Chromosome 6

Genes Linked with Cancer (119)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 6; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
MIR1275 6 MIRN1275, mir-1275, hsa-mir-1275
GNMT 6p12 -Liver Cancer
-Prostate Cancer
IL17A 6p12.2 IL17, CTLA8, IL-17, CTLA-8, IL-17A-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
GSTA1 6p12.2 GST2, GTH1, GSTA1-1, GST-epsilon-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Ovarian Cancer
-Prostate Cancer
-Soft Tissue Sarcoma
-Urinary System Cancers
TFAP2B 6p12.3 PDA2, AP-2B, AP2-B-Acute Myeloid Leukaemia
-Breast Cancer
-Cervical Cancer
-Leukaemia
-Melanoma
-Neuroblastoma
-Uterine Sarcoma
PKHD1 6p12.3-p12.2 FPC, FCYT, ARPKD, TIGM1-Kidney Cancer
VEGFA 6p21.1 VPF, VEGF, MVCD1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Neuroblastoma
-Osteosarcoma
-Prostate Cancer
-Stomach Cancer
CCND3 6p21.1 Somatic-Breast Cancer
-Mantle-Cell Lymphoma
-Multiple Myeloma
-Non-Hodgkin Lymphoma
-Stomach Cancer
-Uterine Sarcoma
TFEB 6p21.1 TCFEB, BHLHE35, ALPHATFEBSomatic-Kidney Cancer
-Melanoma
-von Hippel-Lindau Disease
SLC29A1 6p21.1 ENT1-Acute Lymphocytic Leukaemia (ALL)
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
HSP90AB1 6p21.1 HSP84, HSPC2, HSPCB, D6S182, HSP90BSomatic-Acute Myeloid Leukaemia
-Gastrointestinal Stromal Tumors
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Stomach Cancer
FOXP4 6p21.1 hFKHLA-Bone Cancer (primary)
-Prostate Cancer
POLH 6p21.1 XPV, XP-V, RAD30, RAD30A-Skin Cancer
PTK7 6p21.1-p12.2 CCK4, CCK-4-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Stomach Cancer
RUNX2 6p21.1 CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1-Bone Cancer (primary)
-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
CDKN1A 6p21.2 P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1Many cancer types including:
-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Eye Cancer
-Laryngeal Cancer
-Liver Cancer
-Lung Cancer
-Melanoma
-Ovarian Cancer
-Parathyroid Cancer
-Prostate Cancer
-Skin Cancer
PIM1 6p21.2 PIMSomatic-Acute Myeloid Leukaemia
-Prostate Cancer
HSPA1B 6p21.3 HSP70-2, HSP70.2, HSP70-1B-Liver Cancer
-Lung Cancer
-Small Cell Lung Cancer
-Pancreatic Cancer
HLA-E 6p21.3 MHC, QA1, EA1.2, EA2.1, HLA-6.2-Acute Myeloid Leukaemia
-Bladder Cancer
-Colorectal Cancer
-Esophageal Cancer
-Liver Cancer
-Nasopharyngeal Cancer
-Skin Cancer
-Stomach Cancer
SPDEF 6p21.3 PDEF, bA375E1.3-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
IER3 6p21.3 DIF2, IEX1, PRG1, DIF-2, GLY96, IEX-1, IEX-1L-Breast Cancer
-Osteosarcoma
-Pancreatic Cancer
-Prostate Cancer
RXRB 6p21.3 NR2B2, DAUDI6, RCoR-1, H-2RIIBP-Lung Cancer
-Lung Cancer, Non-Small Cell
-Non-Hodgkin Lymphoma
-Oral Cavity Cancer
-Prostate Cancer
-Thyroid Cancer
BAK1 6p21.31 BAK, CDN1, BCL2L7, BAK-LIKE
