Gene Summary

Gene:TRAF3; TNF receptor associated factor 3
Aliases: CAP1, LAP1, CAP-1, CRAF1, IIAE5, CD40bp
Summary:The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]
Databases:VEGA, OMIM, HGNC, Ensembl, GeneCard, Gene
Protein:TNF receptor-associated factor 3
Source:NCBIAccessed: 11 March, 2017


What does this gene/protein do?
Show (29)
Pathways:What pathways are this gene/protein implicaed in?
Show (3)

Cancer Overview

Research Indicators

Publications Per Year (1992-2017)
Graph generated 11 March 2017 using data from PubMed using criteria.

Literature Analysis

Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.

  • TNF Receptor-Associated Factor 2
  • Gene Deletion
  • Chromosome 14
  • raf Kinases
  • Mutation
  • Cancer Gene Expression Regulation
  • Gene Expression Profiling
  • Oligonucleotide Array Sequence Analysis
  • Proto-Oncogene Proteins
  • Genetic Predisposition
  • Enzyme Activation
  • Transcription Factors
  • Inhibitor of Apoptosis Proteins
  • siRNA
  • TNF Receptor-Associated Factor 1
  • B-Cell Lymphoma
  • Neoplasm Proteins
  • Transfection
  • Cell Transformation, Viral
  • Disease Models, Animal
  • TNF Receptor-Associated Factor 3
  • Genotype
  • Western Blotting
  • B-Lymphocytes
  • TNF Receptor-Associated Factor 6
  • Cell Proliferation
  • beta Catenin
  • ras Proteins
  • Tandem Mass Spectrometry
  • CD40
  • Signal Transduction
  • Proteins
  • Single Nucleotide Polymorphism
  • Protein-Serine-Threonine Kinases
  • Antineoplastic Agents
  • Apoptosis
  • Viral Matrix Proteins
  • Multiple Myeloma
  • NF-kappa B
  • Hodgkin Lymphoma
Tag cloud generated 11 March, 2017 using data from PubMed, MeSH and CancerIndex

Specific Cancers (3)

Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.

Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).

Latest Publications: TRAF3 (cancer-related)

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Cite this page: Cotterill SJ. TRAF3, Cancer Genetics Web: Accessed:

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This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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