|Gene:||TRAF3; TNF receptor associated factor 3|
|Aliases:||CAP1, LAP1, CAP-1, CRAF1, IIAE5, CD40bp|
|Summary:||The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]|
|Databases:||VEGA, OMIM, HGNC, Ensembl, GeneCard, Gene|
|Protein:||TNF receptor-associated factor 3|
|Source:||NCBIAccessed: 11 March, 2017|
What does this gene/protein do?
|Pathways:||What pathways are this gene/protein implicaed in?|
Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.
Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Multiple Myeloma||TRAF3 and Multiple Myeloma||View Publications||13|
|Hodgkin Lymphoma||TRAF3 and Hodgkin Lymphoma||View Publications||4|
|-||TRAF3 and Splenic Neoplasms||View Publications||3|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
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Cite this page: Cotterill SJ. TRAF3, Cancer Genetics Web: http://www.cancer-genetics.org/TRAF3.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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