|Gene:||SIRT1; sirtuin 1|
|Aliases:||SIR2, SIR2L1, SIR2alpha|
|Summary:||This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]|
|Databases:||OMIM, HGNC, Ensembl, GeneCard, Gene|
|Protein:||NAD-dependent protein deacetylase sirtuin-1|
|Source:||NCBIAccessed: 31 August, 2019|
What does this gene/protein do?
|Pathways:||What pathways are this gene/protein implicaed in?|
Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.
Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Breast Cancer||SIRT1 and Breast Cancer||View Publications||48|
|Liver Cancer||SIRT1 and Liver Cancer||View Publications||46|
|Lung Cancer||SIRT1 and Lung Cancer||View Publications||36|
|Prostate Cancer||SIRT1 and Prostate Cancer||View Publications||25|
|Pancreatic Cancer||SIRT1 and Pancreatic Cancer||View Publications||27|
|Stomach Cancer||SIRT1 and Stomach Cancer||View Publications||17|
|-||SIRT1 and Triple Negative Breast Cancer||View Publications||3|
|Colorectal Cancer||SIRT1 and Colorectal Cancer||View Publications||40|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
OMIM, Johns Hopkin University
Referenced article focusing on the relationship between phenotype and genotype.
International Cancer Genome Consortium.
Summary of gene and mutations by cancer type from ICGC
Cancer Genome Anatomy Project, NCI
COSMIC, Sanger Institute
Somatic mutation information and related details
GEO Profiles, NCBI
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository.
Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.
Cite this page: Cotterill SJ. SIRT1, Cancer Genetics Web: http://www.cancer-genetics.org/SIRT1.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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[Home] Page last revised: 31 August, 2019 Cancer Genetics Web, Established 1999