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  Chromosome 14

Genes Linked with Cancer (59)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 14; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
SCFV 14 -Breast Cancer
-Multiple Myeloma
-Neuroblastoma
GZMB 14q11.2 HLP, CCPI, CGL1, CSPB, SECT, CGL-1, CSP-B, CTLA1, CTSGL1-Cervical Cancer
-Waldenstrom's Macroglobulinemia
TRD 14q11.2 TCRD, TRD@, TCRDV1Somatic-Lung Cancer
APEX1 14q11.2 APE, APX, APE1, APEN, APEX, HAP1, REF1-Cervical Cancer
-Skin Cancer
-Stomach Cancer
-Thyroid Cancer
BCL2L2 14q11.2-q12 BCLW, BCL-W, PPP1R51, BCL2-L-2-Colorectal Cancer
-Liver Cancer
CEBPE 14q11.2 CRP1, C/EBP-epsilon-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
NDRG2 14q11.2 SYLD-Brain Tumours, Childhood
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
-Prostate Cancer
-Skin Cancer
TEP1 14q11.2 TP1, TLP1, p240, TROVE1, VAULT2-Bladder Cancer
-Breast Cancer
-Cervical Cancer
IRF9 14q11.2 p48, IRF-9, ISGF3, ISGF3G-Bladder Cancer
-Liver Cancer
-Melanoma
-Skin Cancer
CCNB1IP1 14q11.2 HEI10, C14orf18Somatic-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Rectal Cancer
MMP14 14q11.2 MMP-14, MMP-X1, MT-MMP, MT1MMP, MTMMP1, WNCHRS, MT1-MMP, MT-MMP 1-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Stomach Cancer
TRA 14q11.2 IMD7, TCRA, TCRD, TRA@, TRACSomatic-Breast Cancer
-Childhood Cancers
-Chronic Myelogenous Leukemia
-Colorectal Cancer
-Lung Cancer
-Uterine Sarcoma
FOXA1 14q12-q13 HNF3A, TCF3A-Breast Cancer
-Prostate Cancer
NKX2-1 14q13 BCH, BHC, NK-2, TEBP, TTF1, NKX2A, T/EBP, TITF1, TTF-1, NKX2.1Somatic-Lung Cancer
-Lung Cancer, Non-Small Cell
-Thyroid Cancer
SSTR1 14q13 SS1R, SS1-R, SRIF-2, SS-1-R-Breast Cancer
-Carcinoid Tumours
-Lung Cancer
-Neuroblastoma
-Pancreatic Cancer
-Pituitary Tumors
-Prostate Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
-Thyroid Cancer
FOXG1 14q13 BF1, BF2, QIN, FKH2, HBF2, HFK1, HFK2, HFK3, KHL2, FHKL3, FKHL1, FKHL2, FKHL3, FKHL4, HBF-1, HBF-2, HBF-3, FOXG1A, FOXG1B, FOXG1C, HBF-G2-Brain Tumours, Childhood
-Childhood Cancers
-Prostate Cancer
-Wilms Tumour
NFKBIA 14q13 IKBA, MAD-3, NFKBI-Brain Tumours, Childhood
-Colorectal Cancer
-Hodgkin Lymphoma
-Lung Cancer
EGLN3 14q13.1 PHD3, HIFPH3, HIFP4H3-Adrenocortical Cancer
-Breast Cancer
-Kidney Cancer
-Pheochromocytoma and Paraganglioma
-von Hippel-Lindau Disease
-Waldenstrom's Macroglobulinemia
PNN 14q21.1 DRS, DRSP, SDK3, memA-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Bladder Cancer
-Breast Cancer
-Leukaemia
-Melanoma
-Neuroblastoma
-Rhabdomyosarcoma
FANCM 14q21.2 FAAP250, KIAA1596Germline-Fanconi Anaemia
BMP4 14q22-q23 ZYME, BMP2B, OFC11, BMP2B1, MCOPS6-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Skin Cancer
PTGER2 14q22 EP2-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
NEMF 14q22 NY-CO-1, SDCCAG1-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
KTN1 14q22.1 CG1, KNT, MU-RMS-40.19Somatic-Bone Cancer (primary)
-Liver Cancer
-Thyroid Cancer
NIN 14q22.1 SCKL7Somatic-Stomach Cancer
LGALS3 14q22.3 L31, GAL3, MAC2, CBP35, GALBP, GALIG, LGALS2-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Pheochromocytoma and Paraganglioma
-Stomach Cancer
OTX2 14q22.3 CPHD6, MCOPS5-Brain Tumours, Childhood
-Medulloblastoma
MAX 14q23 bHLHd4-Adrenocortical Cancer
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pheochromocytoma and Paraganglioma
RAD51B 14q23-q24.2 REC2, R51H2, RAD51L1Somatic-Breast Cancer
-Uterine Sarcoma
ARID4A 14q23.1 RBP1, RBBP1, RBP-1, RBBP-1-Breast Cancer
SIX1 14q23.1 BOS3, TIP39, DFNA23-Breast Cancer
-Cervical Cancer
-Wilms Tumour
