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  Chromosome 4

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 4; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
PHOX2B 4p12 PMX2B, NBLST2, NBPhoxGermline & Somatic
RHOH 4p13 TTF, ARHHSomatic
PCDH7 4p15 BHPCDH, BH-Pcdh
SLC34A2 4p15.2 NPTIIb, NAPI-3B, NAPI-IIbSomatic
Fusion
-Lung Cancer, Non-Small Cell
WHSC1 4p16.3 WHS, NSD2, TRX5, MMSET, REIIBPSomatic
FGFR3 4p16.3 ACH, CEK2, JTK4, CD333, HSFGFR3EXSomatic
KDR 4q11-q12 FLK1, CD309, VEGFR, VEGFR2Somatic
CHIC2 4q11 BTLSomatic
FIP1L1 4q12 Rhe, FIP1, hFip1Somatic
Deletion / Translocation
-Leukaemia
KIT 4q12 PBT, SCFR, C-Kit, CD117Germline & Somatic
PDGFRA 4q12 CD140A, PDGFR2, PDGFR-2, RHEPDGFRASomatic
Deletion / Translocation
-Leukaemia
AFP 4q13.3 FETA, HPAFP
MUC7 4q13.3 MG2
RASSF6 4q13.3
Methylation
-Neuroblastoma
CXCL3 4q21 GRO3, GROg, MIP2B, SCYB3, MIP-2b, CINC-2b
AFF1 4q21 AF4, PBM1, MLLT2Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL) - adult
-Acute Lymphocytic Leukemia (ALL), child
CXCL2 4q21 GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a-Bowel Cancer
-Breast Cancer
EIF4E 4q21-q25 CBP, EIF4F, AUTS19, EIF4E1, EIF4EL1
CXCL1 4q21 FSP, GRO1, GROa, MGSA, NAP-3, SCYB1, MGSA-a-Bowel Cancer
-Breast Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
IBSP 4q21.1 BSP, BNSP, SP-II, BSP-II
ABCG2 4q22 MRX, MXR, ABCP, BCRP, BMDP, MXR1, ABC15, BCRP1, CD338, GOUT1, CDw338, UAQTL1, EST157481
SPP1 4q22.1 OPN, BNSP, BSPI, ETA-1
RAP1GDS1 4q23-q25 GDS1, SmgGDSSomatic
TET2 4q24 MDS, KIAA1546Somatic-Acute Myeloid Leukaemia
-Acute Myeloid Leukaemia (AML) - childhood
-Chronic Myelogenous Leukemia
-Myelodysplastic Syndromes
-Myeloproliferative Disorders
FGF2 4q26 BFGF, FGFB, FGF-2, HBGF-2-Breast Cancer
-Melanoma
-Ovarian Cancer
-Prostate Cancer
IL2 4q26-q27 IL-2, TCGF, lymphokineSomatic
FBXW7 4q31.3 AGO, CDC4, FBW6, FBW7, hAgo, FBX30, FBXW6, SEL10, hCdc4, FBXO30, SEL-10Somatic-Acute Lymphocytic Leukaemia (ALL) - adult
-Acute Lymphocytic Leukemia (ALL), child
-Bowel Cancer
-Breast Cancer
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Wilms Tumour
VEGFC 4q34.3 VRP, Flt4-L
FAT1 4q35 FAT, ME5, CDHF7, CDHR8, hFat1
DUX4 4q35 DUX10Somatic

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 4:

Abnormality Type Gene(s)
FIP1L1-PDGFRA fusion in LeukemiaDeletion / TranslocationPDGFRA (4q12)FIP1L1 (4q12)
SLC34A2-ROS1 Fusion in NSCLCFusionSLC34A2 (4p15.2)ROS1 (6q22)
t(4;11)(q21;q23) in Infant LeukaemiaTranslocationAFF1 (4q21)KMT2A (11q23)
t(4;11)(q21;q23) MLL-AFF1 in adult acute lymphoblastic leukemiaTranslocationAFF1 (4q21)KMT2A (11q23)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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