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HFE; Hemochromatosis

Location: 6p21.3
Alias: HLA-H

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Nomenclature (search for HFE)

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Medline Search: cancer AND gene AND (HFE[TI] OR HLA-H[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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Hereditary hemochromatosis has an increased risk of hepatocellular carcinoma, HFE is a candidate gene for this disease. In a study of 61 cirrhotic patients who had surgery for hepatocellular carcinoma (Pirisi, 2000) there were significantly more HFE mutations compared to 149 contol subjects. Also, survival was significantly longer for patients with wild-type HFE than for those with HFE mutations.

Pirisi M, et al. Carriage of HFE Mutations and Outcome of Surgical Resection for Hepatocellular Carcinoma in Cirrhotic Patients Cancer 2000; 89:297-302    Related articles

Racchi O, et al. Mutations of the HFE gene and the risk of hepatocellular carcinoma. Blood Cells Mol Dis 1999 Oct-Dec;25(5-6):350-3    Related articles (PubMed)

Willis G, et al. Incidence of liver disease in people with HFE mutations. Gut 2000 Mar;46(3):401-4    Related articles (PubMed)

Willis G, et al. Haemochromatosis gene mutation in hepatocellular cancer. Lancet 1997 Aug 23;350(9077):565-6    Related articles (PubMed)

Medline Search: hepatocellular carcinoma AND (hfe OR hla-h) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
Hepatocelular Carcinoma Genetics
Hepatocelular Carcinoma : Clinical and Epidemiological Information

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