|Gene:||SH2D1B; SH2 domain containing 1B|
|Summary:||By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008]|
|Databases:||OMIM, VEGA, HGNC, Ensembl, GeneCard, Gene|
|Protein:||SH2 domain-containing protein 1B|
|Source:||NCBIAccessed: 17 August, 2015|
What does this gene/protein do?
|Pathways:||What pathways are this gene/protein implicaed in?|
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Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Ewing's Sarcoma||SH2D1B (EAT2) is Upregulated by Ewing's Sarcoma EWS/FLI1 Fusion Genes|
In a study of genes up regulated by EWS/FLI1 but not by full-length FLI1 (Thompson et al, 1996) characterised a novel gene EAT2 which was cloned from a mouse cDNA library. EAT2 expression correlated with transformation of NIH3T3 cells by EWS/FLI1chimeric proteins but not by unrelated genes. They identified a homologous sequence in humans mapped to chromosome 1q22 and detected human EAT-2 transcripts in Ewing's sarcoma cell lines by RT-PCR. In a later report (Thompson, 1999) the variant EWS/ETV1 translocation was also shown to upregulate EAT2.
|Bone Cancer (primary)||SH2D1B and Bone Cancer||View Publications||1|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
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Cite this page: Cotterill SJ. SH2D1B (EAT2), Cancer Genetics Web: http://www.cancer-genetics.org/EAT2.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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