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  Childhood Leukaemia

Mutated Genes and Abnormal Protein Expression (19)
Recurrent Chromosome Abnormalities (7)
Overview of the Microbiology of Childhood Leukaemias
Childhood Acute Lymphoblastic Leukaemia
Infant Leukaemia
t(1;22) (p13;q13) in Acute Megakaryocytic Leukemia
t(8;14)(q11.2;q32) in Childhood ALL (Down's associated)
Trisomy 21 / Chromosome 21 Mutations in Childhood Leukaemia
Increased Risk of Childhood Leukaemia in Down Syndome
Childhood Leukaemia: Clinical and Epidemiological Resources
  Mutated Genes and Abnormal Protein Expression
GeneLocationTopics
GSTM1 ( GST1 , MU ) 1p13.3 -GSTM1 and Childhood Leukaemia
PBX11q23 -t(1;19)(q23;p13.3) in pre-B-cell ALL
TPMT6p22.3 -TPMT Expression in Childhood Acute Lymphocytic Leukaemia
ZNFN1A17p13-p11.1 -ZNFN1A1 and Childhood Leukaemia
TCRG ( TRG ) 7p15-p14 -TCRG and Childhood Precursor-B cell ALL
PGY1 ( MDR1 , P-gp ) 7q21.1 -MDR1 Expression in Childhood Leukaemia
TCRB ( TRB ) 7q35 -TCRB and Childhood Precursor-B cell ALL
ABL1 ( ABL , JTK7 ) 9q34.1 -Philadelphia Chromosome in Childhood A.L.L.
WT111p13 -WT1 and Childhood Leukaemia
MLL ( ALL1 , HRX ) 11q23 -t(4;11)(q21;q23) in Leukaemia
ETV6 ( TEL ) 12p13 -t(12;21) in Childhood Acute Lymphoblastic Leukaemia
FLT3 ( STK1 , CD135 ) 13q12 -FLT3 and Childhood Leukaemia
TCRD ( TRD ) 14q11.2 -TCRD and Childhood Precursor-B cell ALL
CYP1A1 ( CYP1 ) 15q22-q24 -CYP1A1 and Childhood Leukaemia
MRP ( MRP1 , ABCC1 ) 16p13.1 -MRP1 Expression in Childhood Leukaemia
LRP ( MVP ) 16p13.1-p11.2 -LRP Expression in Childhood Leukaemia
TP53 ( p53 , P53 ) 17p13.1 -TP53 and Childhood Leukaemia
CBFA2 ( AML1 , PEBP2A2 , RUNX1 ) 21q22.3 -t(12;21) in Childhood Acute Lymphoblastic Leukaemia
BCR ( BCR1 , D22S11 ) 22q11 -Philadelphia Chromosome in Childhood A.L.L.

 

  Recurrent Chromosome Abnormalities

ins(5;11)(q31;q13q23) in Acute Lymphoblastic Leukaemia
t(12;21) in Childhood Acute Lymphoblastic Leukaemia
t(4;11)(q21;q23) in Leukaemia
t(1;19)(q23;p13.3) in pre-B-cell ALL
t(1;22) (p13;q13) in Acute Megakaryocytic Leukemia
t(8;14)(q11.2;q32) in Childhood ALL (Down's associated)
Trisomy 21 / Chromosome 21 Mutations in Childhood Leukaemia
  Overview of the Microbiology of Childhood Leukaemias

  • Greaves M Molecular genetics, natural history and the demise of childhood leukaemia. [Review] Eur J Cancer 1999;35(2):173-85    Related articles (PubMed)

  • Martinez-Climent JA, Garcia-Conde J Chromosomal rearrangements in childhood acute myeloid leukemia and myelodysplastic syndromes.[Review] J Pediatr Hematol Oncol 1999; 21(2):91-102    Related articles (PubMed)

  • Medline Search: childhood leukemia AND genetics (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Childhood Leukaemia Genetics
    Childhood Leukaemia : Clinical and Epidemiological Information

     

  •   Childhood Acute Lymphoblastic Leukaemia

  • Ma SK, et al. Cytogenetics and molecular genetics of childhood leukemia. [Review] Hematol Oncol 1999 Sep;17(3):91-105    Related articles (PubMed)

  • Heerema NA, et al. Prognostic Impact of Trisomies of Chromosomes 10, 17, and 5 Among Children With Acute Lymphoblastic Leukemia and High Hyperdiploidy (> 50 Chromosomes). J Clin Oncol 2000 May 9;18(9):1876-1887    Related articles (PubMed)

  • Heerema NA, et al. Association of chromosome arm 9p abnormalities with adverse risk in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group. Blood. 1999; 94(5):1537-44    Related articles (PubMed)

  • Findley HW, et al. Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia. Blood 1997; 89(8):2986-93    Related articles (PubMed)

