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  Chromosome 6

Genes Linked with Cancer (113)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 6; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
VEGFA 6p12 VPF, VEGF, MVCD1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Neuroblastoma
-Osteosarcoma
-Prostate Cancer
-Stomach Cancer
GNMT 6p12 -Liver Cancer
-Prostate Cancer
HSP90AB1 6p12 HSP84, HSPC2, HSPCB, D6S182, HSP90BSomatic-Acute Myeloid Leukaemia
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Stomach Cancer
TFAP2B 6p12 AP-2B, AP2-B-Acute Myeloid Leukaemia
-Breast Cancer
-Leukaemia
-Melanoma
IL17A 6p12 IL17, CTLA8, IL-17, IL-17A-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
GSTA1 6p12.1 GST2, GTH1, GSTA1-1-Breast Cancer
-Colorectal Cancer
-Ovarian Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
-Urinary System Cancers
PKHD1 6p12.2 FCYT, ARPKD, TIGM1-Kidney Cancer
TFEB 6p21 TCFEB, BHLHE35, ALPHATFEBSomatic-Childhood Cancers
-Kidney Cancer
CCND3 6p21 Somatic-Breast Cancer
-Mantle-Cell Lymphoma
-Multiple Myeloma
-Non-Hodgkin Lymphoma
-Stomach Cancer
-Uterine Sarcoma
RUNX2 6p21 CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1-Bone Cancer (primary)
-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
SRSF3 6p21 SFRS3, SRp20Somatic-Ovarian Cancer
-Soft Tissue Sarcoma
HMGA1 6p21 HMG-R, HMGIY, HMGA1ASomatic-Cervical Cancer
-Pituitary Tumors
-Soft Tissue Sarcoma
-Thyroid Cancer
FOXP4 6p21.1 hFKHLA-Prostate Cancer
SLC29A1 6p21.1 ENT1-Acute Lymphocytic Leukaemia (ALL)
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
PTK7 6p21.1-p12.2 CCK4, CCK-4-Colorectal Cancer
-Esophageal Cancer
-Stomach Cancer
POLH 6p21.1 XPV, XP-V, RAD30, RAD30A-Skin Cancer
CDKN1A 6p21.2 P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1Many cancer types including:
-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Eye Cancer
-Laryngeal Cancer
-Liver Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
-Parathyroid Cancer
-Prostate Cancer
-Skin Cancer
PPARD 6p21.2 FAAR, NUC1, NUCI, NR1C2, NUCII, PPARB-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
PIM1 6p21.2 PIMSomatic-Acute Myeloid Leukaemia
-Prostate Cancer
TAP2 6p21.3 APT2, PSF2, ABC18, ABCB3, PSF-2, RING11, D6S217E-Colorectal Cancer
HLA-DPB1 6p21.3 DPB1, HLA-DP, HLA-DPB, HLA-DP1B-Acute Lymphocytic Leukaemia (ALL)
-Cervical Cancer
-Chronic Myelogenous Leukemia
-Hodgkin Lymphoma
DDR1 6p21.3 CAK, DDR, NEP, HGK2, PTK3, RTK6, TRKE, CD167, EDDR1, MCK10, NTRK4, PTK3A-Breast Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
NOTCH4 6p21.3 INT3-Breast Cancer
-Salivary Gland Cancer
-Thyroid Cancer
MDC1 6p21.3 NFBD1-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
LTB 6p21.3 p33, TNFC, TNFSF3-Bladder Cancer
-Chronic Lymphocytic Leukemia
-Non-Hodgkin Lymphoma
TAP1 6p21.3 APT1, PSF1, ABC17, ABCB2, PSF-1, RING4, TAP1N, D6S114E, TAP1*0102N-Colorectal Cancer
-Melanoma
-Uterine Sarcoma
HLA-G 6p21.3 MHC-G-Bladder Cancer
-Cervical Cancer
-Stomach Cancer
-Thyroid Cancer
-Vaginal Cancer
HLA-C 6p21.3 HLC-C, D6S204, PSORS1, HLA-JY3-Cervical Cancer
