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  Chromosome 9

Genes Linked with Cancer (76)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 9; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
BAG1 9p12 HAP, BAG-1, RAP46OverexpressionMany cancer types including:
-Breast Cancer
-Colorectal Cancer
-Endometrial Cancer
-Prostate Cancer
-Apoptosis
FANCG 9p13 FAG, XRCC9Germline-Fanconi Anaemia
CCL19 9p13 ELC, CKb11, MIP3B, MIP-3b, SCYA19-Chronic Lymphocytic Leukemia
-Colorectal Cancer
-Head and Neck Cancers
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Skin Cancer
GALT 9p13 -Breast Cancer
-Ovarian Cancer
PAX5 9p13 ALL3, BSAPGermline & Somatic
Translocation
-Acute Lymphocytic Leukemia (ALL), child
-Lymphoma
CCL21 9p13 ECL, SLC, CKb9, TCA4, 6Ckine, SCYA21-Breast Cancer
-Colorectal Cancer
MELK 9p13.2 HPK38-Brain Tumours, Childhood
-Breast Cancer
RECK 9p13.3 ST15-Cervical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Prostate Cancer
CDKN2B 9p21 P15, MTS2, TP15, CDK4I, INK4B, p15INK4b-Acute Lymphocytic Leukaemia (ALL)
-Bladder Cancer
-Brain Tumours, Childhood
-Childhood Cancers
MTAP 9p21 BDMF, MSAP, DMSFH, LGMBF, DMSMFH, c86fus, HEL-249-Acute Lymphocytic Leukaemia (ALL)
-Brain Tumours, Childhood
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
CDKN2A 9p21 ARF, MLM, P14, P16, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P14ARF, P19ARF, P16INK4, P16INK4A, P16-INK4AGermline & Somatic
Deletion
-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Ewing's Sarcoma
-Head and Neck Cancers
-Hodgkin Lymphoma
-Lung Cancer
-Melanoma
-Familial Melanoma
-Mesothelioma
-Neurofibromatosis
-Osteosarcoma
-Pancreatic Cancer
-Familial Pancreatic Cancer
-Rhabdomyosarcoma
-Wilms Tumour
RPS6 9p21 S6-Astrocytoma, Childhood
-Liver Cancer
-Oral Cavity Cancer
-Pancreatic Cancer
CDKN2B-AS1 9p21.3 ANRIL, p15AS, PCAT12, CDKN2BAS, CDKN2B-AS, NCRNA00089Germline
MLLT3 9p22 AF9, YEATS3Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Childhood Cancers
-Leukaemia
IFNA17 9p22 IFNA, INFA, LEIF2C1, IFN-alphaI-Acute Lymphocytic Leukaemia (ALL)
-Chronic Myelogenous Leukemia
-Kidney Cancer
-Liver Cancer
-Multiple Myeloma
IFNA7 9p22 IFNA-J, IFN-alphaJ-Acute Lymphocytic Leukaemia (ALL)
-Chronic Myelogenous Leukemia
-Kidney Cancer
-Liver Cancer
-Multiple Myeloma
IFNA2 9p22 IFNA, INFA2, IFNA2B, IFN-alphaA-Acute Lymphocytic Leukaemia (ALL)
-Chronic Myelogenous Leukemia
-Kidney Cancer
-Liver Cancer
-Multiple Myeloma
PSIP1 9p22.3 p52, p75, PAIP, DFS70, LEDGF, PSIP2Somatic-Acute Myeloid Leukaemia
-Bladder Cancer
-Leukaemia
SMARCA2 9p22.3 BRM, SNF2, SWI2, hBRM, NCBRS, Sth1p, BAF190, SNF2L2, SNF2LA, hSNF2a-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
PTPRD 9p23-p24.3 HPTP, PTPD, HPTPD, HPTPDELTA, RPTPDELTA-Lung Cancer
-Melanoma
TYRP1 9p23 TRP, CAS2, CATB, GP75, OCA3, TRP1, TYRP, b-PROTEIN-Eye Cancer
-Melanoma
-Skin Cancer
CD274 9p24 B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1Somatic-Melanoma
-Stomach Cancer
JAK2 9p24 JTK10, THCYT3Somatic-Leukaemia
-Myeloproliferative Disorders
-Skin Cancer
-Stomach Cancer
MLANA 9p24.1 MART1, MART-1-Kaposi Sarcoma
-Melanoma
KDM4C 9p24.1 GASC1, JHDM3C, JMJD2C, TDRD14C, bA146B14.1-Acute Myeloid Leukaemia
-Breast Cancer
-Esophageal Cancer
-Prostate Cancer
NFIB 9p24.1 CTF, NF1-B, NFI-B, NFIB2, NFIB3, NF-I/B, NFI-RED, HMGIC/NFIBSomatic-Adenoid Cystic Carcinoma
-Breast Cancer
-Head and Neck Cancers
-Small Cell Lung Cancer
-Salivary Gland Cancer
PDCD1LG2 9p24.2 B7DC, Btdc, PDL2, CD273, PD-L2, PDCD1L2, bA574F11.2Somatic-Acute Myeloid Leukaemia
-Chronic Myelogenous Leukemia
-Hodgkin Lymphoma
-Stomach Cancer
GNAQ 9q21 GAQ, SWS, CMC1, G-ALPHA-qSomatic-Eye Cancer
-Melanoma
ALDH1A1 9q21.13 ALDC, ALDH1, HEL-9, HEL12, PUMB1, ALDH11, RALDH1, ALDH-E1, HEL-S-53e-Breast Cancer
-Lung Cancer
ANXA1 9q21.13 ANX1, LPC1-Bladder Cancer
-Breast Cancer
-Stomach Cancer
PCA3 9q21.2 DD3, PCAT3, NCRNA00019-Cancer Screening
-Prostate Cancer
GAS1 9q21.3-q22 -Brain Stem Glioma, Childhood
-Prostate Cancer
-Uterine Sarcoma
RMI1 9q21.32 BLAP75, FAAP75, C9orf76-Acute Myeloid Leukaemia
-Bone Cancer (primary)
-Osteosarcoma
-Prostate Cancer
-Skin Cancer
TLE1 9q21.32 ESG, ESG1, GRG1-Acute Myeloid Leukaemia
-Breast Cancer
