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    EAT2 is Upregulated by Ewing's Sarcoma EWS/FLI1 Fusion Genes
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EAT2; EWS/FLI1 activated transcript 2 - MOUSE GENE

Location: 1q22

MOUSE GENE

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The EWS/FLI1 fusion protein is created by t(11;22) translocation which is found in over 90% of Ewing's sarcomas. In a study of genes up regulated by EWS/FLI1 but not by full-length FLI1 (Thompson et al, 1996) characterised a novel gene EAT2 which was cloned from a mouse cDNA library. EAT2 expression correlated with transformation of NIH3T3 cells by EWS/FLI1chimeric proteins but not by unrelated genes. They identified a homologous sequence in humans mapped to chromosome 1q22 and detected human EAT-2 transcripts in Ewing's sarcoma cell lines by RT-PCR. In a later report (Thompson, 1999) the variant EWS/ETV1 translocation was also shown to upregulate EAT2.

Thompson AD, et al. Divergent Ewing's sarcoma EWS/ETS fusions confer a common tumorigenic phenotype on NIH3T3 cells. Oncogene 1999 Sep 30;18(40):5506-13    Related articles (PubMed)

Thompson AD, et al. EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. Oncogene 1996 Dec 19;13(12):2649-58    Related articles (PubMed)

Medline Search: cancer AND (eat2 OR eat-2) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
Ewing's Sarcoma Genetics
Ewing's Sarcoma : Clinical and Epidemiological Information

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