-Melanoma
-Pancreatic Cancer
-Retinoblastoma
-Uterine Sarcoma
TNF 6p21.3 DIF, TNFA, TNFSF2, TNF-alpha-Bladder Cancer
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Skin Cancer
-Stomach Cancer
MICB 6p21.3 PERB11.2-Cervical Cancer
-Liver Cancer
HLA-DQA1 6p21.3 CD, GSE, DQ-A1, CELIAC1, HLA-DQA-Acute Myeloid Leukaemia
-Kaposi Sarcoma
-Ovarian Cancer
-Skin Cancer
HLA-DRA 6p21.3 MLRW, HLA-DRA1-Acute Myeloid Leukaemia
-Cervical Cancer
-Kaposi Sarcoma
-Melanoma
-Ovarian Cancer
-Skin Cancer
-Stomach Cancer
HLA-DRB1 6p21.3 SS1, DRB1, DRw10, HLA-DRB, HLA-DR1B-Acute Lymphocytic Leukaemia (ALL)
-Cervical Cancer
-Melanoma
-Prostate Cancer
-Stomach Cancer
-Testicular Cancer
-Uterine Sarcoma
-Vulvar Cancer
HLA-DQB1 6p21.3 IDDM1, CELIAC1, HLA-DQB-Acute Myeloid Leukaemia
-Childhood Cancers
-Kaposi Sarcoma
-Prostate Cancer
-Testicular Cancer
-Uterine Sarcoma
-Vulvar Cancer
SPDEF 6p21.3 PDEF, bA375E1.3-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
IER3 6p21.3 DIF2, IEX1, PRG1, DIF-2, GLY96, IEX-1, IEX-1L-Breast Cancer
-Osteosarcoma
-Pancreatic Cancer
-Prostate Cancer
HLA-E 6p21.3 MHC, QA1, EA1.2, EA2.1, HLA-6.2-Acute Myeloid Leukaemia
-Bladder Cancer
-Colorectal Cancer
-Liver Cancer
-Nasopharyngeal Cancer
-Skin Cancer
-Stomach Cancer
DAXX 6p21.3 DAP6, EAP1, BING2Somatic-Pancreatic Cancer
-Prostate Cancer
BAK1 6p21.3 BAK, CDN1, BCL2L7, BAK-LIKE
LTA 6p21.3 LT, TNFB, TNFSF1-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Non-Hodgkin Lymphoma
-Prostate Cancer
HLA-A 6p21.3 HLAA-Bladder Cancer
-Cervical Cancer
-Childhood Cancers
-Leukaemia
-Nasopharyngeal Cancer
-Stomach Cancer
HFE 6p21.3 HH, HFE1, HLA-H, MVCD7, TFQTL2-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
-Myelodysplastic Syndromes
-Skin Cancer
MAPK14 6p21.3-p21.2 RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Rectal Cancer
HLA-B 6p21.3 AS, HLAB, SPDA1-Childhood Cancers
-Melanoma
-Pancreatic Cancer
-Retinoblastoma
-Stomach Cancer
-Testicular Cancer
-Uterine Sarcoma
POU5F1 6p21.31 OCT3, OCT4, OTF3, OTF4, OTF-3, Oct-3, Oct-4Somatic-Breast Cancer
-Germ Cell Tumours
-Lung Cancer
MICA 6p21.33 MIC-A, PERB11.1-Liver Cancer
HIST1H4I 6p21.33 H4M, H4/m, H4FMSomatic
E2F3 6p22 E2F-3-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Neuroblastoma
-Ovarian Cancer
-Prostate Cancer
-Retinoblastoma
FANCE 6p22-p21 FAE, FACEGermline-Fanconi Anaemia
TRIM27 6p22 RFP, RNF76Somatic-Breast Cancer
-Cervical Cancer
-Childhood Cancers
-Endometrial Cancer
-Thyroid Cancer
SOX4 6p22.3 EVI16-Breast Cancer
-Lung Cancer
-Prostate Cancer
TPMT 6p22.3 -Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Skin Cancer
DEK 6p22.3 D6S231ESomatic
Translocation
-Acute Myeloid Leukaemia
-Bladder Cancer
-Retinoblastoma
GMNN 6p22.3 Gem-Breast Cancer
-Liver Cancer
CD83 6p23 BL11, HB15-Acute Lymphocytic Leukaemia (ALL)
-Cervical Cancer
-Chronic Myelogenous Leukemia
-Stomach Cancer
TFAP2A 6p24 AP-2, BOFS, AP2TF, TFAP2, AP-2alpha-Acute Myeloid Leukaemia
-Breast Cancer
-Leukaemia
-Melanoma
BMP6 6p24-p23 VGR, VGR1-Breast Cancer
-Lung Cancer
-Prostate Cancer
EEF1E1 6p24.3 P18, AIMP3
