Renal Cell Carcinoma - Genetics

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Renal Cell Carcinoma
Mutated Genes and Abnormal Protein Expression (10) Recurrent Chromosome Abnormalities (2) Molecular biology of Renal Cancer Hereditary Papillary Renal Cell Carcinoma Renal Cell Carcinoma: Clinical and Epidemiological Resources

Mutated Genes and Abnormal Protein Expression
Gene	Location	Topics
PRCC ( RCCP1 )	1q21	-t(X;1)(p11;q21) in Papillary Renal Cell Carcinoma
RCA1 ( HRCA1 , TRC8 )	3p14.2-3p14.2	-t(3;8)(p14.2;q24.1) in Hereditary Renal Cell Carcinoma
VHL	3p26-p25	-VHL and Renal Cell Carcinoma
IL6 ( IFNB2 )	7p21	-IL-6 Expression in Renal Cell Carcinoma
HGF ( HPTA )	7q21.1	-HGF and Renal Cell Carcinoma
MET ( HGFR , c-met )	7q31	-MET and Renal Cell Carcinoma -MET and Hereditary Papillary Renal Carcinoma
TSC1 ( TSC , KIAA0243 )	9q34	-TSC1 and Renal Cell Carcinoma ?
TSC2 ( TSC4 )	16p13.3	-TSC2 and Renal Cell Carcinoma ?
CA9 ( NM )	17q21.2	-CA9 Expression in Renal Cell Carcinoma
TFE3	Xp11.22	-TFE3 and Papillary Renal Cell Carcinoma -t(X;1)(p11;q21) in Papillary Renal Cell Carcinoma

Recurrent Chromosome Abnormalities
t(3;8)(p14.2;q24.1) in Hereditary Renal Cell Carcinoma t(X;1)(p11;q21) in Papillary Renal Cell Carcinoma Related links: Recurrent Chromosome Abnormalities - Kidney (Cancer Genome Anatomy Project)

Molecular biology of Renal Cancer
Fleming S Renal cancer genetics: von Hippel Lindau and other syndromes. [Review] Int J Dev Biol 1999;43(5 Spec No):469-71 Related articles (PubMed) Wang L, et al. Loss of expression of the DRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma. Genes Chromosomes Cancer 2000;27(1):1-10 Related articles (PubMed) van Kessel AG, et al. Renal cell cancer: chromosome 3 translocations as risk factors. J Natl Cancer Inst 1999; 91(13):1159-60 Related articles (PubMed) Gemmill RM, et al. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. Proc Natl Acad Sci USA 1998 Aug 4;95(16):9572-7 Related articles (PubMed) Zbar B, et al. Inherited carcinomas of the kidney. [Review] Adv Cancer Res. 1998;75:163-201 Related articles (PubMed) *Medline Search:* renal cell cancer AND genetics (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Renal Cell Carcinoma Genetics Renal Cell Carcinoma : Clinical and Epidemiological Information
Hereditary Papillary Renal Cell Carcinoma
Zhuang Z, et al. Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas. Nat Genet. 1998; 20(1):66-9 Related articles (PubMed) Fischer J, et al. Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours. Oncogene. 1998; 17(6):733-9. Related articles (PubMed) Lubensky IA, et al. Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype. Am J Pathol 1999;155(2):517-26 Related articles (PubMed) *Medline Search:* hereditary papillary renal cell carcinoma (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Renal Cell Carcinoma Genetics Renal Cell Carcinoma : Clinical and Epidemiological Information
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