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  Multiple Myeloma

Mutated Genes and Abnormal Protein Expression (9)
Recurrent Chromosome Abnormalities (3)
Overview of the Molecular Biology of Multiple Myeloma
Cytogenetics of Multiple Myeloma
Loss of Chromosome 13 in Multiple Myeloma
t(11;14)(q13;q32) in Multiple myeloma
Familial Clustering in Multiple Myeloma
Multiple Myeloma: Clinical and Epidemiological Resources
  Mutated Genes and Abnormal Protein Expression
GeneLocationTopics
SDC12p24.1 -SDC1 Expression in Multiple Myeloma
LTA ( TNFB , LT ) 6p21.3 -LTA Polymorphisms and Risk of MGUS and Myeloma
TNF ( TNFA , TNFSF2 , DIF ) 6p21.3 -TNF Polymorphisms and Risk of MGUS and Myeloma
IRF4 ( MUM1 , LSIRF ) 6p25-p23 -t(6;14)(p25;q32) in Multiple Myeloma
IL6 ( IFNB2 ) 7p21 -IL6 Expression in Multiple Myeloma
HGF ( HPTA ) 7q21.1 -HGF Expression in Multiple Myeloma
CCND1 ( D11S287E , Cyclin D , PRAD1 ) 11q13 -CCND1 Amplification and Overexpression in Multiple Myeloma
B2M15q21-q22 -B2M and Multiple Myeloma
CD1916p11.2 -CD19 Expression in Multiple Myeloma

 

  Recurrent Chromosome Abnormalities

t(6;14)(p25;q32) in Multiple Myeloma
Loss of Chromosome 13 in Multiple Myeloma
t(11;14)(q13;q32) in Multiple myeloma
  Overview of the Molecular Biology of Multiple Myeloma

  • Ludwig H, et al. Multiple myeloma: an update on biology and treatment. [Review] Ann Oncol 1999;10 Suppl 6:31-43    Related articles (PubMed)

  • Almeida J, et al. Immunophenotypic and DNA content characteristics of plasma cells in multiple myeloma and monoclonal gammopathy of undetermined significance. [Review] Pathol Biol (Paris) 1999;47(2):119-27    Related articles (PubMed)

  • Smadja NV, et al. Chromosomal analysis in multiple myeloma: cytogenetic evidence of two different diseases. Leukemia 1998;12(6):960-9    Related articles (PubMed)

  • Medline Search: multiple myeloma AND genetics (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Multiple Myeloma Genetics
    Multiple Myeloma : Clinical and Epidemiological Information

     

  •   Cytogenetics of Multiple Myeloma

  • Perez-Simon JA, et al. Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. Blood 1998 May 1;91(9):3366-71    Related articles (PubMed)

  • Smadja NV, et al. Chromosomal analysis in multiple myeloma: cytogenetic evidence of two different diseases. Leukemia 1998;12(6):960-9    Related articles (PubMed)

  • Sawyer JR, et al. Cytogenetic findings in 200 patients with multiple myeloma. Cancer Genet Cytogenet 1995 Jul 1;82(1):41-9    Related articles (PubMed)

  • Medline Search: multiple myeloma AND chromosome abnormalities (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Multiple Myeloma Genetics
    Multiple Myeloma : Clinical and Epidemiological Information

     

  •   Loss of Chromosome 13 in Multiple Myeloma

  • Zojer N, et al. Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization. Multicenter Investigation of Bone Marrow Transplantation for Sickle Cell Disease. Blood 2000 Mar 15;95(6):1925-30    Related articles (PubMed)

  • Avet-Loiseau H, et al. Monosomy 13 is associated with the transition of monoclonal gammopathy of undetermined significance to multiple myeloma. Intergroupe Francophone du Myelome. Blood 1999 Oct 15;94(8):2583-9    Related articles (PubMed)

  • Medline Search: multiple myeloma AND chromosome 13 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Multiple Myeloma Genetics
    Multiple Myeloma : Clinical and Epidemiological Information
    Chromosme 13

     

  •   t(11;14)(q13;q32) in Multiple myeloma

  • Hoyer JD, et al. The (11;14)(q13;q32) translocation in multiple myeloma. A morphologic and immunohistochemical study. Am J Clin Pathol 2000 Jun;113(6):831-7    Related articles (PubMed)

  • Janssen JW, et al. Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32). Blood 2000 Apr 15;95(8):2691-8    Related articles (PubMed)

  • Pruneri G, et al. Immunohistochemical analysis of cyclin D1 shows deregulated expression in multiple myeloma with the t(11;14). Am J Pathol 2000 May;156(5):1505-13    Related articles (PubMed)

  • Avet-Loiseau H, et al. 14q32 translocations and monosomy 13 observed in monoclonal for the oncogenesis of multiple myeloma. Intergroupe Francophone du Myelome. Cancer Res 1999 Sep 15;59(18):4546-50    Related articles (PubMed)

  • Medline Search: multiple myeloma AND translocation AND chromosome 11 AND chromosome 14 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
  • Cyclin D1 Amplification and Overexpression in Multiple Myeloma

  • Chromosme 14

     

  •   Familial Clustering in Multiple Myeloma

    Some studies have shown a modest increased risk of multiple myeloma in people with relatives diagnosed with multiple myeloma or other cancers. It is not clear if this represents hereditary genetic risk factors (as yet unidentified) or common exposure to environmental factors.

  • Brown LM, et al. Multiple myeloma and family history of cancer among blacks and whites in the U.S. Cancer 1999 Jun 1;85(11):2385-90    Related articles (PubMed)

  • Grosbois B, et al. Familial multiple myeloma: report of fifteen families. Br J Haematol 1999 Jun;105(3):768-70    Related articles (PubMed)

  • Eriksson M, Hallberg B Familial occurrence of hematologic malignancies and other diseases in multiple myeloma: a case-control study. Cancer Causes Control 1992 Jan;3(1):63-7    Related articles (PubMed)

  • Loth TS, et al. Genetic aspects of familial multiple myeloma. [Review] Mil Med 1991 Aug;156(8):430-3    Related articles (PubMed)

  • Medline Search: familial multiple myeloma (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Multiple Myeloma Genetics
    Multiple Myeloma : Clinical and Epidemiological Information

     

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