www.Cancer-Genetics.org
Navigate
  Chromosome 14

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 14; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
TRD 14q11.2 TCRD, TRD@, TCRDV1Somatic
TEP1 14q11.2 TP1, TLP1, p240, TROVE1, VAULT2-Bladder Cancer
-Breast Cancer
-Cervical Cancer
CCNB1IP1 14q11.2 HEI10, C14orf18Somatic
TRA 14q11.2 IMD7, TCRA, TCRD, TRA@, TRACSomatic
MMP14 14q11.2 MMP-14, MMP-X1, MT-MMP, MT1MMP, MTMMP1, WNCHRS, MT1-MMP, MT-MMP 1
BCL2L2 14q11.2-q12 BCLW, BCL-W, PPP1R51, BCL2-L-2
SSTR1 14q13 SS1R, SS1-R, SRIF-2, SS-1-R
FOXG1 14q13 BF1, BF2, QIN, FKH2, HBF2, HFK1, HFK2, HFK3, KHL2, FHKL3, FKHL1, FKHL2, FKHL3, FKHL4, HBF-1, HBF-2, HBF-3, FOXG1A, FOXG1B, FOXG1C, HBF-G2
NKX2-1 14q13 BCH, BHC, NK-2, TEBP, TTF1, NKX2A, TITF1, TTF-1, NKX2.1Somatic
FANCM 14q21.2 FAAP250, KIAA1596Germline-Fanconi Anaemia
NEMF 14q22 NY-CO-1, SDCCAG1
NIN 14q22.1 SCKL7Somatic
KTN1 14q22.1 CG1, KNT, MU-RMS-40.19Somatic
RAD51B 14q23-q24.2 REC2, R51H2, RAD51L1Somatic
MAX 14q23 bHLHd4
ESR2 14q23.2 Erb, ESRB, ESTRB, NR3A2, ER-BETA, ESR-BETA
HIF1A 14q23.2 HIF1, MOP1, PASD8, HIF-1A, bHLHe78, HIF-1alpha, HIF1-ALPHA-Breast Cancer
-Kidney Cancer
-Lung Cancer
-Prostate Cancer
-Thyroid Cancer
-Urinary System Cancers
GPHN 14q23.3 GPH, GEPH, HKPX1, GPHRYN, MOCODCSomatic
FOS 14q24.3 p55, AP-1, C-FOS
TRIP11 14q31-q32 ACG1A, CEV14, TRIP-11, TRIP230, GMAP-210Somatic
TSHR 14q31 LGR3, CHNG1, hTSHR-IGermline & Somatic
FOXN3 14q31.3 CHES1, PRO1635, C14orf116
TCL6 14q32.1 TNG1, TNG2Somatic
TCL1A 14q32.1 TCL1Somatic
GOLGA5 14q32.12 RFG5, GOLIM5, ret-IISomatic
DICER1 14q32.13 DCR1, MNG1, Dicer, HERNA, RMSE2Germline & Somatic
BCL11B 14q32.2 ATL1, RIT1, CTIP2, CTIP-2, ZNF856B, ATL1-beta, ATL1-alpha, ATL1-delta, ATL1-gamma, hRIT1-alphaSomatic
AKT1 14q32.32 AKT, PKB, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHASomatic-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Skin Cancer
-Soft Tissue Sarcoma
IGH 14q32.33 IGD1, IGH@, IGHJ, IGHV, IGHD@, IGHJ@, IGHV@, IGH.1@, IGHDY1Somatic
Translocation
-Lymphoma
-Multiple Myeloma
-Non-Hodgkin Lymphoma
HSP90AA1 14q32.33 EL52, HSPN, LAP2, HSP86, HSPC1, HSPCA, Hsp89, Hsp90, HSP89A, HSP90A, HSP90N, HSPCAL1, HSPCAL4Somatic

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 14:

Abnormality Type Gene(s)
add(14q32) / dup(14p32) in Non-Hodgkin's LymphomaAdd
14q Deletions in Mesothelioma (14q11-q12 and 14q23-q24)Deletion
14q Deletions in NeuroblastomaDeletion
t(11;14)(q13;q32) in Mantle Cell LymphomaTranslocation
t(11;14)(q13;q32) in MyelomaTranslocation
t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt's lymphomaTranslocation
t(8;14)(q11.2;q32) in Childhood ALL (Down's associated)Translocation
t(14;18)(q32;q21) in Acute Lymphoblastic LeukaemiaTranslocation
t(14;18)(q32;q21) in Non-Hodgkin's LymphomaTranslocation
t(3;14)(q27;q32) in B-cell non-Hodgkin's lymphomaTranslocation
t(1;14)(q21;q32) BCL9/IGHTranslocationIGH (14q32.33)BCL9 (1q21)
t(1;14)(q21;q32) and MUC1 Overexpression in NHLTranslocationIGH (14q32.33)MUC1 (1q21)
t(6;14)(p25,q32) in LymphomasTranslocationIGH (14q32.33)IRF4 (6p25-p23)
t(6;14)(p25;q32) in MyelomaTranslocationIGH (14q32.33)IRF4 (6p25-p23)
t(11;14)(p15;q11) and LMO1 in T-ALLTranslocation
t(9;14)(p13;q32) in LymphomaTranslocation
t(1;14)(p22;q32) in MALT B cell lymphomaTranslocation

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)


Contents

Found this page useful?

Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.

 [Home]    Page last revised: 12 July, 2014     © Copyright 1999-