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CCK; Cholecystokinin

Location: 3pter-p21

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In a study of diverse tumour cell lines Friedman (1992) reported that only a subset of tumors were found to expresses the cholecystokinin gene, in particular; 8/8 neuroepitheliomas, 8/8 Ewing sarcoma amd 2/6 rhabdomyosarcoma. In a study of paediatric primary tumours Schaer (1999) found that CCK cRNA expression was predominatly resrticted to 9/11 Ewing sarcomas and 5/10 leiomyosarcomas.

Schaer JC, et al. High gastrin and cholecystokinin (CCK) gene expression in human neuronal, renal, and myogenic stem cell tumors: comparison with CCK-A and CCK-B receptor contents. J Clin Endocrinol Metab 1999 Jan;84(1):233-9    Related articles (PubMed)

Friedman JM, et al. Expression of the cholecystokinin gene in pediatric tumors. Proc Natl Acad Sci U S A 1992 Jul 1;89(13):5819-23    Related articles (PubMed)

Related Resources
Ewing's Sarcoma Genetics
Ewing's Sarcoma : Clinical and Epidemiological Information

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