 Summary Information
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Location: 11p15.5
Overview:
The loss of imprinting of insulin-like growth factor 2 (IGF2) and an overdosage of this growth factor gene have been reported in a wide range of cancers, particularly in Wilms' tumour.
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| Gene Database Entries for IGF2
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OMIM
GeneCard (Weizmann Institute)
Genbank
Swiss-Prot
Locus Link (search for IGF2)
UniGene
GenAtlas
GDB
Nomenclature (search for IGF2)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND IGF2[TI] (PubMed)
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| IGF2 and Cancer (general)
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Issa JP, et al. Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci USA 1996; 93(21):11757-62 Related articles (PubMed)
Medline Search: IGF2 AND cancer (PubMed)
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 Resources by Disease Type
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| IGF2 Imprinting and Overexpression in Wilms' Tumour
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Ohlsson R, et al. Mosaic allelic insulin-like growth factor 2 expression patterns reveal a link between Wilms' tumorigenesis and epigenetic heterogeneity. Cancer Res 1999; 59(16):3889-92 Related articles (PubMed)
Dao D, et al. Multipoint analysis of human chromosome 11p15/mouse distal chromosome 7: inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting. Hum Mol Genet. 1999; 8(7):1337-52. Related articles (PubMed)
Drummond IA, et al. Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1. Science. 1992; 257(5070):674-8 Related articles (PubMed)
Medline Search: IGF2[ti] AND Wilms' tumor (PubMed)
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- Related Resources
- WT1 Gene
- IGF2R Imprinting Errors in Wilms' Tumour
Wilms' Tumour Genetics
Wilms' Tumour : Clinical and Epidemiological Information
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| IGF2 and Hepatoblastoma
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Rainier S, et al. Loss of imprinting in hepatoblastoma Cancer Res 1995; 55(9):1836-8 Related articles (PubMed)
Medline Search: IGF2 AND hepatoblastoma (PubMed)
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Hepatoblastoma Genetics
Hepatoblastoma : Clinical and Epidemiological Information
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| IGF2 Expression in Hepatocarcinoma
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Schwienbacher C, et al. Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas. Proc Natl Acad Sci USA 2000;97 5445-5449 Related articles (PubMed)
Medline Search: IGF2 AND hepatocarcinoma (PubMed)
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Hepatocelular Carcinoma Genetics
Hepatocelular Carcinoma : Clinical and Epidemiological Information
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| IGF2 and Colorectal Cancer
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Hodzic D, et al. Cloning of breakpoints in and downstream the IGF2 gene that are associated with overexpression of IGF2 transcripts in colorectal tumours. Oncogene. 1999; 18(33):4710-7 Related articles (PubMed)
Freier S, et al. Expression of the insulin-like growth factors and their receptors in adenocarcinoma of the colon. Gut 1999 May;44(5):704-8 Related articles (PubMed)
Kinouchi Y, et al. Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer. Cancer Lett. 1996; 107(1):105-8 Related articles (PubMed)
Medline Search: IGF2 AND colorectal cancer (PubMed)
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ColoRectal Cancers Genetics
ColoRectal Cancers : Clinical and Epidemiological Information
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| IGF2 and Breast Cancer
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Ellis MJ, et al. Insulin-like growth factors in human breast cancer. Breast Cancer Res Treat. 1998;52(1-3):175-84. [Review] Related articles (PubMed)
Wu HK, et al Relaxation of imprinting of human insulin-like growth factor II gene, IGF2, in sporadic breast carcinomas. Biochem Biophys Res Commun 1997; 235(1):123-9 Related articles (PubMed)
Medline Search: IGF2 AND breast cancer (PubMed)
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Breast Cancer Genetics
Breast Cancer : Clinical and Epidemiological Information
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| IGF2 Over-Expression in Adrenocortical Carcinoma
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Wilkin F, et al. Pediatric adrenocortical tumors: molecular events leading to insulin-like growth factor II gene overexpression. [Review] J Clin Endocrinol Metab 2000; 85(5):2048-56 Related articles (PubMed)
Boulle N, et al. Increased levels of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 are associated with malignancy in sporadic adrenocortical tumors. J Clin Endocrinol Metab 1998 May;83(5):1713-20 Related articles (PubMed)
Gicquel C, et al. Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumors. J Clin Endocrinol Metab 1997 Aug;82(8):2559-65 Related articles (PubMed)
Medline Search: IGF2 AND adrenocortical carcinoma (PubMed)
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Adrenocortical Carcinoma Genetics
Adrenocortical Carcinoma : Clinical and Epidemiological Information
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