 Summary Information
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Location: 4q26-q27
Alias: TCGF
Overview:
Interleukin-2 (IL-2) is the main factor responsible for the proliferation of activated T cells. IL-2 also effects other components of the immune system including
B cells and macrophages. In animal and some humans studies, administration of IL-2 has been shown to have antitumor effects, probably mediated by cytotoxic effector cells (such as lymphokine-activated killer - LAK cells and cytotoxic T lymphocytes). There
are many ongoing cancer clinical trials investigating the use of IL-2 in a variety of settings. Gene therapy approaches transfecting cells with the IL-2 gene are also being investigated.
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| Gene Database Entries for IL2
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OMIM
GeneCard (Weizmann Institute)
Tumor Gene Database
Genbank
Swiss-Prot
Locus Link (search for IL2)
UniGene
GenAtlas
GDB
Nomenclature (search for IL2)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (IL2[TI] OR TCGF[TI]) (PubMed)
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| IL-2
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Reichert TE, et al Interleukin-2 expression in human carcinoma cell lines and its role in cell cycle progression. Oncogene 2000 Jan 27;19(4):514-25 Related articles (PubMed)
Seigel LJ, et al. Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1. Science 1984; 223(4632):175-8 Related articles (PubMed)
Holbrook NJ, et al. DNA sequence of the 5' flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus. Nucleic Acids Res 1984; 12(12):5005-13 Related articles (PubMed)
Lowenthal JW, et al. Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes. Nature 1985; 315(6021):669-72 Related articles (PubMed)
Medline Search: interleukin 2 (PubMed)
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| IL2 in Immuo-chemotherapy
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Frydecka I, et al. Immunotherapy with recombinant human interleukin 2 in patients with hematological malignancies after bone marrow or peripheral blood stem cell transplantation. [Review] Arch Immunol Ther Exp. 1999;47(4):223-7 Related articles (PubMed)
Keilholz U, et al. Recombinant interleukin-2-based treatments for advanced melanoma: the experience of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group. [Review] Cancer J Sci Am. 1997; 3 Suppl 1:S22-8 Related articles (PubMed)
Kolitz JE, Mertelsmann R The immunotherapy of human cancer with interleukin 2: present status and future directions. Cancer Invest 1991; 9(5):529-42 Related articles (PubMed)
Medline Search: (interleukin 2[TI] OR IL-2[TI]) AND cancer AND chemotherapy (PubMed)
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| IL2 in Gene Therapy (Experimental)
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IL2 is a growth factor for cytokine-induced killer cells (also known as natural killer-like T-lymphocytes). These cells have been shown to have antitumour activity.
Ongoing research is exploring how transfecting cells (such as fibroblasts or cytokine-induced killer cells) with the IL-2 gene can be used as a cancer therapy.
Schmidt-Wolf IG, et al. Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma. Br J Cancer. 1999; 81(6):1009-16 Related articles (PubMed)
Sobol RE, et al. Interleukin 2 gene therapy of colorectal carcinoma with autologous irradiated tumor cells and genetically engineered fibroblasts: a Phase I study. Clin Cancer Res 1999; 5(9):2359-65 Related articles (PubMed)
Palmer K, et al. Gene therapy with autologous, interleukin 2-secreting tumor cells in patients with malignant melanoma. Hum Gene Ther 1999; 10(8):1261-8 Related articles (PubMed)
Medline Search: interleukin 2 AND cancer AND gene therapy (PubMed)
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[Home] This page created: 02/12/1999 Last revised: 29/04/2003 © Copyright 1999-
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