 Summary Information
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Location: 9q34.1
Aliases: CAN, D9S46E
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| Gene Database Entries for NUP214
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OMIM
GeneCard (Weizmann Institute)
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Genbank
Swiss-Prot
Locus Link
UniGene
GDB
Nomenclature (search for NUP214)
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| Other Related Resources
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- Search Medline for related articles (PubMed)
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- Medline Search: cancer AND gene AND (NUP214[TI] OR CAN[TI] OR D9S46E[TI]) (PubMed)
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| t(6;9)(p23;q34) in Acute Myeloid Leukaemia
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The recurrent chromosomal translocation t(6;9)(p23;q34) involving the DEK and CAN (NUP214) genes occurs in a subset of patients with acute myeloid leukaemia. The DEK-CAN fusion protein (cloned by von Lindern et al,1992) consists of almost the whole of the
DEK protein fused to the C-terminal two-thirds of the CAN protein.
Fornerod M, et al. Interaction of cellular proteins with the leukemia specific fusion proteins DEK-CAN and SET-CAN and their normal counterpart, the nucleoporin CAN. Oncogene 1996 Oct 17;13(8):1801-8 Related articles (PubMed)
von Lindern M, et al. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. Mol Cell Biol 1992;12(4):1687-97 Related articles (PubMed)
Medline Search: leukemia AND translocation AND (CAN OR DEK OR t(6;9)) (PubMed)
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- Related Resources
 Acute Myeloid Leukaemia Genetics
Acute Myeloid Leukaemia : Clinical and Epidemiological Information
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| CAN-SET Translocation in Acute
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Fornerod M, et al. Interaction of cellular proteins with the leukemia specific fusion proteins DEK-CAN and SET-CAN and their normal counterpart, the nucleoporin CAN. Oncogene 1996 Oct 17;13(8):1801-8 Related articles (PubMed)
Medline Search: leukemia AND translocation AND (CAN OR SET) (PubMed)
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- Related Resources
Acute Myeloid Leukaemia Genetics
Acute Myeloid Leukaemia : Clinical and Epidemiological Information
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| Role of the NUP214 Gene in Cancer
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Boer J, et al. Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis. Mol Cell Biol 1998;18(3):1236-47 Related articles (PubMed)
Medline Search: cancer AND (CAN OR NUP214) (PubMed)
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[Home] This page created: 09/10/1999 Last revised: 29/04/2003 © Copyright 1999-
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