PPARD 6p21.31 FAAR, NUC1, NUCI, NR1C2, NUCII, PPARB-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
MAPK14 6p21.31 RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Rectal Cancer
FANCE 6p21.31 FAE, FACEGermline-Fanconi Anaemia
SRSF3 6p21.31-p21.2 SFRS3, SRp20Somatic-Cervical Cancer
-Liver Cancer
-Ovarian Cancer
-Soft Tissue Sarcoma
HMGA1 6p21.31 HMG-R, HMGIY, HMGA1ASomatic-Breast Cancer
-Cervical Cancer
-Kidney Cancer
-Pituitary Tumors
-Soft Tissue Sarcoma
-Thyroid Cancer
NOTCH4 6p21.32 INT3-Breast Cancer
-Pancreatic Cancer
-Salivary Gland Cancer
-Thyroid Cancer
TAP1 6p21.32 APT1, PSF1, ABC17, ABCB2, PSF-1, RING4, TAP1N, D6S114E, TAP1*0102N-Colorectal Cancer
-Melanoma
-Uterine Sarcoma
HLA-DRA 6p21.32 HLA-DRA1-Acute Myeloid Leukaemia
-Cervical Cancer
-Kaposi Sarcoma
-Melanoma
-Ovarian Cancer
-Skin Cancer
-Stomach Cancer
HLA-DQA1 6p21.32 DQ-A1, CELIAC1, HLA-DQA-Acute Myeloid Leukaemia
-Kaposi Sarcoma
-Liver Cancer
-Ovarian Cancer
-Skin Cancer
HLA-DRB1 6p21.32 SS1, DRB1, HLA-DRB, HLA-DR1B-Acute Lymphocytic Leukaemia (ALL)
-Cervical Cancer
-Melanoma
-Nasopharyngeal Cancer
-Prostate Cancer
-Stomach Cancer
-Testicular Cancer
-Uterine Sarcoma
-Vulvar Cancer
HLA-DQB1 6p21.32 IDDM1, CELIAC1, HLA-DQB-Acute Myeloid Leukaemia
-Kaposi Sarcoma
-Prostate Cancer
-Testicular Cancer
-Uterine Sarcoma
-Vulvar Cancer
TAP2 6p21.32 APT2, PSF2, ABC18, ABCB3, PSF-2, RING11, D6S217E-Colorectal Cancer
HLA-DPB1 6p21.32 DPB1, HLA-DP, HLA-DPB, HLA-DP1B-Acute Lymphocytic Leukaemia (ALL)
-Cervical Cancer
-Chronic Myelogenous Leukemia
-Hodgkin Lymphoma
-Leukaemia
DAXX 6p21.32 DAP6, EAP1, BING2Somatic-Adrenocortical Cancer
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Pancreatic Cancer
-Prostate Cancer
-von Hippel-Lindau Disease
DDR1 6p21.33 CAK, DDR, NEP, HGK2, PTK3, RTK6, TRKE, CD167, EDDR1, MCK10, NTRK4, PTK3A-Breast Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
POU5F1 6p21.33 OCT3, OCT4, OTF3, OTF4, OTF-3, Oct-3, Oct-4Somatic-Breast Cancer
-Eye Cancer
-Germ Cell Tumours
-Lung Cancer
MICA 6p21.33 MIC-A, PERB11.1-Breast Cancer
-Liver Cancer
HLA-C 6p21.33 MHC, HLAC, HLC-C, D6S204, PSORS1, HLA-JY3-Cervical Cancer
-Melanoma
-Pancreatic Cancer
-Retinoblastoma
-Uterine Sarcoma
LTB 6p21.33 p33, TNFC, TNFSF3, TNLG1C-Bladder Cancer
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Lymphoma
-Multiple Myeloma
-Non-Hodgkin Lymphoma
-Thyroid Cancer
MDC1 6p21.33 NFBD1-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
TNF 6p21.33 DIF, TNFA, TNFSF2, TNLG1F, TNF-alpha-Bladder Cancer
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Skin Cancer
-Stomach Cancer
MICB 6p21.33 PERB11.2-Cervical Cancer
-Liver Cancer
-Pancreatic Cancer
LTA 6p21.33 LT, TNFB, TNFSF1, TNLG1E-Breast Cancer
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Non-Hodgkin Lymphoma
-Prostate Cancer