ESR2 14q23.2 Erb, ESRB, ESTRB, NR3A2, ER-BETA, ESR-BETA-Breast Cancer
-Colorectal Cancer
-Endometrial Cancer
-Ovarian Cancer
-Prostate Cancer
-Uterine Sarcoma
HIF1A 14q23.2 HIF1, MOP1, PASD8, HIF-1A, bHLHe78, HIF-1alpha, HIF1-ALPHA-Breast Cancer
-Kidney Cancer
-Lung Cancer
-Pheochromocytoma and Paraganglioma
-Prostate Cancer
-Thyroid Cancer
-Urinary System Cancers
GPHN 14q23.3 GPH, GEPH, HKPX1, GPHRYN, MOCODCSomatic-Lung Cancer
MTHFD1 14q24 MTHFC, MTHFD-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Head and Neck Cancers
-Ovarian Cancer
TGFB3 14q24 ARVD, RNHF, ARVD1, TGF-beta3-Breast Cancer
-Uterine Sarcoma
GPX2 14q24.1 GPRP, GPx-2, GI-GPx, GPRP-2, GPx-GI, GSHPx-2, GSHPX-GI-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Prostate Cancer
-Wilms Tumour
MLH3 14q24.3 HNPCC7-Colorectal Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
-Stomach Cancer
NUMB 14q24.3 S171, C14orf41, c14_5527-Bladder Cancer
-Brain Stem Glioma, Childhood
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
FOS 14q24.3 p55, AP-1, C-FOS-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Osteosarcoma
-Prostate Cancer
-Rhabdomyosarcoma
-Stomach Cancer
TSHR 14q31 LGR3, CHNG1, hTSHR-IGermline & Somatic
TRIP11 14q31-q32 ACG1A, CEV14, TRIP-11, TRIP230, GMAP-210Somatic
FOXN3 14q31.3 CHES1, PRO1635, C14orf116
DLK1 14q32 DLK, FA1, ZOG, pG2, DLK-1, PREF1, Delta1, Pref-1-Liver Cancer
-Neuroblastoma
-Pituitary Tumors
JAG2 14q32 HJ2, SER2-Breast Cancer
-Lung Cancer
-Multiple Myeloma
-Stomach Cancer
CHGA 14q32 CGA-Lung Cancer
-Lung Cancer, Non-Small Cell
-Neuroblastoma
-Pancreatic Cancer
-Pheochromocytoma and Paraganglioma
-Pituitary Tumors
-Prostate Cancer
-von Hippel-Lindau Disease
MEG3 14q32 GTL2, FP504, prebp1, PRO0518, PRO2160, LINC00023, NCRNA00023-Bladder Cancer
-Cervical Cancer
-Kidney Cancer
-Liver Cancer
-Pituitary Tumors
TCL6 14q32.1 TNG1, TNG2Somatic-Chronic Lymphocytic Leukemia
-Leukaemia
TCL1A 14q32.1 TCL1Somatic-Chronic Lymphocytic Leukemia
-Leukaemia
GOLGA5 14q32.12 RFG5, GOLIM5, ret-IISomatic-Childhood Cancers
-Colorectal Cancer
-Liver Cancer
-Thyroid Cancer
DICER1 14q32.13 DCR1, MNG1, Dicer, HERNA, RMSE2, Dicer1e, K12H4.8-LIKEGermline & Somatic-Childhood Cancers
-Eye Cancer
-Lung Cancer
-Small Cell Lung Cancer
-Ovarian Cancer
-Skin Cancer
-Stomach Cancer
-Testicular Cancer
-Wilms Tumour
BCL11B 14q32.2 ATL1, RIT1, CTIP2, CTIP-2, ZNF856B, ATL1-beta, ATL1-alpha, ATL1-delta, ATL1-gamma, hRIT1-alphaSomatic-Acute Myeloid Leukaemia
-Childhood Cancers
-Chronic Lymphocytic Leukemia
-Leukaemia
XRCC3 14q32.3 CMM6-Breast Cancer
-Colorectal Cancer
-Head and Neck Cancers
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
MTA1 14q32.3 -Breast Cancer
-Cervical Cancer
-Stomach Cancer
WARS 14q32.31 IFI53, IFP53, GAMMA-2-Acute Myeloid Leukaemia
-Breast Cancer
-Chronic Myelogenous Leukemia
-Lung Cancer
TRAF3 14q32.32 CAP1, LAP1, CAP-1, CRAF1, IIAE5, CD40bp-Hodgkin Lymphoma
-Multiple Myeloma
AKT1 14q32.32 AKT, PKB, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHASomatic-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Skin Cancer
-Soft Tissue Sarcoma
IGH 14q32.33 IGD1, IGH@, IGHJ, IGHV, IGHD@, IGHJ@, IGHV@, IGH.1@, IGHDY1Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Childhood Cancers
-Chronic Lymphocytic Leukemia
-Lymphoma
-Mantle-Cell Lymphoma
-Multiple Myeloma
-Non-Hodgkin Lymphoma
-Waldenstrom's Macroglobulinemia
HSP90AA1 14q32.33 EL52, HSPN, LAP2, HSP86, HSPC1, HSPCA, Hsp89, Hsp90, LAP-2, HSP89A, HSP90A, HSP90N, HSPCAL1, HSPCAL4Somatic-Acute Myeloid Leukaemia
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Ovarian Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 14:

