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AXIN1; Axis Inhibitor 1

Location: 16p13.3

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Nomenclature (search for AXIN1)

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Medline Search: cancer AND gene AND AXIN1[TI] (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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AXIN1 plays a role in the Wnt signalling pathway which stabilises beta-catenin, coded by the CTNNB1 gene. CTNNB1 is often mutated or overexpressed in hepatocellular carcinoma (HCC). Satoh et al (2000) reported AXIN1 mutations in HCC samples which did not have CTNNB1 mutations (3/4 cell lines and 5/87 primary tumours). They demonstrated that adenovirus mediated gene transfer of wild-type AXINI induced apoptosis in both HCC and colorectal cancer cells which had accumulated beta-catenin due to either APC, CTNNB1 or AXIN1 mutation. This suggests that AXIN1 may have a therapeutic role in tumour suppression in HCC and colorectal cancers.

Satoh S, et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000 Mar;24(3):245-50    Related articles (PubMed)

Medline Search: hepatocellular carcinoma AND (axin OR axin1) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources

CTNNB1 gene (beta catenin)
Hepatocelular Carcinoma Genetics
Hepatocelular Carcinoma : Clinical and Epidemiological Information

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