|Gene:||FAS; Fas cell surface death receptor|
|Aliases:||APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6|
|Summary:||The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]|
|Databases:||OMIM, HGNC, Ensembl, GeneCard, Gene|
|Protein:||tumor necrosis factor receptor superfamily member 6|
|Source:||NCBIAccessed: 31 August, 2019|
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Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Apoptosis||FAS and Apoptosis in Cancer||View Publications||0|
|-||FAS Polymorphisms and Cancer Susceptibility||View Publications||0|
|Urinary System Cancers||FAS and Urinary System Cancers||View Publications||0|
|Breast Cancer||FAS and Breast Cancer||View Publications||0|
|Lung Cancer||FAS and Lung Cancer||View Publications||0|
|Skin Cancer||FAS and Skin Cancer||View Publications||0|
|Stomach Cancer||FAS and Stomach Cancer||View Publications||0|
|Cervical Cancer||FAS and Cervical Cancer||View Publications||0|
|Acute Lymphocytic Leukaemia (ALL)||FAS and Acute Lymphoblastic Leukaemia||View Publications||0|
|Melanoma||FAS and Melanoma||View Publications||0|
|Bladder Cancer||FAS and Bladder Cancer||View Publications||0|
|Thyroid Cancer||FAS and Thyroid Cancer||View Publications||0|
|Multiple Myeloma||FAS and Multiple Myeloma||View Publications||0|
|Testicular Cancer||FAS and Testicular Cancer||View Publications||0|
|Rectal Cancer||FAS and Rectal Cancer||View Publications||0|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.
Cite this page: Cotterill SJ. TNFRSF6, Cancer Genetics Web: http://www.cancer-genetics.org/TNFRSF6.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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[Home] Page last revised: 31 August, 2019 Cancer Genetics Web, Established 1999