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  Chromosome 13

Genes Linked with Cancer (41)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 13; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
FGF9 13q11-q12 GAF, FGF-9, SYNS3, HBFG-9, HBGF-9-Bone Cancer (primary)
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
LATS2 13q11-q12 KPM-Lung Cancer
-Mesothelioma
ZMYM2 13q11-q12 FIM, MYM, RAMP, SCLL, ZNF198Somatic
GJB2 13q11-q12 HID, KID, PPK, CX26, DFNA3, DFNB1, NSRD1, DFNA3A, DFNB1A-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Skin Cancer
FLT1 13q12 FLT, FLT-1, VEGFR1, VEGFR-1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
LHFP 13q12 Somatic
KL 13q12 -Breast Cancer
-Lung Cancer
-Multiple Myeloma
-Ovarian Cancer
-Pancreatic Cancer
FLT3 13q12 FLK2, STK1, CD135, FLK-2Somatic-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
HMGB1 13q12 HMG1, HMG3, SBP-1-Breast Cancer
-Eye Cancer
-Liver Cancer
-Prostate Cancer
-Stomach Cancer
IFT88 13q12.1 DAF19, TG737, TTC10, hTg737, D13S1056E-Liver Cancer
PDX1 13q12.1 GSF, IPF1, IUF1, IDX-1, MODY4, PDX-1, STF-1, PAGEN1-Pancreatic Cancer
-Stomach Cancer
CCNA1 13q12.3-q13 CT146-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Head and Neck Cancers
-Lung Cancer
BRCA2 13q12.3 FAD, FACD, FAD1, GLM3, BRCC2, FANCD, PNCA2, FANCD1, BROVCA2Germline & Somatic-Breast Cancer
-Breast Cancer, Familial
-Cancer Screening
-Fanconi Anaemia
-Intraocular (Eye) Melanoma
-Male Breast Cancer
-Ovarian Cancer
-Pancreatic Cancer
CDX2 13q12.3 CDX3, CDX-3, CDX2/ASSomatic-Acute Myeloid Leukaemia
-Cervical Cancer
-Colorectal Cancer
-Pancreatic Cancer
STARD13 13q13.1 DLC2, GT650, ARHGAP37, LINC00464-Astrocytoma, Childhood
-Brain Tumours, Childhood
-Liver Cancer
POSTN 13q13.3 PN, OSF2, OSF-2, PDLPOSTN, periostin-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
TPT1 13q14 HRF, p02, p23, TCTP
TNFSF11 13q14 ODF, OPGL, sOdf, CD254, OPTB2, RANKL, TRANCE, hRANKL2-Bone Cancer (primary)
-Breast Cancer
-Lung Cancer
-Multiple Myeloma
-Prostate Cancer
TSC22D1 13q14 Ptg-2, TSC22, TGFB1I4-Cervical Cancer
-Prostate Cancer
-Salivary Gland Cancer
TRIM13 13q14 CAR, LEU5, RFP2, DLEU5, RNF77-Chronic Lymphocytic Leukemia
-Multiple Myeloma
FOXO1 13q14.1 FKH1, FKHR, FOXO1ASomatic
Translocation
-Childhood Cancers
-Rhabdomyosarcoma
-Skin Cancer
-Urinary System Cancers
RB1 13q14.2 RB, pRb, OSRC, pp110, p105-Rb, PPP1R130Germline & Somatic-Acute Lymphocytic Leukaemia (ALL)
-Bladder Cancer
-Breast Cancer
-Esophageal Cancer
-Lung Cancer
-Osteosarcoma
-Retinoblastoma
ARL11 13q14.2 ARLTS1-Breast Cancer
-Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
-Pancreatic Cancer
-Prostate Cancer
OLFM4 13q14.3 GC1, OLM4, OlfD, GW112, hGC-1, hOLfD, UNQ362, bA209J19.1-Colorectal Cancer
-Pancreatic Cancer
-Stomach Cancer
-Vulvar Cancer
ATP7B 13q14.3 WD, PWD, WC1, WND-Bladder Cancer
-Liver Cancer
-Ovarian Cancer
DLEU2 13q14.3 1B4, DLB2, LEU2, BCMSUN, RFP2OS, MIR15AHG, TRIM13OS, LINC00022, NCRNA00022-Chronic Lymphocytic Leukemia
LCP1 13q14.3 LPL, CP64, PLS2, LC64P, HEL-S-37, L-PLASTINSomatic
EDNRB 13q22 ETB, ET-B, ETBR, ETRB, HSCR, WS4A, ABCDS, ET-BR, HSCR2-Bladder Cancer
-Melanoma
-Oral Cavity Cancer
-Prostate Cancer
-Skin Cancer
-Urinary System Cancers
KLF5 13q22.1 CKLF, IKLF, BTEB2-Acute Myeloid Leukaemia
-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
-Uterine Sarcoma
SPRY2 13q31.1 hSPRY2-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
-Thyroid Cancer
TNFSF13B 13q32-q34 DTL, BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20-Chronic Lymphocytic Leukemia
-Multiple Myeloma
ABCC4 13q32 MRP4, MOATB, MOAT-B-Acute Lymphocytic Leukaemia (ALL)
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
ERCC5 13q33 XPG, UVDR, XPGC, COFS3, ERCM2, ERCC5-201Germline-Breast Cancer
-Lung Cancer
-Uterine Sarcoma
EFNB2 13q33 HTKL, EPLG5, Htk-L, LERK5-Breast Cancer
-Melanoma
-Neuroblastoma
LIG4 13q33-q34 LIG4S-Brain Tumours, Childhood
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
GAS6 13q34 AXSF, AXLLG-Acute Myeloid Leukaemia
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Prostate Cancer
ING1 13q34 p33, p47, p33ING1, p24ING1c, p33ING1b, p47ING1a-Liver Cancer
-Lung Cancer
-Stomach Cancer
LAMP1 13q34 LAMPA, CD107a, LGP120-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Ovarian Cancer
CUL4A 13q34 -Breast Cancer
RAP2A 13q34 KREV, RAP2, K-REV, RbBP-30-Brain Tumours, Childhood
-Colorectal Cancer
-Prostate Cancer
IRS2 13q34 IRS-2-Breast Cancer
-Colorectal Cancer
-Prostate Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 13:

Abnormality Type Gene(s)
del(13q) in Head and Neck CancersDeletion
Loss of Chromosome 13 in MyelomaDeletion
t(1;13)(p36;q14) in RhabdomyosarcomaTranslocationFOXO1 (13q14.1)PAX7 (1p36.13)
t(2;13)(q35;q14) in RhabdomyosarcomaTranslocationFOXO1 (13q14.1)PAX3 (2q35)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

Further Resources


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Cite this page: Cotterill SJ. Chromosome 13, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc13.htm Accessed: date

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