FOXC1 6p25 ARA, IGDA, IHG1, FKHL7, IRID1, RIEG3, FREAC3, FREAC-3-Breast Cancer
-Prostate Cancer
-Synovial Sarcoma
NEDD9 6p25-p24 CAS2, CASL, HEF1, CAS-L, CASS2-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
IRF4 6p25-p23 MUM1, LSIRF, SHEP8, NF-EM5Somatic
Translocation
-Childhood Cancers
-Chronic Lymphocytic Leukemia
-Chronic Myelogenous Leukemia
-Lymphoma
-Melanoma
-Multiple Myeloma
RREB1 6p25 HNT, FINB, LZ321, Zep-1, RREB-1-Bladder Cancer
-Melanoma
-Pancreatic Cancer
-Skin Cancer
RIPK1 6p25.2 RIP, RIP1-Eye Cancer
NQO2 6p25.2 QR2, DHQV, DIA6, NMOR2-Bladder Cancer
-Breast Cancer
-Esophageal Cancer
-Ovarian Cancer
-Stomach Cancer
PHIP 6q14 ndrp, BRWD2, WDR11, DCAF14-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
-Rectal Cancer
EEF1A1 6q14.1 CCS3, EF1A, PTI1, CCS-3, EE1A1, EEF-1, EEF1A, EF-Tu, LENG7, eEF1A-1, GRAF-1EF, HNGC:16303-Prostate Cancer
CASP8AP2 6q15 CED-4, FLASH, RIP25-Acute Lymphocytic Leukaemia (ALL)
-Childhood Cancers
-Colorectal Cancer
BACH2 6q15 BTBD25-Chronic Myelogenous Leukemia
-Multiple Myeloma
HACE1 6q16.3 Somatic
GWAS
-Neuroblastoma
-Wilms Tumour
TUBE1 6q21 TUBE, dJ142L7.2-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Small Cell Lung Cancer
-Ovarian Cancer
CCNC 6q21 CycC-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Prostate Cancer
ATG5 6q21 ASP, APG5, APG5L, hAPG5, APG5-LIKE-Breast Cancer
-Liver Cancer
-Lung Cancer
-Skin Cancer
GOPC 6q21 CAL, FIG, PIST, GOPC1, dJ94G16.2Somatic
Fusion
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
WISP3 6q21 PPD, CCN6, LIBC, PPAC-Breast Cancer
-Colorectal Cancer
FYN 6q21 SLK, SYN, p59-FYN-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Prostate Cancer
-Stomach Cancer
LIN28B 6q21 CSDD2-Brain Tumours, Childhood
-Liver Cancer
-Lung Cancer
-Neuroblastoma
-Ovarian Cancer
-Wilms Tumour
AIM1 6q21 ST4, CRYBG1-Bladder Cancer
-Melanoma
FOXO3 6q21 FOXO2, AF6q21, FKHRL1, FOXO3A, FKHRL1P2Somatic-Breast Cancer
HDAC2 6q21 HD2, RPD3, YAF1-Breast Cancer
CD24 6q21 CD24A-Breast Cancer
-Lung Cancer
-Prostate Cancer
-Thyroid Cancer
PRDM1 6q21 BLIMP1, PRDI-BF1Somatic-Childhood Cancers
-Multiple Myeloma
ROS1 6q22 ROS, MCF3, c-ros-1Somatic
Fusion
-Brain and CNS Tumours
-Lung Cancer
-Lung Cancer, Non-Small Cell
MYB 6q22-q23 efg, Cmyb, c-myb, c-myb_CDSSomatic-Adenoid Cystic Carcinoma
-Breast Cancer
-Cervical Cancer
-Childhood Cancers
-Melanoma
-Soft Tissue Sarcoma
FABP7 6q22-q23 MRG, BLBP, FABPB, B-FABP, LTR2-FABP7-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Kidney Cancer
-Melanoma
-Skin Cancer
TPD52L1 6q22-q23 D53, hD53-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Ovarian Cancer
GPRC6A 6q22.1 GPCR, bA86F4.3-Breast Cancer
-Prostate Cancer
RFX6 6q22.1 MTFS, MTCHRS, RFXDC1, dJ955L16.1-Prostate Cancer
PTPRK 6q22.2-q22.3 R-PTP-kappa-Brain and CNS Tumours
-Breast Cancer
-Melanoma
-Non-Hodgkin Lymphoma
-Prostate Cancer
GJA1 6q22.31 HSS, CMDR, CX43, GJAL, ODDD, AVSD3, HLHS1-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
MAP3K5 6q22.33 ASK1, MEKK5, MAPKKK5-Breast Cancer
-Melanoma
-Skin Cancer
RNF217-AS1 6q22.33 STLSomatic-Breast Cancer