Abnormality Type Gene(s)
add(14q32) / dup(14p32) in Non-Hodgkin's LymphomaAdd
14q Deletions in Mesothelioma (14q11-q12 and 14q23-q24)Deletion
14q Deletions in NeuroblastomaDeletion
t(11;14)(q13;q32) in MyelomaTranslocation
t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt's lymphomaTranslocation
t(8;14)(q11.2;q32) in Childhood ALL (Down's associated)Translocation
t(11;14)(q13;q32) in Mantle Cell LymphomaTranslocationIGH (14q32.33)CCND1 (11q13)
t(14;18)(q32;q21) in Acute Lymphoblastic LeukaemiaTranslocation
t(14;18)(q32;q21) in Non-Hodgkin's LymphomaTranslocation
t(3;14)(q27;q32) in B-cell non-Hodgkin's lymphomaTranslocation
t(1;14)(q21;q32) BCL9/IGHTranslocationIGH (14q32.33)BCL9 (1q21)
t(11;14)(q23;q32) IGH-DDX6 Translocations in Hematologic CancersTranslocationIGH (14q32.33)DDX6 (11q23.3)
t(1;14)(q21;q32) and MUC1 Overexpression in NHLTranslocationIGH (14q32.33)MUC1 (1q21)
t(6;14)(p25,q32) in LymphomasTranslocationIGH (14q32.33)IRF4 (6p25-p23)
t(6;14)(p25;q32) in MyelomaTranslocationIGH (14q32.33)IRF4 (6p25-p23)
t(11;14)(p15;q11) and LMO1 in T-ALLTranslocation
t(9;14)(p13;q32) in LymphomaTranslocation
t(1;14)(p22;q32) in MALT B cell lymphomaTranslocation

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

Further Resources


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Cite this page: Cotterill SJ. Chromosome 14, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc14.htm Accessed: date

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