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    t(6;9)(p23;q34) in Acute Myeloid Leukaemia
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DEK; DEK gene

Location: 6p23
Alias: D6S231E

Forms a fusion gene with the CAN gene (9q34) in AML patients with t(6;9)(p23;q34) translocation.

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OMIM
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Locus Link
UniGene
GDB (search for DEK)
Nomenclature (search for DEK)

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Search Medline for related articles (PubMed)

Medline Search: cancer AND gene AND (DEK[TI] OR D6S231E[TI]) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

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The recurrent chromosomal translocation t(6;9)(p23;q34) involving the DEK and CAN (NUP214) genes occurs in a subset of patients with acute myeloid leukaemia. The DEK-CAN fusion protein (cloned by von Lindern et al,1992) consists of almost the whole of the DEK protein fused to the C-terminal two-thirds of the CAN protein.

Fornerod M, et al. Interaction of cellular proteins with the leukemia specific fusion proteins DEK-CAN and SET-CAN and their normal counterpart, the nucleoporin CAN. Oncogene 1996 Oct 17;13(8):1801-8    Related articles (PubMed)

von Lindern M, et al. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. Mol Cell Biol 1992;12(4):1687-97    Related articles (PubMed)

Medline Search: leukemia AND translocation AND (CAN OR DEK OR t(6;9)) (PubMed)   Limit search to: [Last Year]  Limit search to: [Last 2 Years]   Limit search to: [Reviews]

Related Resources
Acute Myeloid Leukaemia Genetics
Acute Myeloid Leukaemia : Clinical and Epidemiological Information

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