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  Chromosome 16

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 16; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
IL21R 16p11 NILR, CD360Somatic
MVP 16p11.2 LRP, VAULT1
CD19 16p11.2 B4, CVID3
FUS 16p11.2 TLS, ALS6, ETM4, FUS1, POMP75, HNRNPP2Somatic
Translocation
-Acute Myeloid Leukaemia
-Soft Tissue Sarcoma
SULT1A1 16p12.1 PST, STP, STP1, P-PST, ST1A1, ST1A3, TSPST1, HAST1/HAST2-Breast Cancer
-Male Breast Cancer
PALB2 16p12.2 FANCN, PNCA3Germline-Fanconi Anaemia
CIITA 16p13 C2TA, NLRA, MHC2TA, CIITAIVSomatic
TNFRSF17 16p13.1 BCM, BCMA, CD269, TNFRSF13ASomatic
ABCC1 16p13.1 MRP, ABCC, GS-X, MRP1, ABC29
MYH11 16p13.11 AAT4, FAA4, SMHC, SMMHCSomatic
Translocation
-Acute Myeloid Leukaemia
ERCC4 16p13.12 XPF, RAD1, FANCQ, ERCC11Germline
RMI2 16p13.13 BLAP18, C16orf75Somatic
SOCS1 16p13.13 JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1Somatic
SNX29 16p13.13-p13.12 RUNDC2A, A-388D4.1Somatic
CREBBP 16p13.3 CBP, RSTS, KAT3ASomatic
TSC2 16p13.3 LAM, TSC4Germline
AXIN1 16p13.3 AXIN, PPP1R49
CYLD 16q12.1 EAC, MFT, SBS, TEM, BRSS, CDMT, MFT1, CYLD1, CYLDI, USPL2Germline & Somatic
RBL2 16q12.2 Rb2, P130
HERPUD1 16q13 SUP, HERP, Mif1Somatic
MMP2 16q13-q21 CLG4, MONA, CLG4A, TBE-1, MMP-II
CDH11 16q21 OB, CAD11, CDHOB, OSF-4Somatic
MAF 16q22-q23 CCA4, c-MAFSomatic
CDH1 16q22.1 UVO, CDHE, ECAD, LCAM, Arc-1, CD324Germline & Somatic
CBFB 16q22.1 PEBP2BSomatic
Translocation
-Acute Myeloid Leukaemia
BCAR1 16q23.1 CAS, CAS1, CASS1, CRKAS, P130Cas
CDH13 16q23.3 CDHH, P105
CBFA2T3 16q24 ETO2, MTG16, MTGR2, ZMYND4Somatic
MC1R 16q24.3 CMM5, MSH-R, SHEP2
FANCA 16q24.3 FA, FA1, FAA, FAH, FA-H, FACA, FANCHGermline-Fanconi Anaemia

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 16:

Abnormality Type Gene(s)
LOH 16q in Wilms' TumourLOH
der(16)t(1;16) in Ewing's SarcomaTranslocation
t(16;16)(p13q22) CBFB-MYH11 Translocation in AMLTranslocationCBFB (16q22.1)MYH11 (16p13.11)
t(16;21)(p11;q22) in Leukemia (ANLL)TranslocationFUS (16p11.2)ERG (21q22.3)
t(12;16)(q13;p11) FUS-DDIT3 in Mixoid LiposarcomaTranslocationFUS (16p11.2)DDIT3 (12q13.1-q13.2)
t(16;21)(p11;q22) FUS-ERG in Acute Myelogenous LeukemiaTranslocationFUS (16p11.2)ERG (21q22.3)
t(7;16)(q33;p11) FUS-CREB3L2 in Low-grade fibromyxoid sarcomaTranslocationFUS (16p11.2)CREB3L2 (7q34)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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