-Cervical Cancer
-Soft Tissue Sarcoma
-Synovial Sarcoma
DAPK1 9q21.33 DAPK-Bladder Cancer
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Skin Cancer
-Soft Tissue Sarcoma
-Stomach Cancer
-Thyroid Cancer
-Urinary System Cancers
CTSL 9q21.33 MEP, CATL, CTSL1-Breast Cancer
-Esophageal Cancer
-Melanoma
-Osteosarcoma
-Thyroid Cancer
NR4A3 9q22 CHN, TEC, CSMF, NOR1, MINORSomatic
Translocation
-Bone Cancer (primary)
-Cervical Cancer
-Chondrosarcoma
-Soft Tissue Sarcoma
FOXE1 9q22 TTF2, FOXE2, HFKH4, HFKL5, TITF2, TTF-2, FKHL15-Pancreatic Cancer
-Skin Cancer
TGFBR1 9q22 AAT5, ALK5, ESS1, LDS1, MSSE, SKR4, ALK-5, LDS1A, LDS2A, TGFR-1, ACVRLK4, tbetaR-I-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Pancreatic Cancer
-Skin Cancer
CKS2 9q22 CKSHS2-Bladder Cancer
-Cervical Cancer
-Colorectal Cancer
-Esophageal Cancer
-Liver Cancer
-Prostate Cancer
SYK 9q22 p72-SykSomatic-Breast Cancer
-Chronic Lymphocytic Leukemia
ROR2 9q22 BDB, BDB1, NTRKR2-Chronic Lymphocytic Leukemia
-Lung Cancer
-Stomach Cancer
NTRK2 9q22.1 TRKB, trk-B, GP145-TrkB-Cervical Cancer
-Neuroblastoma
-Oral Cavity Cancer
-Wilms Tumour
FANCC 9q22.3 FA3, FAC, FACCGermline-Fanconi Anaemia
XPA 9q22.3 XP1, XPACGermline-Childhood Cancers
-Lung Cancer
-Skin Cancer
PTCH1 9q22.3 PTC, BCNS, HPE7, PTC1, PTCH, NBCCS, PTCH11Germline & Somatic-Medulloblastoma
-Cervical Cancer
-Childhood Cancers
-Basal Cell Carcinoma (BCC) - Skin
-Stomach Cancer
OMD 9q22.31 OSAD, SLRR2CSomatic-Childhood Cancers
KLF4 9q31 EZF, GKLF-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Stomach Cancer
-Uterine Sarcoma
ABCA1 9q31.1 TGD, ABC1, CERP, ABC-1, HDLDT1-Breast Cancer
-Liver Cancer
-Prostate Cancer
RAD23B 9q31.2 P58, HR23B, HHR23B-Bladder Cancer
-Breast Cancer
-Liver Cancer
-Lung Cancer
PTGS1 9q32-q33.3 COX1, COX3, PHS1, PCOX1, PES-1, PGHS1, PTGHS, PGG/HS, PGHS-1-Colorectal Cancer
TAL2 9q32 Somatic-Ovarian Cancer
DEC1 9q32 CTS9-Breast Cancer
-Esophageal Cancer
-Lung Cancer
-Pancreatic Cancer
TNFSF15 9q32 TL1, TL1A, VEGI, VEGI192A-Bladder Cancer
-Breast Cancer
-Kidney Cancer
BRINP1 9q32-q33 DBC1, FAM5A, DBCCR1
NR5A1 9q33 ELP, SF1, FTZ1, POF7, SF-1, AD4BP, FTZF1, SPGF8, SRXY3-Adrenocortical Cancer
-Ovarian Cancer
TRAF1 9q33-q34 EBI6, MGC:10353-Breast Cancer
DAB2IP 9q33.1-q33.3 AIP1, AIP-1, AF9Q34, DIP1/2-Bladder Cancer
-Lung Cancer
-Prostate Cancer
TLR4 9q33.1 TOLL, CD284, TLR-4, ARMD10-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
-Stomach Cancer
PAPPA 9q33.2 PAPA, DIPLA1, PAPP-A, PAPPA1, ASBABP2, IGFBP-4ase-Acute Myeloid Leukaemia
-Cervical Cancer
-Chronic Lymphocytic Leukemia
-Haematological Malignancies
-Ovarian Cancer
CNTRL 9q33.2 FAN, CEP1, CEP110, bA165P4.1Somatic-Acute Myeloid Leukaemia
-Brain and CNS Tumours
-Myeloproliferative Disorders
TSC1 9q34 LAM, TSCGermline-Childhood Cancers
-Kidney Cancer
-Lung Cancer
BRD3 9q34 ORFX, RING3LSomatic-Acute Myeloid Leukaemia
-Childhood Cancers
TRAF2 9q34 TRAP, TRAP3, MGC:45012-Breast Cancer
LCN2 9q34 24p3, MSFI, NGAL-Breast Cancer
-Esophageal Cancer
-Liver Cancer
-Pancreatic Cancer
FNBP1 9q34 FBP17Somatic-Esophageal Cancer
SET 9q34 2PP2A, IGAAD, TAF-I, I2PP2A, IPP2A2, PHAPII, TAF-IBETASomatic
Translocation
-Acute Myeloid Leukaemia
-Wilms Tumour
CDK9 9q34.1 TAK, C-2k, CTK1, CDC2L4, PITALRE-Breast Cancer
-Cervical Cancer
NUP214 9q34.1 CAN, CAIN, N214, p250, D9S46ESomatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
ABL1 9q34.1 ABL, JTK7, p150, c-ABL, v-abl, c-ABL1, bcr/ablSomatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Chronic Myelogenous Leukemia
FPGS 9q34.1 -Acute Lymphocytic Leukaemia (ALL)
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
TTF1 9q34.13 TTF-1, TTF-I-Lung Cancer
-Lung Cancer, Non-Small Cell
-Small Cell Lung Cancer
-Thyroid Cancer
RALGDS 9q34.3 RGF, RGDS, RalGEFSomatic-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
NOTCH1 9q34.3 hN1, AOS5, TAN1, AOVD1Somatic
Translocation
-Acute Lymphocytic Leukaemia (ALL)
-Acute Lymphocytic Leukemia (ALL), child
-Breast Cancer
-Childhood Cancers
-Chronic Lymphocytic Leukemia
-Esophageal Cancer
-Head and Neck Cancers
-Thyroid Cancer
RAPGEF1 9q34.3 C3G, GRF2
RXRA 9q34.3 NR2B1-Childhood Cancers
-Liver Cancer
-Prostate Cancer
-Retinoblastoma

