 Summary Information
|
Location: 16p13.1
Aliases: MRP1, ABCC1
Associated with multidrug resistance in a wide range of cancers and a marker of tumor aggressiveness
 Return to MRP Contents
|
| Gene Database Entries for MRP
|
OMIM
GeneCard (Weizmann Institute)
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Locus Link
UniGene
GenAtlas
GDB
Nomenclature (search for MRP)
Return to MRP Contents
|
| Other Related Resources
|
- Search Medline for related articles (PubMed)
-
- Medline Search: cancer AND gene AND (MRP[TI] OR MRP1[TI] OR ABCC1[TI]) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
Return to MRP Contents
|
| Defining Texts
|
Cole SP, et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 1992; 258(5088):1650-4 Related articles (PubMed)
Zaman GJ, et al. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci USA. 1994; 91(19):8822-6 Related articles (PubMed)
Medline Search: gene AND (MRP OR MRP1) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
Return to MRP Contents
|
| MRP1 and Cancer (general)
|
Dicato M, et al. Multidrug resistance: molecular and clinical aspects. [Review] Cytokines Cell Mol Ther 1997; 3(2):91-9 Related articles (PubMed)
Medline Search: cancer AND (MRP OR MRP1) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
 Resources by Disease Type
Return to MRP Contents
|
| MRP1 and Neuroblastoma
|
Haber M, et al. Altered expression of the MYCN oncogene modulates MRP gene expression and response to cytotoxic drugs in neuroblastoma cells. Oncogene 1999 Apr 29;18(17):2777-82 Related articles (PubMed)
Bader P, et al. Expression analysis of multidrug resistance associated genes in neuroblastomas. Oncol Rep 1999; 6(5):1143-6 Related articles (PubMed)
Norris MD, et al. Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma. N Engl J Med 1996; 334(4):231-8 Related articles (PubMed)
Medline Search: neuroblastoma AND (MRP OR MRP1) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
- MYCN gene
Neuroblastoma Genetics
Neuroblastoma : Clinical and Epidemiological Information
Return to MRP Contents
|
| MRP1 and Lung Cancer
|
Medline Search: lung cancer AND (MRP OR MRP1) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Lung Cancer Genetics
Lung Cancer : Clinical and Epidemiological Information
Return to MRP Contents
|
| MRP1 and CNS Tumours
|
Nagane M, et al. Expression Pattern of Chemoresistance-related Genes in Human Malignant Brain Tumors: a Working Knowledge for Proper Selection of Anticancer Drugs Japan J Clin Oncol 1999; 29(11): 527-34 Related articles
Medline Search: brain tumor AND (MRP OR MRP1) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Brain and CNS Tumours : Clinical and Epidemiological Information
Return to MRP Contents
|
| MRP1 and Acute Myeloid Leukaemia
|
Legrand O, et al. Role of MRP1 in multidrug resistance in acute myeloid leukemia. Leukemia 1999 Apr;13(4):578-84 Related articles (PubMed)
Medline Search: acute myeloid leukemia AND (MRP OR MRP1) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Acute Myeloid Leukaemia Genetics
Acute Myeloid Leukaemia : Clinical and Epidemiological Information
Return to MRP Contents
|
| MRP1 Deletion in Acute Myeloid Leukaemia with INV(16)
|
van Der Kolk DM, et al. Deletion of the multidrug resistance protein MRP1 gene in acute myeloid leukemia: the impact on MRP activity. Blood 2000 Jun 1;95(11):3514-9 Related articles (PubMed)
Dohner K, et al. Deletion of the multidrug resistance-associated protein (MRP1) gene in acute myeloid leukemia with inversion of chromosome 16 has no prognostic impact. Leukemia 2000 Jun;14(6):1154 Related articles (PubMed)
Kuss BJ, et al. Deletion of gene for multidrug resistance in acute myeloid leukaemia with inversion in chromosome 16: prognostic implications. Lancet 1994 Jun 18;343(8912):1531-4 Related articles (PubMed)
Medline Search: (MRP OR MRP1) AND acute myeloid leukemia AND chromosome 16 (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Acute Myeloid Leukaemia Genetics
Acute Myeloid Leukaemia : Clinical and Epidemiological Information
Return to MRP Contents
|
| MRP1 Expression in Childhood Leukaemia
|
den Boer ML, et al. Relationship between major vault protein/lung resistance protein, drug resistance in childhood leukemia. Blood 1998 Mar 15;91(6):2092-8 Related articles (PubMed)
Ogretmen B, et al. Increased expression of lung resistance-related protein and multidrug resistance-associated protein messenger RNA in childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2000 Jan-Feb;22(1):45-9 Related articles (PubMed)
Medline Search: childhood leukaemia AND (MRP OR MRP1) (PubMed)
Limit search to: [Last Year] Limit search to: [Last 2 Years]
Limit search to: [Reviews]
- Related Resources
Childhood Leukaemia Genetics
Childhood Leukaemia : Clinical and Epidemiological Information
Return to MRP Contents
|
|
[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
|
