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  Chromosome 13

Genes Linked with Cancer (16)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 13; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
LATS2 13q11-q12 KPM-Lung Cancer
-Mesothelioma
ZMYM2 13q11-q12 FIM, MYM, RAMP, SCLL, ZNF198Somatic
FLT1 13q12 FLT, FLT-1, VEGFR1, VEGFR-1-Bladder Cancer
-Bowel Cancer
-Breast Cancer
FLT3 13q12 FLK2, STK1, CD135, FLK-2Somatic
LHFP 13q12 Somatic
BRCA2 13q12.3 FAD, FACD, FAD1, GLM3, BRCC2, FANCD, PNCA2, FANCD1, BROVCA2Germline & Somatic-Breast Cancer
-Breast Cancer, Familial
-Cancer Screening
-Fanconi Anaemia
-Intraocular (Eye) Melanoma
-Male Breast Cancer
-Ovarian Cancer
-Pancreatic Cancer
CDX2 13q12.3 CDX3, CDX-3Somatic
TPT1 13q14 HRF, p02, p23, TCTP
FOXO1 13q14.1 FKH1, FKHR, FOXO1ASomatic
Translocation
-Rhabdomyosarcoma
RB1 13q14.2 RB, pRb, OSRC, pp110, p105-Rb, PPP1R130Germline & Somatic-Acute Lymphocytic Leukaemia (ALL) - adult
-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Osteosarcoma
-Retinoblastoma
LCP1 13q14.3 LPL, CP64, PLS2, LC64P, HEL-S-37, L-PLASTINSomatic
EFNB2 13q33 HTKL, EPLG5, Htk-L, LERK5-Breast Cancer
-Melanoma
-Neuroblastoma
ERCC5 13q33 XPG, UVDR, XPGC, COFS3, ERCM2Germline
GAS6 13q34 AXSF, AXLLG-Lung Cancer
-Prostate Cancer
ING1 13q34 p33, p47, p33ING1, p24ING1c, p33ING1b, p47ING1a-Liver Cancer
-Lung Cancer
-Stomach Cancer
RAP2A 13q34 KREV, RAP2, K-REV, RbBP-30

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 13:

Abnormality Type Gene(s)
del(13q) in Head and Neck CancersDeletion
Loss of Chromosome 13 in MyelomaDeletion
t(1;13)(p36;q14) in RhabdomyosarcomaTranslocationFOXO1 (13q14.1)PAX7 (1p36.13)
t(2;13)(q35;q14) in RhabdomyosarcomaTranslocationFOXO1 (13q14.1)PAX3 (2q35)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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