HLA-B 6p21.33 AS, HLAB, B-4901-Melanoma
-Pancreatic Cancer
-Retinoblastoma
-Stomach Cancer
-Testicular Cancer
-Uterine Sarcoma
HIST1H4I 6p22.1 H4M, H4/m, H4FMSomatic
TRIM27 6p22.1 RFP, RNF76Somatic-Breast Cancer
-Cervical Cancer
-Endometrial Cancer
-Ovarian Cancer
-Thyroid Cancer
HLA-G 6p22.1 MHC-G-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Stomach Cancer
-Thyroid Cancer
-Vaginal Cancer
HLA-A 6p22.1 HLAA-Bladder Cancer
-Cervical Cancer
-Leukaemia
-Nasopharyngeal Cancer
-Stomach Cancer
HFE 6p22.2 HH, HFE1, HLA-H, MVCD7, TFQTL2-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
-Myelodysplastic Syndromes
-Skin Cancer
DEK 6p22.3 D6S231ESomatic
Translocation
-Acute Myeloid Leukaemia
-Bladder Cancer
-Retinoblastoma
E2F3 6p22.3 E2F-3-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Neuroblastoma
-Ovarian Cancer
-Prostate Cancer
-Retinoblastoma
SOX4 6p22.3 EVI16-Breast Cancer
-Lung Cancer
-Prostate Cancer
-Thyroid Cancer
GMNN 6p22.3 Gem-Breast Cancer
-Liver Cancer
TPMT 6p22.3 TPMTD-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Skin Cancer
CD83 6p23 BL11, HB15-Acute Lymphocytic Leukaemia (ALL)
-Cervical Cancer
-Chronic Myelogenous Leukemia
-Stomach Cancer
NEDD9 6p24.2 CAS2, CASL, HEF1, CAS-L, CASS2-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Stomach Cancer
BMP6 6p24.3 VGR, VGR1-Breast Cancer
-Lung Cancer
-Prostate Cancer
RREB1 6p24.3 HNT, FINB, LZ321, Zep-1, RREB-1-Bladder Cancer
-Melanoma
-Pancreatic Cancer
-Skin Cancer
EEF1E1 6p24.3 P18, AIMP3-Bladder Cancer
TFAP2A 6p24.3 AP-2, BOFS, AP2TF, TFAP2, AP-2alpha-Acute Myeloid Leukaemia
-Breast Cancer
-Leukaemia
-Melanoma
FOXC1 6p25 ARA, IGDA, IHG1, FKHL7, IRID1, RIEG3, FREAC3, FREAC-3-Breast Cancer
-Prostate Cancer
-Synovial Sarcoma
NQO2 6p25.2 QR2, DHQV, DIA6, NMOR2-Bladder Cancer
-Breast Cancer
-Esophageal Cancer
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
RIPK1 6p25.2 RIP, RIP1-Eye Cancer
IRF4 6p25.3 MUM1, LSIRF, SHEP8, NF-EM5Somatic
Translocation
-Chronic Lymphocytic Leukemia
-Chronic Myelogenous Leukemia
-Hodgkin Lymphoma
-Lymphoma
-Melanoma
-Multiple Myeloma
EEF1A1 6q13 CCS3, EF1A, PTI1, CCS-3, EE1A1, EEF-1, EEF1A, EF-Tu, LENG7, eEF1A-1, GRAF-1EF, HNGC:16303-Prostate Cancer
PHIP 6q14.1 ndrp, BRWD2, WDR11, DCAF14-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
-Rectal Cancer
CASP8AP2 6q15 CED-4, FLASH, RIP25-Acute Lymphocytic Leukaemia (ALL)
-Colorectal Cancer
BACH2 6q15 BTBD25-Chronic Myelogenous Leukemia
-Multiple Myeloma
EPHA7 6q16.1 EHK3, EK11, EHK-3, HEK11-Colorectal Cancer
-Skin Cancer
HACE1 6q16.3 SPPRSSomatic
GWAS
-Neuroblastoma
-Wilms Tumour
LIN28B 6q16.3-q21 CSDD2-Brain Tumours, Childhood
-Liver Cancer
-Lung Cancer
-Neuroblastoma
-Ovarian Cancer
-Wilms Tumour
FOXO3 6q21 FOXO2, AF6q21, FKHRL1, FOXO3A, FKHRL1P2Somatic-Breast Cancer
-Lung Cancer
