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  Chromosome 6

Genes Linked with Cancer

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 6; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
HSP90AB1 6p12 HSP84, HSPC2, HSPCB, D6S182, HSP90BSomatic
TFAP2B 6p12 AP-2B, AP2-B
VEGFA 6p12 VPF, VEGF, MVCD1
CCND3 6p21 Somatic
HMGA1 6p21 HMG-R, HMGIY, HMGA1ASomatic
SRSF3 6p21 SFRS3, SRp20Somatic
TFEB 6p21 TCFEB, BHLHE35, ALPHATFEBSomatic
FOXP4 6p21.1 hFKHLA
PPARD 6p21.2 FAAR, NUC1, NUCI, NR1C2, NUCII, PPARB-Bowel Cancer
-Lung Cancer
-Stomach Cancer
CDKN1A 6p21.2 P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1-Bowel Cancer
-Breast Cancer
-Eye Cancer
-Liver Cancer
-Skin Cancer
PIM1 6p21.2 PIMSomatic
HFE 6p21.3 HH, HFE1, HLA-H, MVCD7, TFQTL2
HLA-A 6p21.3 HLAA-Bladder Cancer
-Cervical Cancer
-Childhood Cancers
-Leukaemia
-Nasopharyngeal Cancer
DAXX 6p21.3 DAP6, EAP1, BING2Somatic
BAK1 6p21.3 BAK, CDN1, BCL2L7, BAK-LIKE
HLA-B 6p21.3 AS, HLAB, SPDA1
HLA-DQB1 6p21.3 IDDM1, CELIAC1, HLA-DQB
LTA 6p21.3 LT, TNFB, TNFSF1-Breast Cancer
-Cervical Cancer
-Non-Hodgkin Lymphoma
-Prostate Cancer
LTB 6p21.3 p33, TNFC, TNFSF3
NOTCH4 6p21.3 INT3, NOTCH3
TNF 6p21.3 DIF, TNFA, TNFSF2, TNF-alpha
HLA-DRB1 6p21.3 SS1, DRB1, DRw10, HLA-DRB, HLA-DR1B
POU5F1 6p21.31 OCT3, OCT4, OTF3, OTF4, OTF-3, Oct-3, Oct-4Somatic
HIST1H4I 6p21.33 H4M, H4/m, H4FMSomatic
FANCE 6p22-p21 FAE, FACEGermline-Fanconi Anaemia
TRIM27 6p22 RFP, RNF76Somatic
DEK 6p22.3 D6S231ESomatic
Translocation
-Acute Myeloid Leukaemia
TPMT 6p22.3
TFAP2A 6p24 AP-2, BOFS, AP2TF, TFAP2, AP-2alpha
IRF4 6p25-p23 MUM1, LSIRF, NF-EM5Somatic
Translocation
-Chronic Myelogenous Leukemia
-Lymphoma
-Multiple Myeloma
CASP8AP2 6q15 CED-4, FLASH, RIP25
FYN 6q21 SLK, SYN, p59-FYN
WISP3 6q21 PPD, CCN6, LIBC, PPAC
GOPC 6q21 CAL, FIG, PIST, GOPC1, dJ94G16.2Somatic
Fusion
-Lung Cancer, Non-Small Cell
FOXO3 6q21 FOXO2, AF6q21, FKHRL1, FOXO3A, FKHRL1P2Somatic
AIM1 6q21 ST4, CRYBG1
PRDM1 6q21 BLIMP1, PRDI-BF1Somatic
TPD52L1 6q22-q23 D53, hD53
MYB 6q22-q23 efg, Cmyb, c-myb, c-myb_CDSSomatic
ROS1 6q22 ROS, MCF3, c-ros-1Somatic
Fusion
-Brain and CNS Tumours
-Lung Cancer
-Lung Cancer, Non-Small Cell
GPRC6A 6q22.1 GPCR, bA86F4.3
RFX6 6q22.1 MTFS, RFXDC1, dJ955L16.1-Prostate Cancer
STL 6q22.33 RP11-510H23.1Somatic
TNFAIP3 6q23 A20, OTUD7C, TNFA1P2Somatic
ECT2L 6q24.1 LFDH, FBXO49, C6orf91, ARHGEF32, dJ509I19.2, dJ509I19.3, dJ509I19.5Somatic
ST8 6q25-q27 OVC, OVCS
VIP 6q25 PHM27
ESR1 6q25.1 ER, ESR, Era, ESRA, ESTRR, NR3A1
MAS1 6q25.3-q26 MAS
EZR 6q25.3 CVL, CVIL, VIL2Somatic
IGF2R 6q26 MPR1, MPRI, CD222, CIMPR, M6P-R
Imprinting errors
-Breast Cancer
-Liver Cancer
-Skin Cancer
-Wilms Tumour
THBS2 6q27 TSP2
FGFR1OP 6q27 FOPSomatic
MLLT4 6q27 AF6, RP3-431P23.3Somatic
Translocation
-Acute Myeloid Leukaemia
PDCD2 6q27 RP8, ZMYND7

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 6:

Abnormality Type Gene(s)
CD74-ROS1 fusion in NSCLCFusionROS1 (6q22)CD74 (5q32)
FIG-ROS1 Fusion in NSCLCFusionROS1 (6q22)GOPC (6q21)
SLC34A2-ROS1 Fusion in NSCLCFusionROS1 (6q22)SLC34A2 (4p15.2)
i(6p10) in RetinoblastomaIsochromosome
t(6;14)(p25,q32) in LymphomasTranslocationIRF4 (6p25-p23)IGH (14q32.33)
t(6;14)(p25;q32) in MyelomaTranslocationIRF4 (6p25-p23)IGH (14q32.33)
t(6;11)(q27;q23) in Acute Myeloid LeukemiaTranslocationMLLT4 (6q27)KMT2A (11q23)
t(6;9)(p23;q34) DEK-NUP214 in Acute Myeloid Leukaemia and Myelodysplastic SyndromeTranslocationDEK (6p22.3)NUP214 (9q34.1)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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