TCF3 - Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) - aka: E2A, ITF1

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TCF3; Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) (19p13.3)
TCF3 Menu Summary Information - TCF3 Gene Database Entries for TCF3 Other TCF3 Related Resources t(1;19)(q23;p13.3) in pre-B-cell ALL Feedback / suggest a new topic for TCF3
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Summary Information
TCF3; Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) Location: 19p13.3 Aliases: E2A, ITF1 Implicated in pre-b-cell acute lymphoblastic leukemia showing t(1;19)(q23;p13.3) Return to TCF3 Contents
Gene Database Entries for TCF3
OMIM GeneCard (Weizmann Institute) Atlas of Genetics and Cytogenetics in Oncology and Haematology Swiss-Prot Locus Link UniGene GenAtlas GDB Nomenclature (search for TCF3) Return to TCF3 Contents
Other Related Resources
Search Medline for related articles (PubMed) *Medline Search:* cancer AND gene AND (TCF3[TI] OR E2A[TI] OR ITF1[TI]) (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Return to TCF3 Contents
t(1;19)(q23;p13.3) in pre-B-cell ALL
t(1;19)(q23;p13.3) translocations fusing the PBX1 and E2A genes occur in approximately a quater of paediatric pre-B cell acute lymphoblastic laeukemias. LeBrun DP, et al. Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias. Oncogene. 1994; 9(6):1641-7. Related articles (PubMed) Lu Q, et al. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. Mol Cell Biol. 1994;14(6):3938-48 Related articles (PubMed) Kamps MP, et al. The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. Genes Dev 1991; 5(3):358-68 Related articles (PubMed) Izraeli S, et al. Expression of identical E2A/PBX1 fusion transcripts occurs in both pre-B and early pre-B immunological subtypes of childhood acute lymphoblastic leukemia Leukemia. 1993;7(12):2054-6. Related articles (PubMed) *Medline Search:* pre-B-cell acute lymphoblastic leukemia AND translocation (PubMed) Limit search to: [Last Year] Limit search to: [Last 2 Years] Limit search to: [Reviews] Related Resources Childhood Leukaemia Genetics Childhood Leukaemia : Clinical and Epidemiological Information Return to TCF3 Contents
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TCF3; Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)