Over 90% of Ewing's sarcomas contain a t(11;22)(q24;q12) translocation which fuses the EWS gene on chromosome 22 with the FLI1 gene on chromosome 11. This genetic feature defines the Ewing's family of tumours
(Ewing's sarcomas, peripheral primitive neuroectodermal tumours (pPNET) and Askin's tumours). In a minority of Ewing's tumours the EWS gene has a different fusion partner including the ERG, ETV1 and the EA1F and genes. The Ewing's family of tumours also strongly express the MIC2 (CD99) antigen.
Ginsberg JP, et al. EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma. J Clin Oncol 1999; 17(6):1809-14 Related articles (PubMed)
Kovar H, et al. The Ewing family of tumors and the search for the Achilles' heel. [Review] Curr Opin Oncol. 1999;11(4):275-84. [Review] Related articles (PubMed)
Kovar H. Ewing's sarcoma and peripheral primitive neuroectodermal tumors after their genetic union. Curr Opin Oncol. 1998;10(4):334-42. [Review] Related articles (PubMed)
Delattre O. et al. The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 1994; 331:294-9 Related articles (PubMed)
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 del(1p36) in Ewing's Sarcoma
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Hattinger CM, et al. Prognostic impact of deletions at 1p36 and numerical aberrations in Ewing tumors. Genes Chromosomes Cancer 1999;24(3):243-54 Related articles (PubMed)
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| 1q Gain in Ewing's Sarcoma
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Kullendorff CM, et al. Cytogenetic aberrations in Ewing sarcoma: are secondary changes associated with clinical outcome? Med Pediatr Oncol 1999 Feb;32(2):79-83 Related articles (PubMed)
Stark B, et al. Additional chromosome 1q aberrations and der(16)t(1;16), correlation to the phenotypic expression and clinical behavior of the Ewing family of tumors. J Neurooncol 1997 Jan;31(1-2):3-8 Related articles (PubMed)
Armengol G, et al. Recurrent gains of 1q, 8 and 12 in the Ewing family of tumours by comparative genomic hybridization. Br J Cancer 1997;75(10):1403-9 Related articles (PubMed)
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| der(16)t(1;16) in Ewing's Sarcoma
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Stark B, et al. Additional chromosome 1q aberrations and der(16)t(1;16), correlation to the phenotypic expression and clinical behavior of the Ewing family of tumors. J Neurooncol 1997 Jan;31(1-2):3-8 Related articles (PubMed)
Hattinger CM, et al. Demonstration of the translocation der(16)t(1;16)(q12;q11.2) in interphase nuclei of Ewing tumors. Genes Chromosomes Cancer 1996 Nov;17(3):141-50 Related articles (PubMed)
Mugneret F, et al. Chromosomes in Ewing's sarcoma. II. Nonrandom additional changes, trisomy 8 and der(16)t(1;16). Cancer Genet Cytogenet 1988 Jun;32(2):239-45 Related articles (PubMed)
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| Trisomy 8 in Ewing's Sarcoma
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Armengol G, et al. Recurrent gains of 1q, 8 and 12 in the Ewing family of tumours by comparative genomic hybridization. Br J Cancer 1997;75(10):1403-9 Related articles (PubMed)
Maurici D, et al. Frequency and implications of chromosome 8 and 12 gains in Ewing sarcoma. Cancer Genet Cytogenet 1998 Jan 15;100(2):106-10 Related articles (PubMed)
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| Trisomy 12 in Ewing's Sarcoma
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Maurici D, et al. Frequency and implications of chromosome 8 and 12 gains in Ewing sarcoma. Cancer Genet Cytogenet 1998 Jan 15;100(2):106-10 Related articles (PubMed)
Armengol G, et al. Recurrent gains of 1q, 8 and 12 in the Ewing family of tumours by comparative genomic hybridization. Br J Cancer 1997;75(10):1403-9 Related articles (PubMed)
Mugneret F, et al. Chromosomes in Ewing's sarcoma. II. Nonrandom additional changes, trisomy 8 and der(16)t(1;16). Cancer Genet Cytogenet 1988 Jun;32(2):239-45 Related articles (PubMed)
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| LDH Expression in Ewing's Sarcoma
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Bacci G, et al. Prognostic significance of serum LDH in Ewing's sarcoma of bone. Oncol Rep 1999 Jul-Aug;6(4):807-11 Related articles (PubMed)
Craft AW, et al. Long-term results from the first UKCCSG Ewing's Tumour Study (ET-1). United Kingdom Children's Cancer Study Group (UKCCSG) and the Medical Research Council Bone Sarcoma Working Party. Eur J Cancer 1997 Jun;33(7):1061-9 Related articles (PubMed)
Bacci G, et al. Serum lactate dehydrogenase (LDH) as a tumor marker in Ewing's sarcoma. Tumori 1988 Dec 31;74(6):649-55 Related articles (PubMed)
Farley FA, et al. Lactase dehydrogenase as a tumor marker for recurrent disease in Ewing's sarcoma. Cancer 1987 Apr 1;59(7):1245-8 Related articles (PubMed)
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