  • Kobayashi H. et al. Detection of the Der (21)t(12;21) chromosome forming the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia. (Review) Leuk Lymphoma 1997; 28:43-50    Related articles (PubMed)

  • Beltinger C, et al. CD95 (APO-1/Fas) mutations in childhood T-lineage acute lymphoblastic leukemia Blood. 1998; 91(10):3943-51    Related articles (PubMed)

  • Nowak-Gottl U, et al. Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors. Blood 1999; 93(5):1595-9    Related articles (PubMed)

  • Dorak MT, et al. Unravelling an HLA-DR association in childhood acute lymphoblastic leukemia. Blood. 1999; 94(2):694-700    Related articles (PubMed)

  • Medline Search: childhood leukemia AND genetics (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Childhood Leukaemia Genetics
    Childhood Leukaemia : Clinical and Epidemiological Information

     

  •   Infant Leukaemia

    Infants with acute lymphoblastic leukaemia and acute myeloid leukaemia have a high incidence of translocations involving the MLL gene on chromosome 11. The t(4;11) translocation is the most common translocation in infant ALL, and is associated with a poorer prognosis. Absence of CD10 expression has also been reported to be associated with poor prognosis in infant ALL. Alterations of ikaros (ZNFN1A1) are also seen in infant ALL. Some forms of myeloid leukaemia in infants present as myelodysplastic and myeloproliferative syndromes, which can be associated with other constitutional disorders.

  • Hilden JM, et al. Molecular analysis of infant acute leukemia. Leuk Lymphoma 1997; 25(3-4):191-9    Related articles (PubMed)

  • Taki T, et al. Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia. Leukemia. 1996; 10(8):1303-7    Related articles (PubMed)

  • Heerema NA. et al. Cytogenetic studies of infant acute lymphoblastic leukemia: poor prognosis of infants with t(4;11) - a report of the Children's Cancer Group. Leukemia 1999;13:679-86    Related articles (PubMed)

  • Sun L, et al. Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1999 ;96(2):680-5    Related articles (PubMed)

  • Medline Search: infant AND leukemia AND genetics (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Childhood Leukaemia Genetics
    Childhood Leukaemia : Clinical and Epidemiological Information

     

  •   t(1;22) (p13;q13) in Acute Megakaryocytic Leukemia

  • Bernstein J, et al. Nineteen cases of the t(1;22)(p13;q13) acute megakaryblastic leukaemia of infants/children and a review of 39 cases: report from a t(1;22) study group. [Review] Leukemia. 2000; 14(1):216-8    Related articles (PubMed)

  • Lion T, Haas OA Acute megakaryocytic leukemia with the t(1;22)(p13;q13). [Review] Leuk Lymphoma 1993; 11(1-2):15-20    Related articles (PubMed)

  • Carroll A, et al. The t(1;22) (p13;q13) is nonrandom and restricted to infants with acute megakaryoblastic leukemia: a Pediatric Oncology Group Study. Blood. 1991; 78(3):748-52    Related articles (PubMed)

    Childhood Leukaemia Genetics
    Childhood Leukaemia : Clinical and Epidemiological Information
    Chromosme 1
    Chromosme 22

     

  •   t(8;14)(q11.2;q32) in Childhood ALL (Down's associated)

  • Kaleem Z, et al. Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group Study. Leukemia 2000 Feb;14(2):238-40    Related articles (PubMed)

  • Secker-Walker LM, et al. Two Down syndrome patients with an acquired translocation, t(8;14)(q11;q32), in early B-lineage acute lymphoblastic leukemia. Cancer Genet Cytogenet 1993 Oct 15;70(2):148-50    Related articles (PubMed)

  • Medline Search: childhood leukaemia AND t(8;14) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Childhood Leukaemia Genetics
    Childhood Leukaemia : Clinical and Epidemiological Information
    Chromosme 8
    Chromosme 14

     

  •   Trisomy 21 / Chromosome 21 Mutations in Childhood Leukaemia

  • Berger R Acute lymphoblastic leukemia and chromosome 21. [Review] Cancer Genet Cytogenet 1997 Mar;94(1):8-12    Related articles (PubMed)

  • Loncarevic IF, et al. Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion. Genes Chromosomes Cancer 1999 Mar;24(3):272-7    Related articles (PubMed)

  • Medline Search: childhood leukemia AND chromosome 21 (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
  • Down Syndrome (OMIM)

  • Chromosme 21

     

  •   Increased Risk of Childhood Leukaemia in Down Syndome

  • Hasle H, et al. Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet 2000 Jan 15;355(9199):165-9    Related articles (PubMed)

  • Fong CT, Brodeur GM Down's syndrome and leukemia: epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis. Cancer Genet Cytogenet 1987 Sep;28(1):55-76    Related articles (PubMed)

  • Medline Search: childhood leukemia AND Down's syndrome (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

    Related Resources
  • Down Syndrome (OMIM)
  • National Down Syndrome Society (USA)
  • Down Syndrome Information Network (UK)
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