-Small Cell Lung Cancer
CCNC 6q21 CycC-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Prostate Cancer
-Uterine Sarcoma
AIM1 6q21 ST4, CRYBG1-Bladder Cancer
-Melanoma
FYN 6q21 SLK, SYN, p59-FYN-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Prostate Cancer
-Stomach Cancer
SEC63 6q21 ERdj2, SEC63L, DNAJC23, PRO2507-Colorectal Cancer
-Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
WISP3 6q21 PPD, CCN6, LIBC, PPAC, WISP-3-Breast Cancer
-Colorectal Cancer
PRDM1 6q21 BLIMP1, PRDI-BF1Somatic-Multiple Myeloma
ATG5 6q21 ASP, APG5, APG5L, hAPG5, APG5-LIKE-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Skin Cancer
-Thyroid Cancer
CD24 6q21 CD24A-Breast Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
-Skin Cancer
-Stomach Cancer
-Thyroid Cancer
HDAC2 6q21 HD2, RPD3, YAF1-Bladder Cancer
-Breast Cancer
TUBE1 6q21 TUBE, dJ142L7.2-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Small Cell Lung Cancer
-Ovarian Cancer
RFX6 6q22.1 MTFS, MTCHRS, RFXDC1, dJ955L16.1-Prostate Cancer
ROS1 6q22.1 ROS, MCF3, c-ros-1Somatic
Fusion
-Brain and CNS Tumours
-Lung Cancer
-Lung Cancer, Non-Small Cell
GOPC 6q22.1 CAL, FIG, PIST, GOPC1, dJ94G16.2Somatic
Fusion
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
GPRC6A 6q22.1 GPCR, bA86F4.3-Breast Cancer
-Prostate Cancer
RNF217-AS1 6q22.31 STLSomatic-Breast Cancer
-Chronic Myelogenous Leukemia
-Multiple Myeloma
-Ovarian Cancer
-Uterine Sarcoma
FABP7 6q22.31 MRG, BLBP, FABPB, B-FABP-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Kidney Cancer
-Melanoma
-Skin Cancer
GJA1 6q22.31 HSS, CMDR, CX43, EKVP, GJAL, ODDD, AVSD3, HLHS1-Breast Cancer
-Cervical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
TPD52L1 6q22.31 D53-Acute Lymphocytic Leukaemia (ALL)
-Breast Cancer
-Ovarian Cancer
MAP3K5 6q22.33 ASK1, MEKK5, MAPKKK5-Breast Cancer
-Melanoma
-Skin Cancer
PTPRK 6q22.33 R-PTP-kappa-Brain and CNS Tumours
-Breast Cancer
-Melanoma
-Non-Hodgkin Lymphoma
-Prostate Cancer
SGK1 6q23 SGK-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
CTGF 6q23.2 CCN2, NOV2, HCS24, IGFBP8-Bone Cancer (primary)
-Breast Cancer
-Testicular Cancer
-Thyroid Cancer
-Wilms Tumour
TNFAIP3 6q23.3 A20, AISBL, OTUD7C, TNFA1P2Somatic-MALT Lymphoma
-Breast Cancer
-Hodgkin Lymphoma
MYB 6q23.3 efg, Cmyb, c-myb, c-myb_CDSSomatic-Adenoid Cystic Carcinoma
-Breast Cancer
-Cervical Cancer
-Chronic Myelogenous Leukemia
-Leukaemia
-Melanoma
-Salivary Gland Cancer
-Skin Cancer
-Soft Tissue Sarcoma
-Uterine Sarcoma
GRM1 6q24 MGLU1, GPRC1A, MGLUR1, SCAR13, PPP1R85-Breast Cancer
-Melanoma
-Skin Cancer
PERP 6q24 THW, KCP1, PIGPC1, KRTCAP1, dJ496H19.1-Breast Cancer
-Esophageal Cancer
-Eye Cancer
-Melanoma
-Vulvar Cancer
ECT2L 6q24.1 LFDH, FBXO49, C6orf91, ARHGEF32, dJ509I19.2, dJ509I19.3, dJ509I19.5Somatic-Acute Myeloid Leukaemia
