 Summary Information
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Location: 11q23
Aliases: ALL1, HRX
Overview:
The MLL gene is involved in a large number of different chromosomal translocations resulting in a range of MLL fusion proteins. These different types of translocations tend to be associate with a specific type of leukaemia. For example, the t(9;11)
translocation of the MLL and MLLT4 (AF9) genes is mainly found in acute myeloid leukaemia cells.
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| Gene Database Entries for MLL
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OMIM
GeneCard (Weizmann Institute)
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Genbank
Swiss-Prot
Locus Link
GenAtlas
GDB
Nomenclature (search for MLL)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (MLL[TI] OR ALL1[TI] OR HRX[TI]) (PubMed)
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| MLL and Leukaemia
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Taki T, et al. Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia. Leukemia. 1996; 10(8):1303-7 Related articles (PubMed)
Medline Search: MLL gene AND leukaemia (PubMed)
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- Related Resources
 MLLT2 (AF-4) gene- MLLT3 (AF-9) gene
- MLLT4 (AF-6) gene
- MLLT5 (EPS15) gene
- MLLT6 (AF-17) gene
- MLLT7.htm (AFX1) gene
Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| t(11;19)(q23;p13) in Leukaemia
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Rubnitz JE. et al. Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13.3) translocation. J Clin Oncol 1999; 17:191-6 Related articles (PubMed)
Medline Search: leukemia AND translocation AND chromosome 11 AND chromosome 19 (PubMed)
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- Related Resources
- MLL (ALL1) gene
- MLLT1gene
Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| t(4;11)(q21;q23) in Leukaemia
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Heerema NA. et al. Cytogenetic studies of infant acute lymphoblastic leukemia: poor prognosis of infants with t(4;11) - a report of the Children's Cancer Group. Leukemia 1999;13:679-86 Related articles (PubMed)
Yamamoto S, et al. High frequency of fusion transcripts of exon 11 and exon 4/5 in AF-4 gene is observed in cord blood, as well as leukemic cells from infant leukemia patients with t(4;11)(q21;q23) Leukemia. 1998 Sep;12(9):1398-403 Related articles (PubMed)
Medline Search: leukaemia AND translocation AND chromosome 4 AND chromosome 11 (PubMed)
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- Related Resources
- MLL (ALL1) gene
- MLLT2 (AF4) gene
Childhood Leukaemia Genetics
Childhood Leukaemia : Clinical and Epidemiological Information
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| t(9;11) in Acute Myeloid Leukaemia
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Nakamura T. et al. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc Natl Acad Sci USA. 1993; 90:4631-5 Related articles (PubMed)
Dobson CL. et al. The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. EMBO J 1999; 18:3564-74 Related articles (PubMed)
Medline Search: myeloid leukaemia AND (mml-af9 OR MLL) (PubMed)
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- MLL (ALL1) gene
- MLLT3 (AF-9) gene
Acute Myeloid Leukaemia Genetics
Acute Myeloid Leukaemia : Clinical and Epidemiological Information
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| t(10;11) AF10-MLL translocation in Acute Leukaemia
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Beverloo HB, et al. Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis. Cancer Res 1995; 55(19):4220-4 Related articles (PubMed)
Medline Search: AF10 AND MLL AND leukemia AND translocation (PubMed)
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- MLL gene
- AF10 gene
Leukaemia Genetics
Leukaemia : Clinical and Epidemiological Information
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| ins(5;11)(q31;q13q23) in Acute Lymphoblastic Leukaemia
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Taki T, et al. AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23). Proc Natl Acad Sci USA 1999 7;96(25):14535-40 Related articles (PubMed)
Medline Search: AF5q31 AND leukemia (PubMed)
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Childhood Leukaemia Genetics
Childhood Leukaemia : Clinical and Epidemiological Information
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[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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