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 9:

Abnormality Type Gene(s)
t(9;22)(p24;q11.2) BCR-JAK2 fusion JAK2 (9p24)BCR (22q11.23)
del(9p) in Lung CancerDeletion
del(9p) in NeuroblastomaDeletion
del(9q) in Bladder CancerDeletion
BCR-ABL Translocation in Acute Lymphoblastic LeukaemiaTranslocationABL1 (9q34.1)BCR (22q11.23)
BCR-ABL Translocation in Chronic Myeloid LeukaemiaTranslocationABL1 (9q34.1)BCR (22q11.23)
t(9;22)(q22;q12) in Extraskeletal Myxoid ChondrosarcomaTranslocationNR4A3 (9q22)EWSR1 (22q12.2)
t(8;9)(p22;p24) PCM1-JAK2 fusion in Hematologic MalignanciesTranslocationJAK2 (9p24)PCM1 (8p22-p21.3)
t(9;12)(p24;p13) ETV6-JAK2 fusion in lymphoid and myeloid leukemiaTranslocationJAK2 (9p24)ETV6 (12p13)
t(9;11) in Acute Myeloid LeukaemiaTranslocationMLLT3 (9p22)KMT2A (11q23)
t(7;9)(q34;q34) in T-Cell Acute Lymphoblastic LeukaemiaTranslocationNOTCH1 (9q34.3)TRB (7q34)
t(9;14)(p13;q32) in LymphomaTranslocationPAX5 (9p13)
t(9;9)(q34;q34) SET-NUP214 rearrangements in Acute Lyphoblastic LeukaemiaTranslocationSET (9q34)NUP214 (9q34.1)
t(9;17)(q22;q11) in Extraskeletal Myxoid ChondrosarcomaTranslocationNR4A3 (9q22)TAF15 (17q11.1-q11.2)
t(6;9)(p23;q34) DEK-NUP214 in Acute Myeloid Leukaemia and Myelodysplastic SyndromeTranslocationNUP214 (9q34.1)DEK (6p22.3)

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.


Further Resources (2 links)

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Cite this page: Cotterill SJ. Chromosome 9, Cancer Genetics Web: http://www.cancerindex.org/geneweb/clinkc09.htm Accessed: date

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