Chromosome 13

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 13; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
ZMYM2 13q11-q12 FIM, MYM, RAMP, SCLL, ZNF198Somatic
FLT1 13q12 FLT, FLT-1, VEGFR1, VEGFR-1
FLT3 13q12 FLK2, STK1, CD135, FLK-2Somatic
LHFP 13q12 Somatic
BRCA2 13q12.3 FAD, FACD, FAD1, GLM3, BRCC2, FANCD, PNCA2, FANCD1, BROVCA2Germline & Somatic-Breast Cancer
-Breast Cancer, Familial
-Cancer Screening
-Fanconi Anaemia
-Intraocular (Eye) Melanoma
-Male Breast Cancer
-Ovarian Cancer
-Pancreatic Cancer
CDX2 13q12.3 CDX3, CDX-3Somatic
TPT1 13q14 HRF, p02, p23, TCTP
FOXO1 13q14.1 FKH1, FKHR, FOXO1ASomatic
RB1 13q14.2 RB, pRb, OSRC, pp110, p105-RbGermline & Somatic
LCP1 13q14.3 LPL, CP64, PLS2, LC64P, HEL-S-37, L-PLASTINSomatic
ERCC5 13q33 XPG, UVDR, XPGC, COFS3, ERCM2Germline
EFNB2 13q33 HTKL, EPLG5, Htk-L, LERK5-Breast Cancer
ING1 13q34 p33, p47, p33ING1, p24ING1c, p33ING1b, p47ING1a
RAP2A 13q34 KREV, RAP2, K-REV, RbBP-30

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 13:

Abnormality Type Gene(s)
del(13q) in Head and Neck CancersDeletion
Loss of Chromosome 13 in MyelomaDeletion
t(1;13)(p36;q14) in RhabdomyosarcomaTranslocationFOXO1 (13q14.1)PAX7 (1p36.13)
t(2;13)(q35;q14) in RhabdomyosarcomaTranslocationFOXO1 (13q14.1)PAX3 (2q35)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.

Further Resources (2 links)


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