Murthy SS, Testa JR Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma. [Review] J Cell Physiol 1999 Aug;180(2):150-7 Related articles (PubMed)
Lee WC, Testa JR Somatic genetic alterations in human malignant mesothelioma. [Review] Int J Oncol 1999 Jan;14(1):181-8 Related articles (PubMed)
 Mesothelioma Genetics
Mesothelioma : Clinical and Epidemiological Information
 Cytogenetics of Mesothelioma
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Balsara BR, et al. Comparative genomic hybridization and loss of heterozygosity analyses identify a common region of deletion at 15q11.1-15 in human malignant mesothelioma. Cancer Res 1999 Jan 15;59(2):450-4 Related articles (PubMed)
Bjorkqvist AM, et al. Recurrent DNA copy number changes in 1q, 4q, 6q, 9p, 13q, 14q and 22q detected by comparative genomic hybridization in malignant mesothelioma Br J Cancer 1997;75(4):523-7 Related articles (PubMed)
Bjorkqvist AM, et al. Comparison of DNA copy number changes in malignant mesothelioma, adenocarcinoma and large-cell anaplastic carcinoma of the lung. Br J Cancer 1998;77(2):260-9 Related articles (PubMed)
Medline Search: mesothelioma[TI] AND genetics (PubMed)
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Mesothelioma Genetics
Mesothelioma : Clinical and Epidemiological Information
| 14q Deletions in Mesothelioma (14q11-q12 and 14q23-q24)
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CGH studies indicate that loss of material from chromosome 14q is one of the most frequent aberrations in mesothelioma. A Finnish LOH study of primary tumour samples (Bjorkqvist, 1999) found 10/18 (56%) had 14q loss, with the most commonly involved regions
being 14q11.1-q12 and 14q23-q24. Similarly, in an American series (De Rienzo, 2000) 13/30 (43%) of tumours had LOH(14q) and 3 distinct regions were identified as 14q11.2-13.2, 14q22.3-24.3, and 14q32.12.
De Rienzo A, et al. Loss of heterozygosity analysis of 13q and 14q in human malignant mesothelioma. Genes Chromosomes Cancer 2000 Jul;28(3):337-41 Related articles (PubMed)
Bjorkqvist AM, et al. Deletions at 14q in malignant mesothelioma detected by microsatellite marker analysis. Br J Cancer 1999 Dec;81(7):1111-5 Related articles (PubMed)
Medline Search: mesothelioma AND 14q (PubMed)
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Chromosme 14
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