24.3 FA, FA1, FAA, FAH, FA-H, FACA, FANCHGermline-Fanconi Anaemia
CDT1 16q24.3 DUP, RIS2-Skin Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 16:

Abnormality Type Gene(s)
LOH 16q in Wilms' TumourLOH
LOH in 6q27 in Serous Ovarian CarcinomaLOH
der(16)t(1;16) in Ewing's SarcomaTranslocation
t(16;16)(p13q22) CBFB-MYH11 Translocation in AMLTranslocationCBFB (16q22.1)MYH11 (16p13.11)
t(16;21)(p11;q22) in Leukemia (ANLL)TranslocationFUS (16p11.2)ERG (21q22.3)
t(12;16)(q13;p11) FUS-DDIT3 in Mixoid LiposarcomaTranslocationFUS (16p11.2)DDIT3 (12q13.1-q13.2)
t(16;21)(p11;q22) FUS-ERG in Acute Myelogenous LeukemiaTranslocationFUS (16p11.2)ERG (21q22.3)
t(7;16)(q33;p11) FUS-CREB3L2 in Low-grade fibromyxoid sarcomaTranslocationFUS (16p11.2)CREB3L2 (7q34)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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Cite this page: Cotterill SJ. Chromosome 16, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc16.htm Accessed: date

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