-Chronic Myelogenous Leukemia
-Multiple Myeloma
-Ovarian Cancer
-Uterine Sarcoma
TNFAIP3 6q23 A20, OTUD7C, TNFA1P2Somatic-Breast Cancer
-Hodgkin Lymphoma
CTGF 6q23.1 CCN2, NOV2, HCS24, IGFBP8-Bone Cancer (primary)
-Breast Cancer
-Testicular Cancer
-Wilms Tumour
GRM1 6q24 MGLU1, GPRC1A, MGLUR1, SCAR13, PPP1R85-Breast Cancer
-Melanoma
-Skin Cancer
PLAGL1 6q24-q25 ZAC, LOT1, ZAC1-Breast Cancer
-Ovarian Cancer
-Pituitary Tumors
-Prostate Cancer
-Salivary Gland Cancer
AKAP12 6q24-q25 SSeCKS, AKAP250-Colorectal Cancer
-Leukaemia
-Lung Cancer
-Skin Cancer
PERP 6q24 THW, KCP1, PIGPC1, KRTCAP1, dJ496H19.1-Breast Cancer
-Esophageal Cancer
-Eye Cancer
-Melanoma
-Vulvar Cancer
ECT2L 6q24.1 LFDH, FBXO49, C6orf91, ARHGEF32, dJ509I19.2, dJ509I19.3, dJ509I19.5Somatic-Acute Myeloid Leukaemia
-Childhood Cancers
ULBP2 6q25 N2DL2, RAET1H-Acute Myeloid Leukaemia
-Melanoma
-Pancreatic Cancer
VIP 6q25 PHM27-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Neuroblastoma
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
ST8 6q25-q27 OVC, OVCS
LOH
-Ovarian Cancer
ESR1 6q25.1 ER, ESR, Era, ESRA, ESTRR, NR3A1-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Endometrial Cancer
-Prostate Cancer
LATS1 6q25.1 wts, WARTS-Breast Cancer
-Soft Tissue Sarcoma
PARK2 6q25.2-q27 PDJ, PRKN, AR-JP, LPRS2-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Melanoma
-Neuroblastoma
EZR 6q25.3 CVL, CVIL, VIL2, HEL-S-105Somatic-Lung Cancer
-Lung Cancer, Non-Small Cell
SOD2 6q25.3 IPOB, MNSOD, MVCD6-Breast Cancer
-Lung Cancer
-Prostate Cancer
MAS1 6q25.3-q26 MAS, MGRA-Leukaemia
-Melanoma
IGF2R 6q26 MPR1, MPRI, CD222, CIMPR, M6P-R
Imprinting errors
-Breast Cancer
-Liver Cancer
-Skin Cancer
-Wilms Tumour
MLLT4 6q27 AF6Somatic
Translocation
-Acute Myeloid Leukaemia
CCR6 6q27 BN-1, DCR2, DRY6, CCR-6, CD196, CKRL3, GPR29, CKR-L3, CMKBR6, GPRCY4, STRL22, CC-CKR-6, C-C CKR-6-Cutaneous T-cell lymphoma
-Liver Cancer
THBS2 6q27 TSP2-Liver Cancer
-Oral Cavity Cancer
-Ovarian Cancer
PDCD2 6q27 RP8, ZMYND7-Leukaemia
FGFR1OP 6q27 FOPSomatic-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Haematological Malignancies
-Leukaemia
-Myeloproliferative Disorders

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 6:

Abnormality Type Gene(s)
CD74-ROS1 fusion in NSCLCFusionROS1 (6q22)CD74 (5q32)
FIG-ROS1 Fusion in NSCLCFusionROS1 (6q22)GOPC (6q21)
SLC34A2-ROS1 Fusion in NSCLCFusionROS1 (6q22)SLC34A2 (4p15.2)
i(6p10) in RetinoblastomaIsochromosome
t(6;14)(p25,q32) in LymphomasTranslocationIRF4 (6p25-p23)IGH (14q32.33)
t(6;14)(p25;q32) in MyelomaTranslocationIRF4 (6p25-p23)IGH (14q32.33)
t(6;11)(q27;q23) in Acute Myeloid LeukemiaTranslocationMLLT4 (6q27)KMT2A (11q23)
t(6;9)(p23;q34) DEK-NUP214 in Acute Myeloid Leukaemia and Myelodysplastic SyndromeTranslocationDEK (6p22.3)NUP214 (9q34.1)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


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Cite this page: Cotterill SJ. Chromosome 6, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc06.htm Accessed: date

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