PLAGL1 6q24.2 ZAC, LOT1, ZAC1-Breast Cancer
-Cervical Cancer
-Ovarian Cancer
-Pituitary Tumors
-Prostate Cancer
-Salivary Gland Cancer
ULBP2 6q25 N2DL2, RAET1H, NKG2DL2, ALCAN-alpha-Acute Myeloid Leukaemia
-Melanoma
-Pancreatic Cancer
ST8 6q25-q27 OVC, OVCS
LOH
-Ovarian Cancer
LATS1 6q25.1 wts, WARTS-Breast Cancer
-Soft Tissue Sarcoma
ESR1 6q25.1-q25.2 ER, ESR, Era, ESRA, ESTRR, NR3A1-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Endometrial Cancer
-Prostate Cancer
-Uterine Sarcoma
AKAP12 6q25.1 SSeCKS, AKAP250-Colorectal Cancer
-Leukaemia
-Lung Cancer
-Skin Cancer
VIP 6q25.2 PHM27-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Neuroblastoma
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
SOD2 6q25.3 IPOB, IPO-B, MNSOD, MVCD6, Mn-SOD-Breast Cancer
-Lung Cancer
-Prostate Cancer
IGF2R 6q25.3 MPR1, MPRI, CD222, CIMPR, M6P-R, MPR300, CI-M6PR, MPR 300, M6P/IGF2R
Imprinting errors
-Breast Cancer
-Liver Cancer
-Skin Cancer
-Wilms Tumour
EZR 6q25.3 CVL, CVIL, VIL2, HEL-S-105Somatic-Esophageal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
MAS1 6q25.3 MAS, MGRA-Leukaemia
-Melanoma
PRKN 6q26 PDJ, AR-JP, LPRS2, PARK2-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Melanoma
-Neuroblastoma
CCR6 6q27 BN-1, DCR2, DRY6, CCR-6, CD196, CKRL3, GPR29, CKR-L3, CMKBR6, GPRCY4, STRL22, CC-CKR-6, C-C CKR-6-Cervical Cancer
-Colorectal Cancer
-Cutaneous T-cell lymphoma
-Liver Cancer
-Lung Cancer
PDCD2 6q27 RP8, ZMYND7-Colorectal Cancer
-Leukaemia
-Stomach Cancer
FGFR1OP 6q27 FOPSomatic-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Haematological Malignancies
-Leukaemia
-Myeloproliferative Disorders
AFDN 6q27 AF6, MLLT4, MLL-AF6, l-afadinSomatic
Translocation
-Acute Myeloid Leukaemia
THBS2 6q27 TSP2-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Oral Cavity Cancer
-Ovarian Cancer
-Stomach Cancer

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 6:

Abnormality Type Gene(s)
CD74-ROS1 fusion in NSCLCFusionROS1 (6q22.1)CD74 (5q33.1)
FIG-ROS1 Fusion in NSCLCFusionROS1 (6q22.1)GOPC (6q22.1)
SLC34A2-ROS1 Fusion in NSCLCFusionROS1 (6q22.1)SLC34A2 (4p15.2)
i(6p10) in RetinoblastomaIsochromosome
t(6;14)(p25,q32) in LymphomasTranslocationIRF4 (6p25.3)IGH (14q32.33)
t(6;14)(p25;q32) in MyelomaTranslocationIRF4 (6p25.3)IGH (14q32.33)
t(6;11)(q27;q23) in Acute Myeloid LeukemiaTranslocationAFDN (6q27)KMT2A (11q23.3)
t(6;9)(p23;q34) DEK-NUP214 in Acute Myeloid Leukaemia and Myelodysplastic SyndromeTranslocationDEK (6p22.3)NUP214 (9q34.13)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.

Further Resources (3 links)

Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.

Cite this page: Cotterill SJ. Chromosome 6, Cancer Genetics Web: http://www.cancer-genetics.org/clinkc06.htm Accessed:

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